Post mTBI fatigue is associated with abnormal brain functional connectivity
This study set out to investigate the behavioral correlates of changes in resting-state functional connectivity before and after performing a 20 minute continuous psychomotor vigilance task (PVT) for patients with chronic post-concussion syndrome. Ten patients in chronic phase after mild traumatic b...
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| Veröffentlicht in: | Scientific reports 2016-02, Vol.6 (1), p.21183-21183, Article 21183 |
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| creator | Nordin, Love Engström Möller, Marika Christina Julin, Per Bartfai, Aniko Hashim, Farouk Li, Tie-Qiang |
| description | This study set out to investigate the behavioral correlates of changes in resting-state functional connectivity before and after performing a 20 minute continuous psychomotor vigilance task (PVT) for patients with chronic post-concussion syndrome. Ten patients in chronic phase after mild traumatic brain injury (mTBI) with persisting symptoms of fatigue and ten matched healthy controls participated in the study. We assessed the participants’ fatigue levels and conducted resting-state fMRI before and after a sustained PVT. We evaluated the changes in brain functional connectivity indices in relation to the subject’s fatigue behavior using a quantitative data-driven analysis approach. We found that the PVT invoked significant mental fatigue and specific functional connectivity changes in mTBI patients. Furthermore, we found a significant linear correlation between self-reported fatigue and functional connectivity in the thalamus and middle frontal cortex. Our findings indicate that resting-state fMRI measurements may be a useful indicator of performance potential and a marker of fatigue level in the neural attentional system. |
| doi_str_mv | 10.1038/srep21183 |
| format | Article |
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Ten patients in chronic phase after mild traumatic brain injury (mTBI) with persisting symptoms of fatigue and ten matched healthy controls participated in the study. We assessed the participants’ fatigue levels and conducted resting-state fMRI before and after a sustained PVT. We evaluated the changes in brain functional connectivity indices in relation to the subject’s fatigue behavior using a quantitative data-driven analysis approach. We found that the PVT invoked significant mental fatigue and specific functional connectivity changes in mTBI patients. Furthermore, we found a significant linear correlation between self-reported fatigue and functional connectivity in the thalamus and middle frontal cortex. Our findings indicate that resting-state fMRI measurements may be a useful indicator of performance potential and a marker of fatigue level in the neural attentional system.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep21183</identifier><identifier>PMID: 26878885</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 692/617/375/1345 ; 692/700/1421/1628 ; Adult ; Analysis of Variance ; Attention ; Brain Mapping ; Case-Control Studies ; Chronic Traumatic Encephalopathy - complications ; Chronic Traumatic Encephalopathy - diagnosis ; Chronic Traumatic Encephalopathy - physiopathology ; Concussion ; Cortex (frontal) ; Data processing ; Fatigue ; Fatigue - diagnosis ; Fatigue - etiology ; Female ; Functional magnetic resonance imaging ; Humanities and Social Sciences ; Humans ; Magnetic Resonance Imaging ; Male ; Medicin och hälsovetenskap ; Middle Aged ; multidisciplinary ; Neural networks ; Psychomotor Performance ; Science ; Science (multidisciplinary) ; Thalamus ; Traumatic brain injury ; Vigilance ; Young Adult</subject><ispartof>Scientific reports, 2016-02, Vol.6 (1), p.21183-21183, Article 21183</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Feb 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-67bcc22fdd07179b54db2d68bcb80ca236f6597b2c14f567488366835d32b0333</citedby><cites>FETCH-LOGICAL-c563t-67bcc22fdd07179b54db2d68bcb80ca236f6597b2c14f567488366835d32b0333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754765/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754765/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26878885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280240$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:132974530$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nordin, Love Engström</creatorcontrib><creatorcontrib>Möller, Marika Christina</creatorcontrib><creatorcontrib>Julin, Per</creatorcontrib><creatorcontrib>Bartfai, Aniko</creatorcontrib><creatorcontrib>Hashim, Farouk</creatorcontrib><creatorcontrib>Li, Tie-Qiang</creatorcontrib><title>Post mTBI fatigue is associated with abnormal brain functional connectivity</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>This study set out to investigate the behavioral correlates of changes in resting-state functional connectivity before and after performing a 20 minute continuous psychomotor vigilance task (PVT) for patients with chronic post-concussion syndrome. Ten patients in chronic phase after mild traumatic brain injury (mTBI) with persisting symptoms of fatigue and ten matched healthy controls participated in the study. We assessed the participants’ fatigue levels and conducted resting-state fMRI before and after a sustained PVT. We evaluated the changes in brain functional connectivity indices in relation to the subject’s fatigue behavior using a quantitative data-driven analysis approach. We found that the PVT invoked significant mental fatigue and specific functional connectivity changes in mTBI patients. Furthermore, we found a significant linear correlation between self-reported fatigue and functional connectivity in the thalamus and middle frontal cortex. Our findings indicate that resting-state fMRI measurements may be a useful indicator of performance potential and a marker of fatigue level in the neural attentional system.</description><subject>59/57</subject><subject>692/617/375/1345</subject><subject>692/700/1421/1628</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Attention</subject><subject>Brain Mapping</subject><subject>Case-Control Studies</subject><subject>Chronic Traumatic Encephalopathy - complications</subject><subject>Chronic Traumatic Encephalopathy - diagnosis</subject><subject>Chronic Traumatic Encephalopathy - physiopathology</subject><subject>Concussion</subject><subject>Cortex (frontal)</subject><subject>Data processing</subject><subject>Fatigue</subject><subject>Fatigue - diagnosis</subject><subject>Fatigue - etiology</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Neural networks</subject><subject>Psychomotor Performance</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Thalamus</subject><subject>Traumatic brain injury</subject><subject>Vigilance</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>D8T</sourceid><recordid>eNp1kk1vFDEMhkcIRKu2B_4AGokLIAby_XFBKgVKRSU4FK5RkslsU2aSJcm06r8nq90uW1BziWM_r205bppnELyFAIt3ObklglDgR80-AoR2CCP0eMfea45yvgL1UCQJlE-bPcQEF0LQ_ebr95hLO118OGsHXfxidq3Prc45Wq-L69sbXy5bbUJMkx5bk7QP7TAHW3wM1WFjCK4-rn25PWyeDHrM7mhzHzQ_Pn-6OPnSnX87PTs5Pu8sZbh0jBtrERr6HnDIpaGkN6hnwlgjgNUIs4FRyQ2ykAyUcSIEZkxg2mNkAMb4oOnWefONW85GLZOfdLpVUXu1cf2qllMUcIRI5eWD_DLF_q_oTggxkpxQDKr2zYPaj_7nsYppoeZZIQEQWeHv13hlJ9dbF0rS4_2K9yLBX6pFvFaEU8IZrQlebhKk-Ht2uajJZ-vGUQcX56xghSQUUIqKvvgHvYpzqp9SKSGFZADS1bBerSmbYq67MmybgUCtFkhtF6iyz3e735J361KB15tp1FBYuLRT8r9sfwAxbtC-</recordid><startdate>20160216</startdate><enddate>20160216</enddate><creator>Nordin, Love Engström</creator><creator>Möller, Marika Christina</creator><creator>Julin, Per</creator><creator>Bartfai, Aniko</creator><creator>Hashim, Farouk</creator><creator>Li, Tie-Qiang</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>ACNBI</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DF2</scope><scope>ZZAVC</scope></search><sort><creationdate>20160216</creationdate><title>Post mTBI fatigue is associated with abnormal brain functional connectivity</title><author>Nordin, Love Engström ; Möller, Marika Christina ; Julin, Per ; Bartfai, Aniko ; Hashim, Farouk ; Li, Tie-Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-67bcc22fdd07179b54db2d68bcb80ca236f6597b2c14f567488366835d32b0333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>59/57</topic><topic>692/617/375/1345</topic><topic>692/700/1421/1628</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Attention</topic><topic>Brain Mapping</topic><topic>Case-Control Studies</topic><topic>Chronic Traumatic Encephalopathy - complications</topic><topic>Chronic Traumatic Encephalopathy - diagnosis</topic><topic>Chronic Traumatic Encephalopathy - physiopathology</topic><topic>Concussion</topic><topic>Cortex (frontal)</topic><topic>Data processing</topic><topic>Fatigue</topic><topic>Fatigue - diagnosis</topic><topic>Fatigue - etiology</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Neural networks</topic><topic>Psychomotor Performance</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Thalamus</topic><topic>Traumatic brain injury</topic><topic>Vigilance</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nordin, Love Engström</creatorcontrib><creatorcontrib>Möller, Marika Christina</creatorcontrib><creatorcontrib>Julin, Per</creatorcontrib><creatorcontrib>Bartfai, Aniko</creatorcontrib><creatorcontrib>Hashim, Farouk</creatorcontrib><creatorcontrib>Li, Tie-Qiang</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nordin, Love Engström</au><au>Möller, Marika Christina</au><au>Julin, Per</au><au>Bartfai, Aniko</au><au>Hashim, Farouk</au><au>Li, Tie-Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post mTBI fatigue is associated with abnormal brain functional connectivity</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-02-16</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>21183</spage><epage>21183</epage><pages>21183-21183</pages><artnum>21183</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>This study set out to investigate the behavioral correlates of changes in resting-state functional connectivity before and after performing a 20 minute continuous psychomotor vigilance task (PVT) for patients with chronic post-concussion syndrome. 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| subjects | 59/57 692/617/375/1345 692/700/1421/1628 Adult Analysis of Variance Attention Brain Mapping Case-Control Studies Chronic Traumatic Encephalopathy - complications Chronic Traumatic Encephalopathy - diagnosis Chronic Traumatic Encephalopathy - physiopathology Concussion Cortex (frontal) Data processing Fatigue Fatigue - diagnosis Fatigue - etiology Female Functional magnetic resonance imaging Humanities and Social Sciences Humans Magnetic Resonance Imaging Male Medicin och hälsovetenskap Middle Aged multidisciplinary Neural networks Psychomotor Performance Science Science (multidisciplinary) Thalamus Traumatic brain injury Vigilance Young Adult |
| title | Post mTBI fatigue is associated with abnormal brain functional connectivity |
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