Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults
Objective To investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults. Methods We performed a nationwide matched (age, sex, and case event day) case–control study between 1 January and 31 D...
Gespeichert in:
| Veröffentlicht in: | International journal of geriatric psychiatry 2017-04, Vol.32 (4), p.414-420 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 420 |
|---|---|
| container_issue | 4 |
| container_start_page | 414 |
| container_title | International journal of geriatric psychiatry |
| container_volume | 32 |
| creator | Johnell, Kristina Jonasdottir Bergman, Gudrun Fastbom, Johan Danielsson, Bengt Borg, Natalia Salmi, Peter |
| description | Objective
To investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults.
Methods
We performed a nationwide matched (age, sex, and case event day) case–control study between 1 January and 31 December 2011 based on several Swedish registers (n = 1,288,875 persons aged ≥65 years). We used multivariate conditional logistic regression adjusted for education, number of inpatient days, Charlson co‐morbidity index, dementia and number of other drugs.
Results
Antidepressants were the psychotropic most strongly related to fall injuries (ORadjusted: 1.42; 95% CI: 1.38–1.45) and antipsychotics to hospitalizations (ORadjusted: 1.22; 95% CI: 1.19–1.24) and death (ORadjusted: 2.10; 95% CI: 2.02–2.17). Number of psychotropics was associated with increased the risk of fall injuries, (4 psychotropics vs 0: ORadjusted: 1.53; 95% CI: 1.39–1.68), hospitalization (4 psychotropics vs 0: ORadjusted: 1.27; 95% CI: 1.22–1.33) and death (4 psychotropics vs 0: ORadjusted: 2.50; 95% CI: 2.33–2.69) in a dose–response manner. Among persons with dementia (n = 58,984), a dose–response relationship was found between number of psychotropics and mortality risk (4 psychotropics vs 0: ORadjusted: 1.99; 95% CI: 1.76–2.25).
Conclusions
Our findings support a cautious prescribing of multiple psychotropic drugs to older patients. © 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/gps.4483 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_505629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1881761470</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6123-924ecc3e772e6820aaa4b9e0c9b88da79bfd22c2796804699d2f16b073d9fa483</originalsourceid><addsrcrecordid>eNp1kl1rFDEUhoModq2Cv0AC3njRqfmafNwIpWoVChb8uA2ZJDOb7cxkTGYs--_NumtrhV4lnPPk4eTwAvASo1OMEHnbTfmUMUkfgRVGSlUYc_4YrJCUdcUJRUfgWc4bhEoPy6fgiAiMqcR0BexV3tp1nFOcgoUuLV2GZnRwXnuYQr6GsYWt6XsYxs2Sgs8ncB3zFGbTh2zmEMc9P8S0K81baIY4djD2zido3NLP-Tl4UhTZvzicx-D7xw_fzj9Vl18uPp-fXVaWY0IrRZi3lnohiOeSIGMMa5RHVjVSOiNU0zpCLBGKS8S4Uo60mDdIUKdaU35_DKq9N9_4aWn0lMJg0lZHE_ShdF1uXteo5kQV_uRB_n34caZj6nReNGaUE1bwd3u8sIN31o9zMv29V_c7Y1jrLv7SNWVCMVEEbw6CFH8uPs96CNn6vjejj0vWWEosOGYCFfT1f-gmLmks2yuUqBEXVMo7oU0x5-Tb22Ew0rtg6BIMvQtGQV_9O_wt-DcJd8u7Cb3fPijSF1df_wh_A_PXxGA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1875067388</pqid></control><display><type>article</type><title>Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SWEPUB Freely available online</source><creator>Johnell, Kristina ; Jonasdottir Bergman, Gudrun ; Fastbom, Johan ; Danielsson, Bengt ; Borg, Natalia ; Salmi, Peter</creator><creatorcontrib>Johnell, Kristina ; Jonasdottir Bergman, Gudrun ; Fastbom, Johan ; Danielsson, Bengt ; Borg, Natalia ; Salmi, Peter</creatorcontrib><description>Objective
To investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults.
Methods
We performed a nationwide matched (age, sex, and case event day) case–control study between 1 January and 31 December 2011 based on several Swedish registers (n = 1,288,875 persons aged ≥65 years). We used multivariate conditional logistic regression adjusted for education, number of inpatient days, Charlson co‐morbidity index, dementia and number of other drugs.
Results
Antidepressants were the psychotropic most strongly related to fall injuries (ORadjusted: 1.42; 95% CI: 1.38–1.45) and antipsychotics to hospitalizations (ORadjusted: 1.22; 95% CI: 1.19–1.24) and death (ORadjusted: 2.10; 95% CI: 2.02–2.17). Number of psychotropics was associated with increased the risk of fall injuries, (4 psychotropics vs 0: ORadjusted: 1.53; 95% CI: 1.39–1.68), hospitalization (4 psychotropics vs 0: ORadjusted: 1.27; 95% CI: 1.22–1.33) and death (4 psychotropics vs 0: ORadjusted: 2.50; 95% CI: 2.33–2.69) in a dose–response manner. Among persons with dementia (n = 58,984), a dose–response relationship was found between number of psychotropics and mortality risk (4 psychotropics vs 0: ORadjusted: 1.99; 95% CI: 1.76–2.25).
Conclusions
Our findings support a cautious prescribing of multiple psychotropic drugs to older patients. © 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>ISSN: 1099-1166</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.4483</identifier><identifier>PMID: 27113813</identifier><identifier>CODEN: IJGPES</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Accidental Falls - statistics & numerical data ; Aged ; Aged, 80 and over ; Antidepressive Agents - adverse effects ; Antipsychotic Agents - therapeutic use ; Case-Control Studies ; Comorbidity ; Dementia ; Drug dosages ; Falls ; Female ; Geriatric psychiatry ; Geriatric psychology ; Hospitalization - statistics & numerical data ; Humans ; Logistic Models ; Male ; Mental Disorders - drug therapy ; Mortality ; Older people ; Psychotropic drugs ; Psychotropic Drugs - adverse effects ; Psychotropic Drugs - therapeutic use ; Risk factors ; Sweden ; Sweden - epidemiology</subject><ispartof>International journal of geriatric psychiatry, 2017-04, Vol.32 (4), p.414-420</ispartof><rights>2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6123-924ecc3e772e6820aaa4b9e0c9b88da79bfd22c2796804699d2f16b073d9fa483</citedby><cites>FETCH-LOGICAL-c6123-924ecc3e772e6820aaa4b9e0c9b88da79bfd22c2796804699d2f16b073d9fa483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.4483$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.4483$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27113813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-143624$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:135629842$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnell, Kristina</creatorcontrib><creatorcontrib>Jonasdottir Bergman, Gudrun</creatorcontrib><creatorcontrib>Fastbom, Johan</creatorcontrib><creatorcontrib>Danielsson, Bengt</creatorcontrib><creatorcontrib>Borg, Natalia</creatorcontrib><creatorcontrib>Salmi, Peter</creatorcontrib><title>Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults</title><title>International journal of geriatric psychiatry</title><addtitle>Int J Geriatr Psychiatry</addtitle><description>Objective
To investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults.
Methods
We performed a nationwide matched (age, sex, and case event day) case–control study between 1 January and 31 December 2011 based on several Swedish registers (n = 1,288,875 persons aged ≥65 years). We used multivariate conditional logistic regression adjusted for education, number of inpatient days, Charlson co‐morbidity index, dementia and number of other drugs.
Results
Antidepressants were the psychotropic most strongly related to fall injuries (ORadjusted: 1.42; 95% CI: 1.38–1.45) and antipsychotics to hospitalizations (ORadjusted: 1.22; 95% CI: 1.19–1.24) and death (ORadjusted: 2.10; 95% CI: 2.02–2.17). Number of psychotropics was associated with increased the risk of fall injuries, (4 psychotropics vs 0: ORadjusted: 1.53; 95% CI: 1.39–1.68), hospitalization (4 psychotropics vs 0: ORadjusted: 1.27; 95% CI: 1.22–1.33) and death (4 psychotropics vs 0: ORadjusted: 2.50; 95% CI: 2.33–2.69) in a dose–response manner. Among persons with dementia (n = 58,984), a dose–response relationship was found between number of psychotropics and mortality risk (4 psychotropics vs 0: ORadjusted: 1.99; 95% CI: 1.76–2.25).
Conclusions
Our findings support a cautious prescribing of multiple psychotropic drugs to older patients. © 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd.</description><subject>Accidental Falls - statistics & numerical data</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antidepressive Agents - adverse effects</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Case-Control Studies</subject><subject>Comorbidity</subject><subject>Dementia</subject><subject>Drug dosages</subject><subject>Falls</subject><subject>Female</subject><subject>Geriatric psychiatry</subject><subject>Geriatric psychology</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Mental Disorders - drug therapy</subject><subject>Mortality</subject><subject>Older people</subject><subject>Psychotropic drugs</subject><subject>Psychotropic Drugs - adverse effects</subject><subject>Psychotropic Drugs - therapeutic use</subject><subject>Risk factors</subject><subject>Sweden</subject><subject>Sweden - epidemiology</subject><issn>0885-6230</issn><issn>1099-1166</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kl1rFDEUhoModq2Cv0AC3njRqfmafNwIpWoVChb8uA2ZJDOb7cxkTGYs--_NumtrhV4lnPPk4eTwAvASo1OMEHnbTfmUMUkfgRVGSlUYc_4YrJCUdcUJRUfgWc4bhEoPy6fgiAiMqcR0BexV3tp1nFOcgoUuLV2GZnRwXnuYQr6GsYWt6XsYxs2Sgs8ncB3zFGbTh2zmEMc9P8S0K81baIY4djD2zido3NLP-Tl4UhTZvzicx-D7xw_fzj9Vl18uPp-fXVaWY0IrRZi3lnohiOeSIGMMa5RHVjVSOiNU0zpCLBGKS8S4Uo60mDdIUKdaU35_DKq9N9_4aWn0lMJg0lZHE_ShdF1uXteo5kQV_uRB_n34caZj6nReNGaUE1bwd3u8sIN31o9zMv29V_c7Y1jrLv7SNWVCMVEEbw6CFH8uPs96CNn6vjejj0vWWEosOGYCFfT1f-gmLmks2yuUqBEXVMo7oU0x5-Tb22Ew0rtg6BIMvQtGQV_9O_wt-DcJd8u7Cb3fPijSF1df_wh_A_PXxGA</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Johnell, Kristina</creator><creator>Jonasdottir Bergman, Gudrun</creator><creator>Fastbom, Johan</creator><creator>Danielsson, Bengt</creator><creator>Borg, Natalia</creator><creator>Salmi, Peter</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>5PM</scope><scope>ABAVF</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DG7</scope><scope>ZZAVC</scope></search><sort><creationdate>201704</creationdate><title>Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults</title><author>Johnell, Kristina ; Jonasdottir Bergman, Gudrun ; Fastbom, Johan ; Danielsson, Bengt ; Borg, Natalia ; Salmi, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6123-924ecc3e772e6820aaa4b9e0c9b88da79bfd22c2796804699d2f16b073d9fa483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Accidental Falls - statistics & numerical data</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antidepressive Agents - adverse effects</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Case-Control Studies</topic><topic>Comorbidity</topic><topic>Dementia</topic><topic>Drug dosages</topic><topic>Falls</topic><topic>Female</topic><topic>Geriatric psychiatry</topic><topic>Geriatric psychology</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Mental Disorders - drug therapy</topic><topic>Mortality</topic><topic>Older people</topic><topic>Psychotropic drugs</topic><topic>Psychotropic Drugs - adverse effects</topic><topic>Psychotropic Drugs - therapeutic use</topic><topic>Risk factors</topic><topic>Sweden</topic><topic>Sweden - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnell, Kristina</creatorcontrib><creatorcontrib>Jonasdottir Bergman, Gudrun</creatorcontrib><creatorcontrib>Fastbom, Johan</creatorcontrib><creatorcontrib>Danielsson, Bengt</creatorcontrib><creatorcontrib>Borg, Natalia</creatorcontrib><creatorcontrib>Salmi, Peter</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Stockholms universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Stockholms universitet</collection><collection>SwePub Articles full text</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnell, Kristina</au><au>Jonasdottir Bergman, Gudrun</au><au>Fastbom, Johan</au><au>Danielsson, Bengt</au><au>Borg, Natalia</au><au>Salmi, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int J Geriatr Psychiatry</addtitle><date>2017-04</date><risdate>2017</risdate><volume>32</volume><issue>4</issue><spage>414</spage><epage>420</epage><pages>414-420</pages><issn>0885-6230</issn><issn>1099-1166</issn><eissn>1099-1166</eissn><coden>IJGPES</coden><abstract>Objective
To investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults.
Methods
We performed a nationwide matched (age, sex, and case event day) case–control study between 1 January and 31 December 2011 based on several Swedish registers (n = 1,288,875 persons aged ≥65 years). We used multivariate conditional logistic regression adjusted for education, number of inpatient days, Charlson co‐morbidity index, dementia and number of other drugs.
Results
Antidepressants were the psychotropic most strongly related to fall injuries (ORadjusted: 1.42; 95% CI: 1.38–1.45) and antipsychotics to hospitalizations (ORadjusted: 1.22; 95% CI: 1.19–1.24) and death (ORadjusted: 2.10; 95% CI: 2.02–2.17). Number of psychotropics was associated with increased the risk of fall injuries, (4 psychotropics vs 0: ORadjusted: 1.53; 95% CI: 1.39–1.68), hospitalization (4 psychotropics vs 0: ORadjusted: 1.27; 95% CI: 1.22–1.33) and death (4 psychotropics vs 0: ORadjusted: 2.50; 95% CI: 2.33–2.69) in a dose–response manner. Among persons with dementia (n = 58,984), a dose–response relationship was found between number of psychotropics and mortality risk (4 psychotropics vs 0: ORadjusted: 1.99; 95% CI: 1.76–2.25).
Conclusions
Our findings support a cautious prescribing of multiple psychotropic drugs to older patients. © 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27113813</pmid><doi>10.1002/gps.4483</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-6230 |
| ispartof | International journal of geriatric psychiatry, 2017-04, Vol.32 (4), p.414-420 |
| issn | 0885-6230 1099-1166 1099-1166 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_505629 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online |
| subjects | Accidental Falls - statistics & numerical data Aged Aged, 80 and over Antidepressive Agents - adverse effects Antipsychotic Agents - therapeutic use Case-Control Studies Comorbidity Dementia Drug dosages Falls Female Geriatric psychiatry Geriatric psychology Hospitalization - statistics & numerical data Humans Logistic Models Male Mental Disorders - drug therapy Mortality Older people Psychotropic drugs Psychotropic Drugs - adverse effects Psychotropic Drugs - therapeutic use Risk factors Sweden Sweden - epidemiology |
| title | Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T09%3A46%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Psychotropic%20drugs%20and%20the%20risk%20of%20fall%20injuries,%20hospitalisations%20and%20mortality%20among%20older%20adults&rft.jtitle=International%20journal%20of%20geriatric%20psychiatry&rft.au=Johnell,%20Kristina&rft.date=2017-04&rft.volume=32&rft.issue=4&rft.spage=414&rft.epage=420&rft.pages=414-420&rft.issn=0885-6230&rft.eissn=1099-1166&rft.coden=IJGPES&rft_id=info:doi/10.1002/gps.4483&rft_dat=%3Cproquest_swepu%3E1881761470%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1875067388&rft_id=info:pmid/27113813&rfr_iscdi=true |