Exogenous estrogen and the risk of biliary tract cancer - a population-based study in a cohort of Swedish men treated for prostate cancer
To assess the role of exogenous estrogen in the etiology of biliary tract cancer, a nationwide population-based cohort study in Sweden was performed. The study included all men in Sweden with prostate cancer diagnosed in 1961-2008. Due to treatment standards, patients diagnosed in 1961-1980 were con...
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| Veröffentlicht in: | Acta oncologica 2016-01, Vol.55 (7), p.846-850 |
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| creator | Kilander, Carl Mattsson, Fredrik Lu, Yunxia Ljung, Rickard Lagergren, Jesper Sadr-Azodi, Omid |
| description | To assess the role of exogenous estrogen in the etiology of biliary tract cancer, a nationwide population-based cohort study in Sweden was performed.
The study included all men in Sweden with prostate cancer diagnosed in 1961-2008. Due to treatment standards, patients diagnosed in 1961-1980 were considered more exposed to estrogen, while those diagnosed in 1981-2008 were regarded less exposed. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated to estimate the risk of biliary tract cancer in cohort members compared to the corresponding Swedish male population.
After 849 307 person-years of follow-up in 203 131 prostate cancer patients, there were 41 incident gallbladder cancers and 36 cancers of the extra-hepatic bile ducts. In overall, there were no apparent differences in the risk of gallbladder cancer or bile duct cancer between patients diagnosed in 1961-1980 and patients diagnosed in 1981-2008. However, in patients diagnosed in 1961-1980, there was a statistically non-significant increased risk of gallbladder cancer (SIR 1.34; 95% CI 0.71-2.29) and extra-hepatic bile duct cancer (SIR 1.20; 95% CI 0.55-2.28) > 5 years of follow-up after the prostate cancer diagnosis. No such association was found for patients diagnosed in 1981-2008. Sensitivity analyses excluding prostate cancer patients exposed to potential confounding factors did not change the SIRs.
Long exposure to high doses of exogenous estrogen might increase the risk of biliary tract cancer. However, any potential excess risk of bile duct cancer resulted by prolonged exposure to high doses of exogenous estrogen seems to be small. |
| doi_str_mv | 10.3109/0284186X.2015.1131333 |
| format | Article |
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The study included all men in Sweden with prostate cancer diagnosed in 1961-2008. Due to treatment standards, patients diagnosed in 1961-1980 were considered more exposed to estrogen, while those diagnosed in 1981-2008 were regarded less exposed. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated to estimate the risk of biliary tract cancer in cohort members compared to the corresponding Swedish male population.
After 849 307 person-years of follow-up in 203 131 prostate cancer patients, there were 41 incident gallbladder cancers and 36 cancers of the extra-hepatic bile ducts. In overall, there were no apparent differences in the risk of gallbladder cancer or bile duct cancer between patients diagnosed in 1961-1980 and patients diagnosed in 1981-2008. However, in patients diagnosed in 1961-1980, there was a statistically non-significant increased risk of gallbladder cancer (SIR 1.34; 95% CI 0.71-2.29) and extra-hepatic bile duct cancer (SIR 1.20; 95% CI 0.55-2.28) > 5 years of follow-up after the prostate cancer diagnosis. No such association was found for patients diagnosed in 1981-2008. Sensitivity analyses excluding prostate cancer patients exposed to potential confounding factors did not change the SIRs.
Long exposure to high doses of exogenous estrogen might increase the risk of biliary tract cancer. However, any potential excess risk of bile duct cancer resulted by prolonged exposure to high doses of exogenous estrogen seems to be small.</description><identifier>ISSN: 0284-186X</identifier><identifier>ISSN: 1651-226X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.3109/0284186X.2015.1131333</identifier><identifier>PMID: 27173637</identifier><language>eng</language><publisher>England</publisher><subject>Adenocarcinoma - therapy ; Aged ; Aged, 80 and over ; Biliary Tract Neoplasms - chemically induced ; Biliary Tract Neoplasms - epidemiology ; Biliary Tract Neoplasms - etiology ; Cohort Studies ; Estrogens - adverse effects ; Estrogens - therapeutic use ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - therapy ; Retrospective Studies ; Risk Factors ; Sweden - epidemiology</subject><ispartof>Acta oncologica, 2016-01, Vol.55 (7), p.846-850</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-5e037873fa43f41245a6682071e2ec3ddd2107f6739addbbe1e6a347fa6722303</citedby><cites>FETCH-LOGICAL-c431t-5e037873fa43f41245a6682071e2ec3ddd2107f6739addbbe1e6a347fa6722303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27173637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299619$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:133732739$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kilander, Carl</creatorcontrib><creatorcontrib>Mattsson, Fredrik</creatorcontrib><creatorcontrib>Lu, Yunxia</creatorcontrib><creatorcontrib>Ljung, Rickard</creatorcontrib><creatorcontrib>Lagergren, Jesper</creatorcontrib><creatorcontrib>Sadr-Azodi, Omid</creatorcontrib><title>Exogenous estrogen and the risk of biliary tract cancer - a population-based study in a cohort of Swedish men treated for prostate cancer</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>To assess the role of exogenous estrogen in the etiology of biliary tract cancer, a nationwide population-based cohort study in Sweden was performed.
The study included all men in Sweden with prostate cancer diagnosed in 1961-2008. Due to treatment standards, patients diagnosed in 1961-1980 were considered more exposed to estrogen, while those diagnosed in 1981-2008 were regarded less exposed. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated to estimate the risk of biliary tract cancer in cohort members compared to the corresponding Swedish male population.
After 849 307 person-years of follow-up in 203 131 prostate cancer patients, there were 41 incident gallbladder cancers and 36 cancers of the extra-hepatic bile ducts. In overall, there were no apparent differences in the risk of gallbladder cancer or bile duct cancer between patients diagnosed in 1961-1980 and patients diagnosed in 1981-2008. However, in patients diagnosed in 1961-1980, there was a statistically non-significant increased risk of gallbladder cancer (SIR 1.34; 95% CI 0.71-2.29) and extra-hepatic bile duct cancer (SIR 1.20; 95% CI 0.55-2.28) > 5 years of follow-up after the prostate cancer diagnosis. No such association was found for patients diagnosed in 1981-2008. Sensitivity analyses excluding prostate cancer patients exposed to potential confounding factors did not change the SIRs.
Long exposure to high doses of exogenous estrogen might increase the risk of biliary tract cancer. However, any potential excess risk of bile duct cancer resulted by prolonged exposure to high doses of exogenous estrogen seems to be small.</description><subject>Adenocarcinoma - therapy</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biliary Tract Neoplasms - chemically induced</subject><subject>Biliary Tract Neoplasms - epidemiology</subject><subject>Biliary Tract Neoplasms - etiology</subject><subject>Cohort Studies</subject><subject>Estrogens - adverse effects</subject><subject>Estrogens - therapeutic use</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sweden - epidemiology</subject><issn>0284-186X</issn><issn>1651-226X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EokPhEUBesiCD7RvbybIqpSBVYsGPurOc-KZjmokH21HpI_DWdTRpd6x8bX3nWPccQt5ytgXO2o9MNDVv1PVWMC63nAMHgGdkw5XklRDq-jnZLEy1QCfkVUq_GWMCtHxJToTmGhToDfl38Tfc4BTmRDHluMzUTo7mHdLo0y0NA-386G28pznaPtPeTj1GWlFLD-Ewjzb7MFWdTehoyrO7p75Y0D7sQsyL_PsdOp92dF-sc0SbCziESA8xpFxuq-Nr8mKwY8I363lKfn6--HH-pbr6dvn1_Oyq6mvguZLIQDcaBlvDUHNRS6tUI5jmKLAH55zgTA9KQ2ud6zrkqCzUerBKCwEMTkl19E13eJg7c4h-X7YzwXqzPt2WCY1kUkgo_If_8p_8rzMT4o2ZZyPaVvG24O-PeFnvz1wyNXufehxHO2FJ2XDdykbr0kVB5RHtSxIp4vDkzZlZSjaPJZulZLOWXHTv1i_mbo_uSfXYKjwASTikMw</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Kilander, Carl</creator><creator>Mattsson, Fredrik</creator><creator>Lu, Yunxia</creator><creator>Ljung, Rickard</creator><creator>Lagergren, Jesper</creator><creator>Sadr-Azodi, Omid</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>20160101</creationdate><title>Exogenous estrogen and the risk of biliary tract cancer - a population-based study in a cohort of Swedish men treated for prostate cancer</title><author>Kilander, Carl ; Mattsson, Fredrik ; Lu, Yunxia ; Ljung, Rickard ; Lagergren, Jesper ; Sadr-Azodi, Omid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-5e037873fa43f41245a6682071e2ec3ddd2107f6739addbbe1e6a347fa6722303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - therapy</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biliary Tract Neoplasms - chemically induced</topic><topic>Biliary Tract Neoplasms - epidemiology</topic><topic>Biliary Tract Neoplasms - etiology</topic><topic>Cohort Studies</topic><topic>Estrogens - adverse effects</topic><topic>Estrogens - therapeutic use</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sweden - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kilander, Carl</creatorcontrib><creatorcontrib>Mattsson, Fredrik</creatorcontrib><creatorcontrib>Lu, Yunxia</creatorcontrib><creatorcontrib>Ljung, Rickard</creatorcontrib><creatorcontrib>Lagergren, Jesper</creatorcontrib><creatorcontrib>Sadr-Azodi, Omid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kilander, Carl</au><au>Mattsson, Fredrik</au><au>Lu, Yunxia</au><au>Ljung, Rickard</au><au>Lagergren, Jesper</au><au>Sadr-Azodi, Omid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exogenous estrogen and the risk of biliary tract cancer - a population-based study in a cohort of Swedish men treated for prostate cancer</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>55</volume><issue>7</issue><spage>846</spage><epage>850</epage><pages>846-850</pages><issn>0284-186X</issn><issn>1651-226X</issn><eissn>1651-226X</eissn><abstract>To assess the role of exogenous estrogen in the etiology of biliary tract cancer, a nationwide population-based cohort study in Sweden was performed.
The study included all men in Sweden with prostate cancer diagnosed in 1961-2008. Due to treatment standards, patients diagnosed in 1961-1980 were considered more exposed to estrogen, while those diagnosed in 1981-2008 were regarded less exposed. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated to estimate the risk of biliary tract cancer in cohort members compared to the corresponding Swedish male population.
After 849 307 person-years of follow-up in 203 131 prostate cancer patients, there were 41 incident gallbladder cancers and 36 cancers of the extra-hepatic bile ducts. In overall, there were no apparent differences in the risk of gallbladder cancer or bile duct cancer between patients diagnosed in 1961-1980 and patients diagnosed in 1981-2008. However, in patients diagnosed in 1961-1980, there was a statistically non-significant increased risk of gallbladder cancer (SIR 1.34; 95% CI 0.71-2.29) and extra-hepatic bile duct cancer (SIR 1.20; 95% CI 0.55-2.28) > 5 years of follow-up after the prostate cancer diagnosis. No such association was found for patients diagnosed in 1981-2008. Sensitivity analyses excluding prostate cancer patients exposed to potential confounding factors did not change the SIRs.
Long exposure to high doses of exogenous estrogen might increase the risk of biliary tract cancer. However, any potential excess risk of bile duct cancer resulted by prolonged exposure to high doses of exogenous estrogen seems to be small.</abstract><cop>England</cop><pmid>27173637</pmid><doi>10.3109/0284186X.2015.1131333</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta oncologica, 2016-01, Vol.55 (7), p.846-850 |
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| source | Taylor & Francis; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - therapy Aged Aged, 80 and over Biliary Tract Neoplasms - chemically induced Biliary Tract Neoplasms - epidemiology Biliary Tract Neoplasms - etiology Cohort Studies Estrogens - adverse effects Estrogens - therapeutic use Follow-Up Studies Humans Male Middle Aged Prostatic Neoplasms - drug therapy Prostatic Neoplasms - therapy Retrospective Studies Risk Factors Sweden - epidemiology |
| title | Exogenous estrogen and the risk of biliary tract cancer - a population-based study in a cohort of Swedish men treated for prostate cancer |
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