Contact system revisited: an interface between inflammation, coagulation, and innate immunity

Summary The contact system is a plasma protease cascade initiated by factor XII (FXII) that activates the proinflammatory kallikrein‐kinin system and the procoagulant intrinsic coagulation pathway. Anionic surfaces induce FXII zymogen activation to form proteolytically active FXIIa. Bacterial surfac...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2016-03, Vol.14 (3), p.427-437
Hauptverfasser:	Long, A. T., Kenne, E., Jung, R., Fuchs, T. A., Renné, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	angioedema Angioedemas, Hereditary - blood Angioedemas, Hereditary - immunology Animals anticoagulation Blood Coagulation factor XII Factor XII - metabolism Hepatocytes - immunology Hepatocytes - metabolism Humans Hypersensitivity - blood Hypersensitivity - immunology Immunity, Innate inflammation Inflammation - blood Inflammation - immunology Inflammation Mediators - blood Inflammation Mediators - immunology polyphosphates Polyphosphates - blood Signal Transduction thrombosis Thrombosis - blood Thrombosis - immunology
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