Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue
Psoriasis is an immune-mediated inflammatory disease, which is associated with a high risk of developing systemic comorbidities, such as obesity, cardiovascular disease, and diabetes mellitus. However, the mechanistic links between psoriatic skin inflammation and systemic comorbidities remain largel...
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| Veröffentlicht in: | Journal of investigative dermatology 2016-03, Vol.136 (3), p.640-648 |
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| creator | Cheung, Louisa Fisher, Rachel M. Kuzmina, Natalia Li, Dongqing Li, Xi Werngren, Olivera Blomqvist, Lennart Ståhle, Mona Landén, Ning Xu |
| description | Psoriasis is an immune-mediated inflammatory disease, which is associated with a high risk of developing systemic comorbidities, such as obesity, cardiovascular disease, and diabetes mellitus. However, the mechanistic links between psoriatic skin inflammation and systemic comorbidities remain largely unknown. MicroRNAs (miRNAs) are recently discovered gene regulators that play important roles in psoriasis skin inflammation. In this study we aimed to explore whether the skin inflammation in psoriasis affects miRNA expression of the underlying subcutaneous adipose tissue and whether this may be a link between psoriasis and comorbidities. To this end, we compared the miRNA expression profile of subcutaneous adipose tissue underneath lesional and nonlesional psoriatic skin. We further validated the differential expression of several miRNAs and characterized their expression patterns in different cell types present in subcutaneous adipose tissue. We focused on miR-26b-5p, which was highly up-regulated in subcutaneous adipose tissue underneath lesional psoriasis skin. We showed that it targets and down-regulates neutral cholesterol ester hydrolase 1, an enzyme essential for cholesterol efflux, in monocytes/macrophages, adipocytes, vascular endothelial cells, and fibroblasts. We conclude that this miRNA may serve as a mechanistic link between psoriatic skin inflammation and its systemic comorbidities. |
| doi_str_mv | 10.1016/j.jid.2015.12.008 |
| format | Article |
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However, the mechanistic links between psoriatic skin inflammation and systemic comorbidities remain largely unknown. MicroRNAs (miRNAs) are recently discovered gene regulators that play important roles in psoriasis skin inflammation. In this study we aimed to explore whether the skin inflammation in psoriasis affects miRNA expression of the underlying subcutaneous adipose tissue and whether this may be a link between psoriasis and comorbidities. To this end, we compared the miRNA expression profile of subcutaneous adipose tissue underneath lesional and nonlesional psoriatic skin. We further validated the differential expression of several miRNAs and characterized their expression patterns in different cell types present in subcutaneous adipose tissue. We focused on miR-26b-5p, which was highly up-regulated in subcutaneous adipose tissue underneath lesional psoriasis skin. We showed that it targets and down-regulates neutral cholesterol ester hydrolase 1, an enzyme essential for cholesterol efflux, in monocytes/macrophages, adipocytes, vascular endothelial cells, and fibroblasts. We conclude that this miRNA may serve as a mechanistic link between psoriatic skin inflammation and its systemic comorbidities.</description><identifier>ISSN: 0022-202X</identifier><identifier>ISSN: 1523-1747</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1016/j.jid.2015.12.008</identifier><identifier>PMID: 27015452</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Analysis of Variance ; Carboxylic Ester Hydrolases - genetics ; Comorbidity ; Female ; Gene Expression Profiling ; Humans ; Male ; Medicin och hälsovetenskap ; MicroRNAs - genetics ; Middle Aged ; Obesity - diagnosis ; Obesity - epidemiology ; Psoriasis - epidemiology ; Psoriasis - genetics ; Psoriasis - immunology ; Psoriasis - physiopathology ; Sampling Studies ; Subcutaneous Fat - immunology ; Subcutaneous Fat - metabolism ; Up-Regulation</subject><ispartof>Journal of investigative dermatology, 2016-03, Vol.136 (3), p.640-648</ispartof><rights>2015 The Authors</rights><rights>Copyright © 2015 The Authors. Published by Elsevier Inc. 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However, the mechanistic links between psoriatic skin inflammation and systemic comorbidities remain largely unknown. MicroRNAs (miRNAs) are recently discovered gene regulators that play important roles in psoriasis skin inflammation. In this study we aimed to explore whether the skin inflammation in psoriasis affects miRNA expression of the underlying subcutaneous adipose tissue and whether this may be a link between psoriasis and comorbidities. To this end, we compared the miRNA expression profile of subcutaneous adipose tissue underneath lesional and nonlesional psoriatic skin. We further validated the differential expression of several miRNAs and characterized their expression patterns in different cell types present in subcutaneous adipose tissue. We focused on miR-26b-5p, which was highly up-regulated in subcutaneous adipose tissue underneath lesional psoriasis skin. We showed that it targets and down-regulates neutral cholesterol ester hydrolase 1, an enzyme essential for cholesterol efflux, in monocytes/macrophages, adipocytes, vascular endothelial cells, and fibroblasts. We conclude that this miRNA may serve as a mechanistic link between psoriatic skin inflammation and its systemic comorbidities.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Carboxylic Ester Hydrolases - genetics</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Humans</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Obesity - diagnosis</subject><subject>Obesity - epidemiology</subject><subject>Psoriasis - epidemiology</subject><subject>Psoriasis - genetics</subject><subject>Psoriasis - immunology</subject><subject>Psoriasis - physiopathology</subject><subject>Sampling Studies</subject><subject>Subcutaneous Fat - immunology</subject><subject>Subcutaneous Fat - metabolism</subject><subject>Up-Regulation</subject><issn>0022-202X</issn><issn>1523-1747</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kU1v1DAQhi0EokvhB3BBOXJJ8IydOBGn1arQlaqC6FbiZjnxpHibj8VOQP33eJVtOcHJI_t5xtL7MvYWeAYcig_7bO9shhzyDDDjvHzGVpCjSEFJ9ZytOEdMkeP3M_YqhD2PjszLl-wMVXRkjiv242sYvTPBheTm3g3Jdmg70_dmcuOQbgc7N2ST3jV-_Ha9TrGok53xdzSF5HpzcQlJVG4HS757cMNdcjPXzTyZgcY5JGvrDmOgZOdCmOk1e9GaLtCb03nObj9d7DaX6dWXz9vN-iptZCmnFKwQolW5UoobalusTK5kAVKhqdRxLsGiMrIlUlVtS2iEJKxzZayIT-Kcpcve8JsOc60P3vXGP-jROH26uo8T6ZwXqCDy1T_5gx_tX-lRBCE4LyqF0X2_uBH8OVOYdO9CQ123JKBBqaLAUqCIKCxoTDIET-3TR8D1sUy917FMfSxTA-pYZnTendbPdU_2yXhsLwIfF4BioL8ceR0aR0OszHlqJm1H95_1fwDqQrA2</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Cheung, Louisa</creator><creator>Fisher, Rachel M.</creator><creator>Kuzmina, Natalia</creator><creator>Li, Dongqing</creator><creator>Li, Xi</creator><creator>Werngren, Olivera</creator><creator>Blomqvist, Lennart</creator><creator>Ståhle, Mona</creator><creator>Landén, Ning Xu</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-4868-3798</orcidid></search><sort><creationdate>20160301</creationdate><title>Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue</title><author>Cheung, Louisa ; Fisher, Rachel M. ; Kuzmina, Natalia ; Li, Dongqing ; Li, Xi ; Werngren, Olivera ; Blomqvist, Lennart ; Ståhle, Mona ; Landén, Ning Xu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-1d333f757770aeff29a57461472a97a57481d27a4fee79bd81c34e2b57ad381d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Carboxylic Ester Hydrolases - genetics</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Humans</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Obesity - diagnosis</topic><topic>Obesity - epidemiology</topic><topic>Psoriasis - epidemiology</topic><topic>Psoriasis - genetics</topic><topic>Psoriasis - immunology</topic><topic>Psoriasis - physiopathology</topic><topic>Sampling Studies</topic><topic>Subcutaneous Fat - immunology</topic><topic>Subcutaneous Fat - metabolism</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheung, Louisa</creatorcontrib><creatorcontrib>Fisher, Rachel M.</creatorcontrib><creatorcontrib>Kuzmina, Natalia</creatorcontrib><creatorcontrib>Li, Dongqing</creatorcontrib><creatorcontrib>Li, Xi</creatorcontrib><creatorcontrib>Werngren, Olivera</creatorcontrib><creatorcontrib>Blomqvist, Lennart</creatorcontrib><creatorcontrib>Ståhle, Mona</creatorcontrib><creatorcontrib>Landén, Ning Xu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheung, Louisa</au><au>Fisher, Rachel M.</au><au>Kuzmina, Natalia</au><au>Li, Dongqing</au><au>Li, Xi</au><au>Werngren, Olivera</au><au>Blomqvist, Lennart</au><au>Ståhle, Mona</au><au>Landén, Ning Xu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>136</volume><issue>3</issue><spage>640</spage><epage>648</epage><pages>640-648</pages><issn>0022-202X</issn><issn>1523-1747</issn><eissn>1523-1747</eissn><abstract>Psoriasis is an immune-mediated inflammatory disease, which is associated with a high risk of developing systemic comorbidities, such as obesity, cardiovascular disease, and diabetes mellitus. However, the mechanistic links between psoriatic skin inflammation and systemic comorbidities remain largely unknown. MicroRNAs (miRNAs) are recently discovered gene regulators that play important roles in psoriasis skin inflammation. In this study we aimed to explore whether the skin inflammation in psoriasis affects miRNA expression of the underlying subcutaneous adipose tissue and whether this may be a link between psoriasis and comorbidities. To this end, we compared the miRNA expression profile of subcutaneous adipose tissue underneath lesional and nonlesional psoriatic skin. We further validated the differential expression of several miRNAs and characterized their expression patterns in different cell types present in subcutaneous adipose tissue. We focused on miR-26b-5p, which was highly up-regulated in subcutaneous adipose tissue underneath lesional psoriasis skin. We showed that it targets and down-regulates neutral cholesterol ester hydrolase 1, an enzyme essential for cholesterol efflux, in monocytes/macrophages, adipocytes, vascular endothelial cells, and fibroblasts. We conclude that this miRNA may serve as a mechanistic link between psoriatic skin inflammation and its systemic comorbidities.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27015452</pmid><doi>10.1016/j.jid.2015.12.008</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4868-3798</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of investigative dermatology, 2016-03, Vol.136 (3), p.640-648 |
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| language | eng |
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| source | MEDLINE; SWEPUB Freely available online; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Aged Analysis of Variance Carboxylic Ester Hydrolases - genetics Comorbidity Female Gene Expression Profiling Humans Male Medicin och hälsovetenskap MicroRNAs - genetics Middle Aged Obesity - diagnosis Obesity - epidemiology Psoriasis - epidemiology Psoriasis - genetics Psoriasis - immunology Psoriasis - physiopathology Sampling Studies Subcutaneous Fat - immunology Subcutaneous Fat - metabolism Up-Regulation |
| title | Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue |
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