Induction of the 5S RNP–Mdm2–p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia

Mutations resulting in constitutive activation of signaling pathways that regulate ribosome biogenesis are among the most common genetic events in acute myeloid leukemia (AML). However, whether ribosome biogenesis presents as a therapeutic target to treat AML remains unexplored. Perturbations in rib...

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Veröffentlicht in:	Leukemia 2017-01, Vol.31 (1), p.213-221
Hauptverfasser:	Jaako, P, Ugale, A, Wahlestedt, M, Velasco-Hernandez, T, Cammenga, J, Lindström, M S, Bryder, D
Format:	Artikel
Sprache:	eng
Schlagworte:	38/89 631/67/1990/283/1897 64/60 Acute myelocytic leukemia Acute myeloid leukemia Animals Apoptosis Biosynthesis Bone marrow Cancer Research Care and treatment Cell cycle Cellular signal transduction Clinical Medicine Critical Care Medicine Development and progression Evolution Gene expression Gene mutation Genes Genetic aspects Health aspects Hematologi Hematology Intensive Internal Medicine Kinases Klinisk medicin Leukemia Leukemia, Myeloid, Acute - etiology Lymphoma MDM2 protein Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicine & Public Health Mice Mutation Myc protein Oncology original-article p53 Protein Perturbation Proteins Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Proto-Oncogene Proteins c-mdm2 - physiology Ribonucleic acid Ribonucleoproteins - metabolism Ribonucleoproteins - physiology Ribosomal Proteins - deficiency Ribosomes - metabolism Ribosomes - physiology RNA RNA polymerase Signal Transduction - physiology Stem cells Stress Stress, Physiological Therapeutic targets Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology Yeast
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