Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors

Type I interferons (IFNs), including IFN-α, upregulate an array of IFN-stimulated genes (ISGs) and potently suppress Human immunodeficiency virus type 1 (HIV-1) infectivity in CD4(+) T cells, monocyte-derived macrophages, and dendritic cells. Recently, we and others identified ISG myxovirus resistan...

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Veröffentlicht in:	Journal of virology 2016-08, Vol.90 (16), p.7469-7480
Hauptverfasser:	Bulli, Lorenzo, Apolonia, Luis, Kutzner, Juliane, Pollpeter, Darja, Goujon, Caroline, Herold, Nikolas, Schwarz, Sarah-Marie, Giernat, Yannick, Keppler, Oliver T, Malim, Michael H, Schaller, Torsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - metabolism Cell Line HIV Core Protein p24 - genetics HIV Core Protein p24 - metabolism HIV-1 - immunology HIV-1 - physiology Host-Pathogen Interactions Human immunodeficiency virus 1 Humans Immunity, Innate Immunologic Factors - metabolism Interferon-alpha - immunology Lentivirus Monocytes - virology Mutant Proteins - genetics Mutant Proteins - metabolism Retroviridae Virus-Cell Interactions
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