Human macrophages induce CD4+Foxp3+ regulatory T cells via binding and re‐release of TGF‐β

While pro‐inflammatory immune responses are a requirement to combat microbes, uncontrolled self‐directed inflammatory immune responses are the hallmark of autoimmune diseases. Restoration of immunological tolerance involves both suppression of ongoing tissue‐destructive immune responses and re‐educa...

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Veröffentlicht in:	Immunology and cell biology 2016-09, Vol.94 (8), p.747-762
Hauptverfasser:	Schmidt, Angelika, Zhang, Xing‐Mei, Joshi, Rubin N, Iqbal, Shasina, Wahlund, Casper, Gabrielsson, Susanne, Harris, Robert A, Tegnér, Jesper
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation Cell Polarity Cytokines - metabolism DNA Demethylation Exosomes - metabolism Forkhead Transcription Factors - metabolism Humans Inflammation Mediators - metabolism Macrophages - metabolism Medicin och hälsovetenskap Protein Stability T-Lymphocytes, Regulatory - immunology Transforming Growth Factor beta - metabolism
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