Control of the innate immune response by the mevalonate pathway

Deficiency in mevalonate kinase causes autoinflammatory disease. Wang and colleagues define the detailed mechanistic basis that leads to this disease phenotype in mice and humans. Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalo...

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Veröffentlicht in:NATURE IMMUNOLOGY 2016-08, Vol.17 (8), p.922-929
Hauptverfasser: Akula, Murali K, Shi, Man, Jiang, Zhaozhao, Foster, Celia E, Miao, David, Li, Annie S, Zhang, Xiaoman, Gavin, Ruth M, Forde, Sorcha D, Germain, Gail, Carpenter, Susan, Rosadini, Charles V, Gritsman, Kira, Chae, Jae Jin, Hampton, Randolph, Silverman, Neal, Gravallese, Ellen M, Kagan, Jonathan C, Fitzgerald, Katherine A, Kastner, Daniel L, Golenbock, Douglas T, Bergo, Martin O, Wang, Donghai
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Sprache:eng
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