Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes

Aims/hypothesis We aimed to elucidate the impact of fat cell size and inflammatory status of adipose tissue on the development of type 2 diabetes in non-obese individuals. Methods We characterised subcutaneous abdominal adipose tissue by examining stromal cell populations by 13 colour flow cytometry...

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Veröffentlicht in:	Diabetologia 2016-03, Vol.59 (3), p.560-570
Hauptverfasser:	Acosta, Juan R., Douagi, Iyadh, Andersson, Daniel P., Bäckdahl, Jesper, Rydén, Mikael, Arner, Peter, Laurencikiene, Jurga
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - metabolism Adipocytes - pathology Adipose Tissue, White - metabolism Adipose Tissue, White - pathology Adult Aged Body fat Case-Control Studies Diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Female Flow cytometry Genotype & phenotype Glucose Human Physiology Humans Inflammation Insulin - metabolism Insulin resistance Insulin Resistance - physiology Internal Medicine Lipids Lipolysis - physiology Macrophages - metabolism Macrophages - physiology Male Medicine Medicine & Public Health Metabolic Diseases Metabolism Middle Aged Obesity Obesity - metabolism Obesity - pathology Proteins Subcutaneous Fat - metabolism Subcutaneous Fat - pathology Tumor Necrosis Factor-alpha - metabolism
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