Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny

Variability in drug-metabolizing enzyme developmental trajectories contributes to interindividual differences in susceptibility to chemical toxicity and adverse drug reactions, particularly in the first years of life. Factors linked to these interindividual differences are largely unknown, but molec...

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Veröffentlicht in:	Drug metabolism and disposition 2016-07, Vol.44 (7), p.1027-1037
Hauptverfasser:	Giebel, Nicholas L, Shadley, Jeffrey D, McCarver, D Gail, Dorko, Kenneth, Gramignoli, Roberto, Strom, Stephen C, Yan, Ke, Simpson, Pippa M, Hines, Ronald N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Binding Sites Child Child, Preschool Chromatin - chemistry Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly Cytochrome P-450 CYP3A - genetics Cytochrome P-450 CYP3A - metabolism Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Gestational Age Hepatocytes - enzymology Histones - chemistry Histones - genetics Histones - metabolism Humans Infant Liver - embryology Liver - enzymology Medicin och hälsovetenskap Middle Aged Nucleic Acid Conformation Promoter Regions, Genetic Protein Conformation Special Section on Pediatric Drug Disposition and Pharmacokinetics Structure-Activity Relationship Transcription, Genetic
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