Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome

Acetaminophen overdose is the leading cause of acute liver failure. One dose of 10–15 g causes severe liver damage in humans, whereas repeated exposure to acetaminophen in humans and animal models results in autoprotection. Insight of this process is limited to select proteins implicated in acetamin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	SCIENTIFIC REPORTS 2015-11, Vol.5 (1), p.16423-16423, Article 16423
Hauptverfasser:	Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., Starkey Lewis, P., Vasieva, O., Prats, N., Brillant, N., Auli, M., Bayliss, M., Webb, S., Rees, J. A., Kitteringham, N. R., Goldring, C. E., Park, B. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/1438 631/337/475 Acetaminophen Acetaminophen - pharmacology Adaptation, Physiological - drug effects Analgesics Animal models Animals Cytochrome P-450 CYP2E1 - metabolism Drug overdose Humanities and Social Sciences Liver Liver - drug effects Liver - enzymology Liver - metabolism Liver diseases Male Mass spectrometry Mass spectroscopy Mice, Inbred C57BL multidisciplinary Overdose Proteome - metabolism Proteomes Proteomics Rats Rodents Science Signal Transduction - drug effects Spatial distribution Toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!