EAACI Molecular Allergology User's Guide
The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled ‘component‐resolved diagnosis’ (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User...
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| Veröffentlicht in: | Pediatric allergy and immunology 2016-05, Vol.27 (S23), p.1-250 |
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| creator | Matricardi, P. M. Kleine-Tebbe, J. Hoffmann, H. J. Valenta, R. Hilger, C. Hofmaier, S. Aalberse, R. C. Agache, I. Asero, R. Ballmer-Weber, B. Barber, D. Beyer, K. Biedermann, T. Bilò, M. B. Blank, S. Bohle, B. Bosshard, P. P. Breiteneder, H. Brough, H. A. Caraballo, L. Caubet, J. C. Crameri, R. Davies, J. M. Douladiris, N. Ebisawa, M. EIgenmann, P. A. Fernandez-Rivas, M. Ferreira, F. Gadermaier, G. Glatz, M. Hamilton, R. G. Hawranek, T. Hellings, P. Hoffmann-Sommergruber, K. Jakob, T. Jappe, U. Jutel, M. Kamath, S. D. Knol, E. F. Korosec, P. Kuehn, A. Lack, G. Lopata, A. L. Mäkelä, M. Morisset, M. Niederberger, V. Nowak-Węgrzyn, A. H. Papadopoulos, N. G. Pastorello, E. A. Pauli, G. Platts-Mills, T. Posa, D. Poulsen, L. K. Raulf, M. Sastre, J. Scala, E. Schmid, J. M. Schmid-Grendelmeier, P. van Hage, M. van Ree, R. Vieths, S. Weber, R. Wickman, M. Muraro, A. Ollert, M. |
| description | The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled ‘component‐resolved diagnosis’ (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low‐abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross‐reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE‐mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross‐reactive panallergens from plant (lipid transfer proteins, polcalcins, PR‐10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE‐mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients. |
| doi_str_mv | 10.1111/pai.12563 |
| format | Article |
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M. ; Kleine-Tebbe, J. ; Hoffmann, H. J. ; Valenta, R. ; Hilger, C. ; Hofmaier, S. ; Aalberse, R. C. ; Agache, I. ; Asero, R. ; Ballmer-Weber, B. ; Barber, D. ; Beyer, K. ; Biedermann, T. ; Bilò, M. B. ; Blank, S. ; Bohle, B. ; Bosshard, P. P. ; Breiteneder, H. ; Brough, H. A. ; Caraballo, L. ; Caubet, J. C. ; Crameri, R. ; Davies, J. M. ; Douladiris, N. ; Ebisawa, M. ; EIgenmann, P. A. ; Fernandez-Rivas, M. ; Ferreira, F. ; Gadermaier, G. ; Glatz, M. ; Hamilton, R. G. ; Hawranek, T. ; Hellings, P. ; Hoffmann-Sommergruber, K. ; Jakob, T. ; Jappe, U. ; Jutel, M. ; Kamath, S. D. ; Knol, E. F. ; Korosec, P. ; Kuehn, A. ; Lack, G. ; Lopata, A. L. ; Mäkelä, M. ; Morisset, M. ; Niederberger, V. ; Nowak-Węgrzyn, A. H. ; Papadopoulos, N. G. ; Pastorello, E. A. ; Pauli, G. ; Platts-Mills, T. ; Posa, D. ; Poulsen, L. K. ; Raulf, M. ; Sastre, J. ; Scala, E. ; Schmid, J. M. ; Schmid-Grendelmeier, P. ; van Hage, M. ; van Ree, R. ; Vieths, S. ; Weber, R. ; Wickman, M. ; Muraro, A. ; Ollert, M.</creator><creatorcontrib>Matricardi, P. M. ; Kleine-Tebbe, J. ; Hoffmann, H. J. ; Valenta, R. ; Hilger, C. ; Hofmaier, S. ; Aalberse, R. C. ; Agache, I. ; Asero, R. ; Ballmer-Weber, B. ; Barber, D. ; Beyer, K. ; Biedermann, T. ; Bilò, M. B. ; Blank, S. ; Bohle, B. ; Bosshard, P. P. ; Breiteneder, H. ; Brough, H. A. ; Caraballo, L. ; Caubet, J. C. ; Crameri, R. ; Davies, J. M. ; Douladiris, N. ; Ebisawa, M. ; EIgenmann, P. A. ; Fernandez-Rivas, M. ; Ferreira, F. ; Gadermaier, G. ; Glatz, M. ; Hamilton, R. G. ; Hawranek, T. ; Hellings, P. ; Hoffmann-Sommergruber, K. ; Jakob, T. ; Jappe, U. ; Jutel, M. ; Kamath, S. D. ; Knol, E. F. ; Korosec, P. ; Kuehn, A. ; Lack, G. ; Lopata, A. L. ; Mäkelä, M. ; Morisset, M. ; Niederberger, V. ; Nowak-Węgrzyn, A. H. ; Papadopoulos, N. G. ; Pastorello, E. A. ; Pauli, G. ; Platts-Mills, T. ; Posa, D. ; Poulsen, L. K. ; Raulf, M. ; Sastre, J. ; Scala, E. ; Schmid, J. M. ; Schmid-Grendelmeier, P. ; van Hage, M. ; van Ree, R. ; Vieths, S. ; Weber, R. ; Wickman, M. ; Muraro, A. ; Ollert, M.</creatorcontrib><description>The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled ‘component‐resolved diagnosis’ (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low‐abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross‐reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE‐mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross‐reactive panallergens from plant (lipid transfer proteins, polcalcins, PR‐10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE‐mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/pai.12563</identifier><identifier>PMID: 27288833</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Allergens - immunology ; Allergies ; allergy ; allergy diagnosis ; anaphylaxis ; asthma ; atopic dermatitis ; Biomarkers - metabolism ; component-resolved diagnosis ; diagnosis ; diagnostic algorithms ; food allergy ; guidelines ; Humans ; Hypersensitivity, Immediate - diagnosis ; Hypersensitivity, Immediate - immunology ; Hypersensitivity, Immediate - metabolism ; Hypersensitivity, Immediate - therapy ; IgE ; IgE cross-reactivity ; Immunoglobulin E - metabolism ; Immunologic Tests - methods ; lipocalins ; microarray ; molecular allergology ; non-specific lipid transfer proteins ; panallergens ; parvalbumins ; pathogenesis-related protein family 10 ; polcalcins ; precision medicine ; Precision Medicine - methods ; profilins ; serum albumins ; tropomyosins</subject><ispartof>Pediatric allergy and immunology, 2016-05, Vol.27 (S23), p.1-250</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5303-58a8a6fc5e8e34dc81e0aa030184cac75e39c79510bc6154f6264f0c2ec2cb13</citedby><cites>FETCH-LOGICAL-c5303-58a8a6fc5e8e34dc81e0aa030184cac75e39c79510bc6154f6264f0c2ec2cb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpai.12563$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpai.12563$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27288833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:134839352$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Matricardi, P. M.</creatorcontrib><creatorcontrib>Kleine-Tebbe, J.</creatorcontrib><creatorcontrib>Hoffmann, H. J.</creatorcontrib><creatorcontrib>Valenta, R.</creatorcontrib><creatorcontrib>Hilger, C.</creatorcontrib><creatorcontrib>Hofmaier, S.</creatorcontrib><creatorcontrib>Aalberse, R. C.</creatorcontrib><creatorcontrib>Agache, I.</creatorcontrib><creatorcontrib>Asero, R.</creatorcontrib><creatorcontrib>Ballmer-Weber, B.</creatorcontrib><creatorcontrib>Barber, D.</creatorcontrib><creatorcontrib>Beyer, K.</creatorcontrib><creatorcontrib>Biedermann, T.</creatorcontrib><creatorcontrib>Bilò, M. B.</creatorcontrib><creatorcontrib>Blank, S.</creatorcontrib><creatorcontrib>Bohle, B.</creatorcontrib><creatorcontrib>Bosshard, P. P.</creatorcontrib><creatorcontrib>Breiteneder, H.</creatorcontrib><creatorcontrib>Brough, H. A.</creatorcontrib><creatorcontrib>Caraballo, L.</creatorcontrib><creatorcontrib>Caubet, J. C.</creatorcontrib><creatorcontrib>Crameri, R.</creatorcontrib><creatorcontrib>Davies, J. M.</creatorcontrib><creatorcontrib>Douladiris, N.</creatorcontrib><creatorcontrib>Ebisawa, M.</creatorcontrib><creatorcontrib>EIgenmann, P. A.</creatorcontrib><creatorcontrib>Fernandez-Rivas, M.</creatorcontrib><creatorcontrib>Ferreira, F.</creatorcontrib><creatorcontrib>Gadermaier, G.</creatorcontrib><creatorcontrib>Glatz, M.</creatorcontrib><creatorcontrib>Hamilton, R. G.</creatorcontrib><creatorcontrib>Hawranek, T.</creatorcontrib><creatorcontrib>Hellings, P.</creatorcontrib><creatorcontrib>Hoffmann-Sommergruber, K.</creatorcontrib><creatorcontrib>Jakob, T.</creatorcontrib><creatorcontrib>Jappe, U.</creatorcontrib><creatorcontrib>Jutel, M.</creatorcontrib><creatorcontrib>Kamath, S. D.</creatorcontrib><creatorcontrib>Knol, E. F.</creatorcontrib><creatorcontrib>Korosec, P.</creatorcontrib><creatorcontrib>Kuehn, A.</creatorcontrib><creatorcontrib>Lack, G.</creatorcontrib><creatorcontrib>Lopata, A. L.</creatorcontrib><creatorcontrib>Mäkelä, M.</creatorcontrib><creatorcontrib>Morisset, M.</creatorcontrib><creatorcontrib>Niederberger, V.</creatorcontrib><creatorcontrib>Nowak-Węgrzyn, A. H.</creatorcontrib><creatorcontrib>Papadopoulos, N. G.</creatorcontrib><creatorcontrib>Pastorello, E. A.</creatorcontrib><creatorcontrib>Pauli, G.</creatorcontrib><creatorcontrib>Platts-Mills, T.</creatorcontrib><creatorcontrib>Posa, D.</creatorcontrib><creatorcontrib>Poulsen, L. K.</creatorcontrib><creatorcontrib>Raulf, M.</creatorcontrib><creatorcontrib>Sastre, J.</creatorcontrib><creatorcontrib>Scala, E.</creatorcontrib><creatorcontrib>Schmid, J. M.</creatorcontrib><creatorcontrib>Schmid-Grendelmeier, P.</creatorcontrib><creatorcontrib>van Hage, M.</creatorcontrib><creatorcontrib>van Ree, R.</creatorcontrib><creatorcontrib>Vieths, S.</creatorcontrib><creatorcontrib>Weber, R.</creatorcontrib><creatorcontrib>Wickman, M.</creatorcontrib><creatorcontrib>Muraro, A.</creatorcontrib><creatorcontrib>Ollert, M.</creatorcontrib><title>EAACI Molecular Allergology User's Guide</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled ‘component‐resolved diagnosis’ (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low‐abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross‐reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE‐mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross‐reactive panallergens from plant (lipid transfer proteins, polcalcins, PR‐10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE‐mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.</description><subject>Allergens - immunology</subject><subject>Allergies</subject><subject>allergy</subject><subject>allergy diagnosis</subject><subject>anaphylaxis</subject><subject>asthma</subject><subject>atopic dermatitis</subject><subject>Biomarkers - metabolism</subject><subject>component-resolved diagnosis</subject><subject>diagnosis</subject><subject>diagnostic algorithms</subject><subject>food allergy</subject><subject>guidelines</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - diagnosis</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Hypersensitivity, Immediate - metabolism</subject><subject>Hypersensitivity, Immediate - therapy</subject><subject>IgE</subject><subject>IgE cross-reactivity</subject><subject>Immunoglobulin E - metabolism</subject><subject>Immunologic Tests - methods</subject><subject>lipocalins</subject><subject>microarray</subject><subject>molecular allergology</subject><subject>non-specific lipid transfer proteins</subject><subject>panallergens</subject><subject>parvalbumins</subject><subject>pathogenesis-related protein family 10</subject><subject>polcalcins</subject><subject>precision medicine</subject><subject>Precision Medicine - methods</subject><subject>profilins</subject><subject>serum albumins</subject><subject>tropomyosins</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kE9PwjAYhxujUUQPfgFD4kE9DNt1_bPjQhCJoh40JlyaUt6ZSWHYuiDf3soGBxN7adM8_fX3PgidEdwlYd0sddElMeN0D7UITdOIYir3UQunmEWcMHGEjr3_wJgIyskhOopFLKWktIWu-lnWG3ZGpQVTWe06mbXg3ktbvq87rx7cpe8MqmIKJ-gg19bDabO30ctt_6V3Fz08DYa97CEyLPwaMaml5rlhIIEmUyMJYK0xxUQmRhvBgKZGpIzgiQnNkpzHPMmxicHEZkJoG0V1rF_BspqopSvm2q1VqQvVXM3CCRTDCRNx4K9qfunKzwr8l5oX3oC1egFl5RURKeeSJxv04g_6UVZuEYb5pRgPbhIRqOuaMq703kG-q0Cw-rWtgm21sR3Y8yaxmsxhuiO3egNwUwOrwsL6_yT1nA23kc38hf-C790L7WYqFBRMvT0OFO2NYzm-p2pEfwDWaZUN</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Matricardi, P. 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M.</creator><creator>Schmid-Grendelmeier, P.</creator><creator>van Hage, M.</creator><creator>van Ree, R.</creator><creator>Vieths, S.</creator><creator>Weber, R.</creator><creator>Wickman, M.</creator><creator>Muraro, A.</creator><creator>Ollert, M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>201605</creationdate><title>EAACI Molecular Allergology User's Guide</title><author>Matricardi, P. M. ; Kleine-Tebbe, J. ; Hoffmann, H. J. ; Valenta, R. ; Hilger, C. ; Hofmaier, S. ; Aalberse, R. C. ; Agache, I. ; Asero, R. ; Ballmer-Weber, B. ; Barber, D. ; Beyer, K. ; Biedermann, T. ; Bilò, M. B. ; Blank, S. ; Bohle, B. ; Bosshard, P. P. ; Breiteneder, H. ; Brough, H. A. ; Caraballo, L. ; Caubet, J. C. ; Crameri, R. ; Davies, J. M. ; Douladiris, N. ; Ebisawa, M. ; EIgenmann, P. A. ; Fernandez-Rivas, M. ; Ferreira, F. ; Gadermaier, G. ; Glatz, M. ; Hamilton, R. G. ; Hawranek, T. ; Hellings, P. ; Hoffmann-Sommergruber, K. ; Jakob, T. ; Jappe, U. ; Jutel, M. ; Kamath, S. D. ; Knol, E. F. ; Korosec, P. ; Kuehn, A. ; Lack, G. ; Lopata, A. L. ; Mäkelä, M. ; Morisset, M. ; Niederberger, V. ; Nowak-Węgrzyn, A. H. ; Papadopoulos, N. G. ; Pastorello, E. A. ; Pauli, G. ; Platts-Mills, T. ; Posa, D. ; Poulsen, L. K. ; Raulf, M. ; Sastre, J. ; Scala, E. ; Schmid, J. M. ; Schmid-Grendelmeier, P. ; van Hage, M. ; van Ree, R. ; Vieths, S. ; Weber, R. ; Wickman, M. ; Muraro, A. ; Ollert, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5303-58a8a6fc5e8e34dc81e0aa030184cac75e39c79510bc6154f6264f0c2ec2cb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Allergens - immunology</topic><topic>Allergies</topic><topic>allergy</topic><topic>allergy diagnosis</topic><topic>anaphylaxis</topic><topic>asthma</topic><topic>atopic dermatitis</topic><topic>Biomarkers - metabolism</topic><topic>component-resolved diagnosis</topic><topic>diagnosis</topic><topic>diagnostic algorithms</topic><topic>food allergy</topic><topic>guidelines</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - diagnosis</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Hypersensitivity, Immediate - metabolism</topic><topic>Hypersensitivity, Immediate - therapy</topic><topic>IgE</topic><topic>IgE cross-reactivity</topic><topic>Immunoglobulin E - metabolism</topic><topic>Immunologic Tests - methods</topic><topic>lipocalins</topic><topic>microarray</topic><topic>molecular allergology</topic><topic>non-specific lipid transfer proteins</topic><topic>panallergens</topic><topic>parvalbumins</topic><topic>pathogenesis-related protein family 10</topic><topic>polcalcins</topic><topic>precision medicine</topic><topic>Precision Medicine - methods</topic><topic>profilins</topic><topic>serum albumins</topic><topic>tropomyosins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matricardi, P. M.</creatorcontrib><creatorcontrib>Kleine-Tebbe, J.</creatorcontrib><creatorcontrib>Hoffmann, H. J.</creatorcontrib><creatorcontrib>Valenta, R.</creatorcontrib><creatorcontrib>Hilger, C.</creatorcontrib><creatorcontrib>Hofmaier, S.</creatorcontrib><creatorcontrib>Aalberse, R. C.</creatorcontrib><creatorcontrib>Agache, I.</creatorcontrib><creatorcontrib>Asero, R.</creatorcontrib><creatorcontrib>Ballmer-Weber, B.</creatorcontrib><creatorcontrib>Barber, D.</creatorcontrib><creatorcontrib>Beyer, K.</creatorcontrib><creatorcontrib>Biedermann, T.</creatorcontrib><creatorcontrib>Bilò, M. B.</creatorcontrib><creatorcontrib>Blank, S.</creatorcontrib><creatorcontrib>Bohle, B.</creatorcontrib><creatorcontrib>Bosshard, P. P.</creatorcontrib><creatorcontrib>Breiteneder, H.</creatorcontrib><creatorcontrib>Brough, H. A.</creatorcontrib><creatorcontrib>Caraballo, L.</creatorcontrib><creatorcontrib>Caubet, J. C.</creatorcontrib><creatorcontrib>Crameri, R.</creatorcontrib><creatorcontrib>Davies, J. M.</creatorcontrib><creatorcontrib>Douladiris, N.</creatorcontrib><creatorcontrib>Ebisawa, M.</creatorcontrib><creatorcontrib>EIgenmann, P. A.</creatorcontrib><creatorcontrib>Fernandez-Rivas, M.</creatorcontrib><creatorcontrib>Ferreira, F.</creatorcontrib><creatorcontrib>Gadermaier, G.</creatorcontrib><creatorcontrib>Glatz, M.</creatorcontrib><creatorcontrib>Hamilton, R. G.</creatorcontrib><creatorcontrib>Hawranek, T.</creatorcontrib><creatorcontrib>Hellings, P.</creatorcontrib><creatorcontrib>Hoffmann-Sommergruber, K.</creatorcontrib><creatorcontrib>Jakob, T.</creatorcontrib><creatorcontrib>Jappe, U.</creatorcontrib><creatorcontrib>Jutel, M.</creatorcontrib><creatorcontrib>Kamath, S. D.</creatorcontrib><creatorcontrib>Knol, E. F.</creatorcontrib><creatorcontrib>Korosec, P.</creatorcontrib><creatorcontrib>Kuehn, A.</creatorcontrib><creatorcontrib>Lack, G.</creatorcontrib><creatorcontrib>Lopata, A. L.</creatorcontrib><creatorcontrib>Mäkelä, M.</creatorcontrib><creatorcontrib>Morisset, M.</creatorcontrib><creatorcontrib>Niederberger, V.</creatorcontrib><creatorcontrib>Nowak-Węgrzyn, A. H.</creatorcontrib><creatorcontrib>Papadopoulos, N. G.</creatorcontrib><creatorcontrib>Pastorello, E. A.</creatorcontrib><creatorcontrib>Pauli, G.</creatorcontrib><creatorcontrib>Platts-Mills, T.</creatorcontrib><creatorcontrib>Posa, D.</creatorcontrib><creatorcontrib>Poulsen, L. K.</creatorcontrib><creatorcontrib>Raulf, M.</creatorcontrib><creatorcontrib>Sastre, J.</creatorcontrib><creatorcontrib>Scala, E.</creatorcontrib><creatorcontrib>Schmid, J. M.</creatorcontrib><creatorcontrib>Schmid-Grendelmeier, P.</creatorcontrib><creatorcontrib>van Hage, M.</creatorcontrib><creatorcontrib>van Ree, R.</creatorcontrib><creatorcontrib>Vieths, S.</creatorcontrib><creatorcontrib>Weber, R.</creatorcontrib><creatorcontrib>Wickman, M.</creatorcontrib><creatorcontrib>Muraro, A.</creatorcontrib><creatorcontrib>Ollert, M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matricardi, P. M.</au><au>Kleine-Tebbe, J.</au><au>Hoffmann, H. J.</au><au>Valenta, R.</au><au>Hilger, C.</au><au>Hofmaier, S.</au><au>Aalberse, R. C.</au><au>Agache, I.</au><au>Asero, R.</au><au>Ballmer-Weber, B.</au><au>Barber, D.</au><au>Beyer, K.</au><au>Biedermann, T.</au><au>Bilò, M. B.</au><au>Blank, S.</au><au>Bohle, B.</au><au>Bosshard, P. P.</au><au>Breiteneder, H.</au><au>Brough, H. A.</au><au>Caraballo, L.</au><au>Caubet, J. C.</au><au>Crameri, R.</au><au>Davies, J. M.</au><au>Douladiris, N.</au><au>Ebisawa, M.</au><au>EIgenmann, P. A.</au><au>Fernandez-Rivas, M.</au><au>Ferreira, F.</au><au>Gadermaier, G.</au><au>Glatz, M.</au><au>Hamilton, R. G.</au><au>Hawranek, T.</au><au>Hellings, P.</au><au>Hoffmann-Sommergruber, K.</au><au>Jakob, T.</au><au>Jappe, U.</au><au>Jutel, M.</au><au>Kamath, S. D.</au><au>Knol, E. F.</au><au>Korosec, P.</au><au>Kuehn, A.</au><au>Lack, G.</au><au>Lopata, A. L.</au><au>Mäkelä, M.</au><au>Morisset, M.</au><au>Niederberger, V.</au><au>Nowak-Węgrzyn, A. H.</au><au>Papadopoulos, N. G.</au><au>Pastorello, E. A.</au><au>Pauli, G.</au><au>Platts-Mills, T.</au><au>Posa, D.</au><au>Poulsen, L. K.</au><au>Raulf, M.</au><au>Sastre, J.</au><au>Scala, E.</au><au>Schmid, J. M.</au><au>Schmid-Grendelmeier, P.</au><au>van Hage, M.</au><au>van Ree, R.</au><au>Vieths, S.</au><au>Weber, R.</au><au>Wickman, M.</au><au>Muraro, A.</au><au>Ollert, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EAACI Molecular Allergology User's Guide</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2016-05</date><risdate>2016</risdate><volume>27</volume><issue>S23</issue><spage>1</spage><epage>250</epage><pages>1-250</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled ‘component‐resolved diagnosis’ (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low‐abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross‐reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE‐mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross‐reactive panallergens from plant (lipid transfer proteins, polcalcins, PR‐10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE‐mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27288833</pmid><doi>10.1111/pai.12563</doi><tpages>250</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0905-6157 |
| ispartof | Pediatric allergy and immunology, 2016-05, Vol.27 (S23), p.1-250 |
| issn | 0905-6157 1399-3038 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_504572 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online |
| subjects | Allergens - immunology Allergies allergy allergy diagnosis anaphylaxis asthma atopic dermatitis Biomarkers - metabolism component-resolved diagnosis diagnosis diagnostic algorithms food allergy guidelines Humans Hypersensitivity, Immediate - diagnosis Hypersensitivity, Immediate - immunology Hypersensitivity, Immediate - metabolism Hypersensitivity, Immediate - therapy IgE IgE cross-reactivity Immunoglobulin E - metabolism Immunologic Tests - methods lipocalins microarray molecular allergology non-specific lipid transfer proteins panallergens parvalbumins pathogenesis-related protein family 10 polcalcins precision medicine Precision Medicine - methods profilins serum albumins tropomyosins |
| title | EAACI Molecular Allergology User's Guide |
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