Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia

Abstract Introduction Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three common forms of dementia: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's d...

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Veröffentlicht in:	Alzheimer's & dementia 2016-11, Vol.12 (11), p.1149-1158
Hauptverfasser:	Bereczki, Erika, Francis, Paul T, Howlett, David, Pereira, Joana B, Höglund, Kina, Bogstedt, Anna, Cedazo-Minguez, Angel, Baek, Jean-Ha, Hortobágyi, Tibor, Attems, Johannes, Ballard, Clive, Aarsland, Dag
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Biomarkers - metabolism Brain - metabolism Brain - pathology Cognitive Dysfunction - diagnosis Cognitive Dysfunction - etiology Cognitive Dysfunction - metabolism Cognitive Dysfunction - pathology Cognitive impairment Cohort Studies Dementia with Lewy bodies Diagnosis, Differential Disease Progression Enzyme-Linked Immunosorbent Assay Female Humans Immunoblotting Immunohistochemistry Lewy Body Disease - diagnosis Lewy Body Disease - metabolism Lewy Body Disease - pathology Lewy Body Disease - psychology Male Mental Status and Dementia Tests Multivariate Analysis Nerve Tissue Proteins - metabolism Neurogranin Neurology Parkinson's disease with dementia Rab3A Sensitivity and Specificity SNAP25 Synapses - metabolism Synaptic dysfunction
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