Bioenergetic roles of mitochondrial fusion
Mitochondria are bioenergetic hotspots, producing the bulk of ATP by the oxidative phosphorylation process. Mitochondria are also structurally dynamic and undergo coordinated fusion and fission to maintain their function. Recent studies of the mitochondrial fusion machinery have provided new evidenc...
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| Veröffentlicht in: | Biochimica et biophysica acta 2016-08, Vol.1857 (8), p.1277-1283 |
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| creator | Silva Ramos, Eduardo Larsson, Nils-Göran Mourier, Arnaud |
| description | Mitochondria are bioenergetic hotspots, producing the bulk of ATP by the oxidative phosphorylation process. Mitochondria are also structurally dynamic and undergo coordinated fusion and fission to maintain their function. Recent studies of the mitochondrial fusion machinery have provided new evidence in detailing their role in mitochondrial metabolism. Remarkably, mitofusin 2, in addition to its role in fusion, is important for maintaining coenzyme Q levels and may be an integral player in the mevalonate synthesis pathway. Here, we review the bioenergetic roles of mitochondrial dynamics and emphasize the importance of the in vitro growth conditions when evaluating mitochondrial respiration. This article is part of a Special Issue entitled ‘EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2–6, 2016,’ edited by Prof. Paolo Bernardi.
•Mitochondria form a dynamic network within the cell as a result of balanced fusion and fission.•Mitochondrial dynamics and OXPHOS activity are highly interdependent.•Specific cell culture conditions are required to reveal Mfn2 KO MEFs bioenergetics defects. |
| doi_str_mv | 10.1016/j.bbabio.2016.04.002 |
| format | Article |
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Larsson, Nils-Göran ; Mourier, Arnaud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-2903fd7ddb468224e7ebc5c839bc42d88521c9f34021477ea21588d7c0aa95023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bioenergetics</topic><topic>Cell Line, Transformed</topic><topic>Coenzyme Q</topic><topic>Eye Proteins - genetics</topic><topic>Eye Proteins - metabolism</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - drug effects</topic><topic>Fibroblasts - metabolism</topic><topic>Gene Expression</topic><topic>Genome, Mitochondrial</topic><topic>GTP Phosphohydrolases - deficiency</topic><topic>GTP Phosphohydrolases - genetics</topic><topic>GTP Phosphohydrolases - metabolism</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Mevalonate pathway</topic><topic>Mevalonic Acid - metabolism</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mitochondria - metabolism</topic><topic>Mitochondrial dynamics</topic><topic>Mitochondrial Dynamics - genetics</topic><topic>Mitofusin 2</topic><topic>Oxidative Phosphorylation</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Ubiquinone - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva Ramos, Eduardo</creatorcontrib><creatorcontrib>Larsson, Nils-Göran</creatorcontrib><creatorcontrib>Mourier, Arnaud</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Conference</collection><collection>SwePub Conference full text</collection><collection>SWEPUB Freely available online</collection><jtitle>Biochimica et biophysica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva Ramos, Eduardo</au><au>Larsson, Nils-Göran</au><au>Mourier, Arnaud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioenergetic roles of mitochondrial fusion</atitle><jtitle>Biochimica et biophysica acta</jtitle><addtitle>Biochim Biophys Acta</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>1857</volume><issue>8</issue><spage>1277</spage><epage>1283</epage><pages>1277-1283</pages><issn>0005-2728</issn><issn>0006-3002</issn><eissn>1879-2650</eissn><abstract>Mitochondria are bioenergetic hotspots, producing the bulk of ATP by the oxidative phosphorylation process. Mitochondria are also structurally dynamic and undergo coordinated fusion and fission to maintain their function. Recent studies of the mitochondrial fusion machinery have provided new evidence in detailing their role in mitochondrial metabolism. Remarkably, mitofusin 2, in addition to its role in fusion, is important for maintaining coenzyme Q levels and may be an integral player in the mevalonate synthesis pathway. Here, we review the bioenergetic roles of mitochondrial dynamics and emphasize the importance of the in vitro growth conditions when evaluating mitochondrial respiration. This article is part of a Special Issue entitled ‘EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2–6, 2016,’ edited by Prof. Paolo Bernardi.
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| subjects | Animals Bioenergetics Cell Line, Transformed Coenzyme Q Eye Proteins - genetics Eye Proteins - metabolism Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Genome, Mitochondrial GTP Phosphohydrolases - deficiency GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mevalonate pathway Mevalonic Acid - metabolism Mice Mice, Knockout Mitochondria - metabolism Mitochondrial dynamics Mitochondrial Dynamics - genetics Mitofusin 2 Oxidative Phosphorylation Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Ubiquinone - metabolism |
| title | Bioenergetic roles of mitochondrial fusion |
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