Proteogenomics connects somatic mutations to signalling in breast cancer

Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood. Here we describe quantitative mass-spectrometry-based proteomic and phosphoproteomic analyses of 105 genomically annotated breast...

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Veröffentlicht in:	Nature (London) 2016-06, Vol.534 (7605), p.55-62
Hauptverfasser:	Mertins, Philipp, Mani, D. R., Ruggles, Kelly V., Gillette, Michael A., Clauser, Karl R., Wang, Pei, Wang, Xianlong, Qiao, Jana W., Cao, Song, Petralia, Francesca, Kawaler, Emily, Mundt, Filip, Krug, Karsten, Tu, Zhidong, Lei, Jonathan T., Gatza, Michael L., Wilkerson, Matthew, Perou, Charles M., Yellapantula, Venkata, Huang, Kuan-lin, Lin, Chenwei, McLellan, Michael D., Yan, Ping, Davies, Sherri R., Townsend, R. Reid, Skates, Steven J., Wang, Jing, Zhang, Bing, Kinsinger, Christopher R., Mesri, Mehdi, Rodriguez, Henry, Ding, Li, Paulovich, Amanda G., Fenyö, David, Ellis, Matthew J., Carr, Steven A.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/91 45/23 631/1647/2067 631/67/1347 82/1 82/58 82/80 82/81 96/95 Analysis Breast cancer Breast Neoplasms - classification Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - metabolism Calcium-Binding Proteins - deficiency Calcium-Binding Proteins - genetics Cancer Cancer research Chromosome Deletion Chromosomes, Human, Pair 5 - genetics Class I Phosphatidylinositol 3-Kinases Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Deoxyribonucleic acid DNA Female Focal Adhesion Kinase 1 - genetics Focal Adhesion Kinase 1 - metabolism Gene amplification Gene Expression Regulation, Neoplastic Gene mutation Genetic aspects Genetic research Genomes Genomics Humanities and Social Sciences Humans Kinases Mass Spectrometry Methods Molecular Sequence Annotation multidisciplinary Mutation Mutation - genetics Oncology, Experimental p21-Activated Kinases - genetics p21-Activated Kinases - metabolism Peptides Phosphatidylinositol 3-Kinases - genetics Phosphoproteins - analysis Phosphoproteins - genetics Phosphoproteins - metabolism Physiological aspects Protein expression Protein Kinases - genetics Protein Kinases - metabolism Proteins Proteomics Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism S-Phase Kinase-Associated Proteins - genetics S-Phase Kinase-Associated Proteins - metabolism Science Signal Transduction Signaling peptides and proteins Spectrometry src-Family Kinases - genetics src-Family Kinases - metabolism Tumor Suppressor Protein p53 - genetics Tumors
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