Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans
Physical exercise has emerged as an alternative treatment for patients with depressive disorder. Recent animal studies show that exercise protects from depression by increased skeletal muscle kynurenine aminotransferase (KAT) expression which shifts the kynurenine metabolism away from the neurotoxic...
Gespeichert in:
| Veröffentlicht in: | American Journal of Physiology: Cell Physiology 2016-05, Vol.310 (10), p.C836-C840 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | C840 |
|---|---|
| container_issue | 10 |
| container_start_page | C836 |
| container_title | American Journal of Physiology: Cell Physiology |
| container_volume | 310 |
| creator | Schlittler, Maja Goiny, Michel Agudelo, Leandro Z Venckunas, Tomas Brazaitis, Marius Skurvydas, Albertas Kamandulis, Sigitas Ruas, Jorge L Erhardt, Sophie Westerblad, Håkan Andersson, Daniel C |
| description | Physical exercise has emerged as an alternative treatment for patients with depressive disorder. Recent animal studies show that exercise protects from depression by increased skeletal muscle kynurenine aminotransferase (KAT) expression which shifts the kynurenine metabolism away from the neurotoxic kynurenine (KYN) to the production of kynurenic acid (KYNA). In the present study, we investigated the effect of exercise on kynurenine metabolism in humans. KAT gene and protein expression was increased in the muscles of endurance-trained subjects compared with untrained subjects. Endurance exercise caused an increase in plasma KYNA within the first hour after exercise. In contrast, a bout of high-intensity eccentric exercise did not lead to increased plasma KYNA concentration. Our results show that regular endurance exercise causes adaptations in kynurenine metabolism which can have implications for exercise recommendations for patients with depressive disorder. |
| doi_str_mv | 10.1152/ajpcell.00053.2016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_506195</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1789496416</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-a8aaeb54b50372b039c24d86f17a9de621192b40822cec17bed355f290df77023</originalsourceid><addsrcrecordid>eNqNkcFu3CAURVHVqpmk_YEuKqRuuvGUBwbMsoqSJlKkbNo1wvhZ9YyNXRjU5O_DZCazyCorEJx79eAQ8gXYGkDyH26zeBzHNWNMijVnoN6RVbngFUgl3pMVE0pUCmpxRs5T2hSu5sp8JGdcM8GklisyXYUuRxc8UnzA6IeEdAg-okuYaNriiDs30iknPyLdPoYcMQwBqZuGMO9KMvUYn2EXOrqMLk3uxHnq_NCVQvo3TwX9RD70bkz4-bhekD_XV78vb6q7-1-3lz_vKl-rZle5xjlsZd1KJjRvmTCe112jetDOdKg4gOFtzRrOPXrQLXZCyp4b1vVaMy4uSHXoTf9xya1d4jC5-GhnN9jj0bbs0EqmwMjCfz_wS5z_ZUw7Ow1p_7cu4JyThQag0cqwN6C6MbVRNaiCfnuFbuYcQ3l4oQw0Rkuzn5UfKB_nlCL2p2mB2b1ne_Rsnz3bvecS-nqszu2E3SnyIlY8AZtmpqY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1791897592</pqid></control><display><type>article</type><title>Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Schlittler, Maja ; Goiny, Michel ; Agudelo, Leandro Z ; Venckunas, Tomas ; Brazaitis, Marius ; Skurvydas, Albertas ; Kamandulis, Sigitas ; Ruas, Jorge L ; Erhardt, Sophie ; Westerblad, Håkan ; Andersson, Daniel C</creator><creatorcontrib>Schlittler, Maja ; Goiny, Michel ; Agudelo, Leandro Z ; Venckunas, Tomas ; Brazaitis, Marius ; Skurvydas, Albertas ; Kamandulis, Sigitas ; Ruas, Jorge L ; Erhardt, Sophie ; Westerblad, Håkan ; Andersson, Daniel C</creatorcontrib><description>Physical exercise has emerged as an alternative treatment for patients with depressive disorder. Recent animal studies show that exercise protects from depression by increased skeletal muscle kynurenine aminotransferase (KAT) expression which shifts the kynurenine metabolism away from the neurotoxic kynurenine (KYN) to the production of kynurenic acid (KYNA). In the present study, we investigated the effect of exercise on kynurenine metabolism in humans. KAT gene and protein expression was increased in the muscles of endurance-trained subjects compared with untrained subjects. Endurance exercise caused an increase in plasma KYNA within the first hour after exercise. In contrast, a bout of high-intensity eccentric exercise did not lead to increased plasma KYNA concentration. Our results show that regular endurance exercise causes adaptations in kynurenine metabolism which can have implications for exercise recommendations for patients with depressive disorder.</description><identifier>ISSN: 0363-6143</identifier><identifier>EISSN: 1522-1563</identifier><identifier>DOI: 10.1152/ajpcell.00053.2016</identifier><identifier>PMID: 27030575</identifier><identifier>CODEN: AJPCDD</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Exercise ; Exercise - physiology ; Gene expression ; Humans ; Kynurenic Acid - blood ; Male ; Mental depression ; Metabolism ; Muscle, Skeletal - physiology ; Musculoskeletal system ; Physical Conditioning, Human - methods ; Physical Conditioning, Human - physiology ; Physical Endurance - physiology ; Protein expression ; Transaminases - metabolism ; Up-Regulation - physiology ; Young Adult</subject><ispartof>American Journal of Physiology: Cell Physiology, 2016-05, Vol.310 (10), p.C836-C840</ispartof><rights>Copyright © 2016 the American Physiological Society.</rights><rights>Copyright American Physiological Society May 15, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-a8aaeb54b50372b039c24d86f17a9de621192b40822cec17bed355f290df77023</citedby><cites>FETCH-LOGICAL-c468t-a8aaeb54b50372b039c24d86f17a9de621192b40822cec17bed355f290df77023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27030575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:134307692$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Schlittler, Maja</creatorcontrib><creatorcontrib>Goiny, Michel</creatorcontrib><creatorcontrib>Agudelo, Leandro Z</creatorcontrib><creatorcontrib>Venckunas, Tomas</creatorcontrib><creatorcontrib>Brazaitis, Marius</creatorcontrib><creatorcontrib>Skurvydas, Albertas</creatorcontrib><creatorcontrib>Kamandulis, Sigitas</creatorcontrib><creatorcontrib>Ruas, Jorge L</creatorcontrib><creatorcontrib>Erhardt, Sophie</creatorcontrib><creatorcontrib>Westerblad, Håkan</creatorcontrib><creatorcontrib>Andersson, Daniel C</creatorcontrib><title>Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans</title><title>American Journal of Physiology: Cell Physiology</title><addtitle>Am J Physiol Cell Physiol</addtitle><description>Physical exercise has emerged as an alternative treatment for patients with depressive disorder. Recent animal studies show that exercise protects from depression by increased skeletal muscle kynurenine aminotransferase (KAT) expression which shifts the kynurenine metabolism away from the neurotoxic kynurenine (KYN) to the production of kynurenic acid (KYNA). In the present study, we investigated the effect of exercise on kynurenine metabolism in humans. KAT gene and protein expression was increased in the muscles of endurance-trained subjects compared with untrained subjects. Endurance exercise caused an increase in plasma KYNA within the first hour after exercise. In contrast, a bout of high-intensity eccentric exercise did not lead to increased plasma KYNA concentration. Our results show that regular endurance exercise causes adaptations in kynurenine metabolism which can have implications for exercise recommendations for patients with depressive disorder.</description><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Kynurenic Acid - blood</subject><subject>Male</subject><subject>Mental depression</subject><subject>Metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>Musculoskeletal system</subject><subject>Physical Conditioning, Human - methods</subject><subject>Physical Conditioning, Human - physiology</subject><subject>Physical Endurance - physiology</subject><subject>Protein expression</subject><subject>Transaminases - metabolism</subject><subject>Up-Regulation - physiology</subject><subject>Young Adult</subject><issn>0363-6143</issn><issn>1522-1563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu3CAURVHVqpmk_YEuKqRuuvGUBwbMsoqSJlKkbNo1wvhZ9YyNXRjU5O_DZCazyCorEJx79eAQ8gXYGkDyH26zeBzHNWNMijVnoN6RVbngFUgl3pMVE0pUCmpxRs5T2hSu5sp8JGdcM8GklisyXYUuRxc8UnzA6IeEdAg-okuYaNriiDs30iknPyLdPoYcMQwBqZuGMO9KMvUYn2EXOrqMLk3uxHnq_NCVQvo3TwX9RD70bkz4-bhekD_XV78vb6q7-1-3lz_vKl-rZle5xjlsZd1KJjRvmTCe112jetDOdKg4gOFtzRrOPXrQLXZCyp4b1vVaMy4uSHXoTf9xya1d4jC5-GhnN9jj0bbs0EqmwMjCfz_wS5z_ZUw7Ow1p_7cu4JyThQag0cqwN6C6MbVRNaiCfnuFbuYcQ3l4oQw0Rkuzn5UfKB_nlCL2p2mB2b1ne_Rsnz3bvecS-nqszu2E3SnyIlY8AZtmpqY</recordid><startdate>20160515</startdate><enddate>20160515</enddate><creator>Schlittler, Maja</creator><creator>Goiny, Michel</creator><creator>Agudelo, Leandro Z</creator><creator>Venckunas, Tomas</creator><creator>Brazaitis, Marius</creator><creator>Skurvydas, Albertas</creator><creator>Kamandulis, Sigitas</creator><creator>Ruas, Jorge L</creator><creator>Erhardt, Sophie</creator><creator>Westerblad, Håkan</creator><creator>Andersson, Daniel C</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20160515</creationdate><title>Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans</title><author>Schlittler, Maja ; Goiny, Michel ; Agudelo, Leandro Z ; Venckunas, Tomas ; Brazaitis, Marius ; Skurvydas, Albertas ; Kamandulis, Sigitas ; Ruas, Jorge L ; Erhardt, Sophie ; Westerblad, Håkan ; Andersson, Daniel C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-a8aaeb54b50372b039c24d86f17a9de621192b40822cec17bed355f290df77023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Kynurenic Acid - blood</topic><topic>Male</topic><topic>Mental depression</topic><topic>Metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>Musculoskeletal system</topic><topic>Physical Conditioning, Human - methods</topic><topic>Physical Conditioning, Human - physiology</topic><topic>Physical Endurance - physiology</topic><topic>Protein expression</topic><topic>Transaminases - metabolism</topic><topic>Up-Regulation - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schlittler, Maja</creatorcontrib><creatorcontrib>Goiny, Michel</creatorcontrib><creatorcontrib>Agudelo, Leandro Z</creatorcontrib><creatorcontrib>Venckunas, Tomas</creatorcontrib><creatorcontrib>Brazaitis, Marius</creatorcontrib><creatorcontrib>Skurvydas, Albertas</creatorcontrib><creatorcontrib>Kamandulis, Sigitas</creatorcontrib><creatorcontrib>Ruas, Jorge L</creatorcontrib><creatorcontrib>Erhardt, Sophie</creatorcontrib><creatorcontrib>Westerblad, Håkan</creatorcontrib><creatorcontrib>Andersson, Daniel C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>American Journal of Physiology: Cell Physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schlittler, Maja</au><au>Goiny, Michel</au><au>Agudelo, Leandro Z</au><au>Venckunas, Tomas</au><au>Brazaitis, Marius</au><au>Skurvydas, Albertas</au><au>Kamandulis, Sigitas</au><au>Ruas, Jorge L</au><au>Erhardt, Sophie</au><au>Westerblad, Håkan</au><au>Andersson, Daniel C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans</atitle><jtitle>American Journal of Physiology: Cell Physiology</jtitle><addtitle>Am J Physiol Cell Physiol</addtitle><date>2016-05-15</date><risdate>2016</risdate><volume>310</volume><issue>10</issue><spage>C836</spage><epage>C840</epage><pages>C836-C840</pages><issn>0363-6143</issn><eissn>1522-1563</eissn><coden>AJPCDD</coden><abstract>Physical exercise has emerged as an alternative treatment for patients with depressive disorder. Recent animal studies show that exercise protects from depression by increased skeletal muscle kynurenine aminotransferase (KAT) expression which shifts the kynurenine metabolism away from the neurotoxic kynurenine (KYN) to the production of kynurenic acid (KYNA). In the present study, we investigated the effect of exercise on kynurenine metabolism in humans. KAT gene and protein expression was increased in the muscles of endurance-trained subjects compared with untrained subjects. Endurance exercise caused an increase in plasma KYNA within the first hour after exercise. In contrast, a bout of high-intensity eccentric exercise did not lead to increased plasma KYNA concentration. Our results show that regular endurance exercise causes adaptations in kynurenine metabolism which can have implications for exercise recommendations for patients with depressive disorder.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>27030575</pmid><doi>10.1152/ajpcell.00053.2016</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6143 |
| ispartof | American Journal of Physiology: Cell Physiology, 2016-05, Vol.310 (10), p.C836-C840 |
| issn | 0363-6143 1522-1563 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_506195 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Exercise Exercise - physiology Gene expression Humans Kynurenic Acid - blood Male Mental depression Metabolism Muscle, Skeletal - physiology Musculoskeletal system Physical Conditioning, Human - methods Physical Conditioning, Human - physiology Physical Endurance - physiology Protein expression Transaminases - metabolism Up-Regulation - physiology Young Adult |
| title | Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T06%3A43%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endurance%20exercise%20increases%20skeletal%20muscle%20kynurenine%20aminotransferases%20and%20plasma%20kynurenic%20acid%20in%20humans&rft.jtitle=American%20Journal%20of%20Physiology:%20Cell%20Physiology&rft.au=Schlittler,%20Maja&rft.date=2016-05-15&rft.volume=310&rft.issue=10&rft.spage=C836&rft.epage=C840&rft.pages=C836-C840&rft.issn=0363-6143&rft.eissn=1522-1563&rft.coden=AJPCDD&rft_id=info:doi/10.1152/ajpcell.00053.2016&rft_dat=%3Cproquest_swepu%3E1789496416%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1791897592&rft_id=info:pmid/27030575&rfr_iscdi=true |