Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins

Dopamine receptors are G protein-coupled receptors involved in regulation of cognition, learning, movement and endocrine signaling. The action of G protein-coupled receptors is highly regulated by multifunctional proteins, such as β-arrestins which can control receptor desensitization, ubiquitinatio...

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Veröffentlicht in:	Cellular signalling 2016-08, Vol.28 (8), p.1001-1014
Hauptverfasser:	Skieterska, Kamila, Shen, Ao, Clarisse, Dorien, Rondou, Pieter, Borroto-Escuela, Dasiel Oscar, Lintermans, Béatrice, Fuxe, Kjell, Xiang, Yang Kevin, Van Craenenbroeck, Kathleen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Arrestins - metabolism Cullin Proteins - metabolism Dopamine - pharmacology dopamine D4 receptor GPCR GTP-Binding Proteins - metabolism HEK293 Cells Humans Kelch Repeat KLHL12 Mice Mice, Knockout Microfilament Proteins - chemistry Microfilament Proteins - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Models, Biological Mutant Proteins - metabolism Pertussis Toxin - pharmacology Phosphorylation - drug effects Protein Binding - drug effects Protein Domains Protein Multimerization - drug effects Receptors, Dopamine D4 - metabolism Ubiquitin-Protein Ligases - metabolism ubiquitination Ubiquitination - drug effects β-arrestin
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