Effects of acute spinalization on neurons of postural networks
Postural limb reflexes (PLRs) represent a substantial component of postural corrections. Spinalization results in loss of postural functions, including disappearance of PLRs. The aim of the present study was to characterize the effects of acute spinalization on two populations of spinal neurons (F a...
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| Veröffentlicht in: | Scientific reports 2016-06, Vol.6 (1), p.27372-27372, Article 27372 |
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| creator | Zelenin, Pavel V. Lyalka, Vladimir F. Hsu, Li-Ju Orlovsky, Grigori N. Deliagina, Tatiana G. |
| description | Postural limb reflexes (PLRs) represent a substantial component of postural corrections. Spinalization results in loss of postural functions, including disappearance of PLRs. The aim of the present study was to characterize the effects of acute spinalization on two populations of spinal neurons (F and E) mediating PLRs, which we characterized previously. For this purpose, in decerebrate rabbits spinalized at T12, responses of interneurons from L5 to stimulation causing PLRs before spinalization, were recorded. The results were compared to control data obtained in our previous study. We found that spinalization affected the distribution of F- and E-neurons across the spinal grey matter, caused a significant decrease in their activity, as well as disturbances in processing of posture-related sensory inputs. A two-fold decrease in the proportion of F-neurons in the intermediate grey matter was observed. Location of populations of F- and E-neurons exhibiting significant decrease in their activity was determined. A dramatic decrease of the efficacy of sensory input from the ipsilateral limb to F-neurons and from the contralateral limb to E-neurons was found. These changes in operation of postural networks underlie the loss of postural control after spinalization and represent a starting point for the development of spasticity. |
| doi_str_mv | 10.1038/srep27372 |
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Spinalization results in loss of postural functions, including disappearance of PLRs. The aim of the present study was to characterize the effects of acute spinalization on two populations of spinal neurons (F and E) mediating PLRs, which we characterized previously. For this purpose, in decerebrate rabbits spinalized at T12, responses of interneurons from L5 to stimulation causing PLRs before spinalization, were recorded. The results were compared to control data obtained in our previous study. We found that spinalization affected the distribution of F- and E-neurons across the spinal grey matter, caused a significant decrease in their activity, as well as disturbances in processing of posture-related sensory inputs. A two-fold decrease in the proportion of F-neurons in the intermediate grey matter was observed. Location of populations of F- and E-neurons exhibiting significant decrease in their activity was determined. A dramatic decrease of the efficacy of sensory input from the ipsilateral limb to F-neurons and from the contralateral limb to E-neurons was found. These changes in operation of postural networks underlie the loss of postural control after spinalization and represent a starting point for the development of spasticity.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep27372</identifier><identifier>PMID: 27302149</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/2632/1823 ; 631/378/3920 ; Animals ; Extremities - physiology ; Gray Matter - physiology ; Humanities and Social Sciences ; Interneurons - physiology ; Medicin och hälsovetenskap ; multidisciplinary ; Neurons ; Neurons - physiology ; Postural Balance - physiology ; Posture ; Posture - physiology ; Rabbits ; Reflex - physiology ; Science ; Spinal cord ; Spinal Cord - physiology ; Spinal Cord Injuries - physiopathology</subject><ispartof>Scientific reports, 2016-06, Vol.6 (1), p.27372-27372, Article 27372</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Jun 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-994a03f029e9aeb130d5c41447dfc6d8602178438d654f11fdc5c3734de22a2e3</citedby><cites>FETCH-LOGICAL-c526t-994a03f029e9aeb130d5c41447dfc6d8602178438d654f11fdc5c3734de22a2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908393/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908393/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27302149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:134335354$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Zelenin, Pavel V.</creatorcontrib><creatorcontrib>Lyalka, Vladimir F.</creatorcontrib><creatorcontrib>Hsu, Li-Ju</creatorcontrib><creatorcontrib>Orlovsky, Grigori N.</creatorcontrib><creatorcontrib>Deliagina, Tatiana G.</creatorcontrib><title>Effects of acute spinalization on neurons of postural networks</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Postural limb reflexes (PLRs) represent a substantial component of postural corrections. Spinalization results in loss of postural functions, including disappearance of PLRs. The aim of the present study was to characterize the effects of acute spinalization on two populations of spinal neurons (F and E) mediating PLRs, which we characterized previously. For this purpose, in decerebrate rabbits spinalized at T12, responses of interneurons from L5 to stimulation causing PLRs before spinalization, were recorded. The results were compared to control data obtained in our previous study. We found that spinalization affected the distribution of F- and E-neurons across the spinal grey matter, caused a significant decrease in their activity, as well as disturbances in processing of posture-related sensory inputs. A two-fold decrease in the proportion of F-neurons in the intermediate grey matter was observed. Location of populations of F- and E-neurons exhibiting significant decrease in their activity was determined. A dramatic decrease of the efficacy of sensory input from the ipsilateral limb to F-neurons and from the contralateral limb to E-neurons was found. These changes in operation of postural networks underlie the loss of postural control after spinalization and represent a starting point for the development of spasticity.</description><subject>631/378/2632/1823</subject><subject>631/378/3920</subject><subject>Animals</subject><subject>Extremities - physiology</subject><subject>Gray Matter - physiology</subject><subject>Humanities and Social Sciences</subject><subject>Interneurons - physiology</subject><subject>Medicin och hälsovetenskap</subject><subject>multidisciplinary</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Postural Balance - physiology</subject><subject>Posture</subject><subject>Posture - physiology</subject><subject>Rabbits</subject><subject>Reflex - physiology</subject><subject>Science</subject><subject>Spinal cord</subject><subject>Spinal Cord - physiology</subject><subject>Spinal Cord Injuries - physiopathology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>D8T</sourceid><recordid>eNp1kk1LJDEQhsOirOJ68A_IgBcVejefnc5FEPELBC_rOcR0xW3t6bRJt6K_3tIZZ0fFEEhReepNVaUI2WL0N6Oi-pMT9FwLzX-QdU6lKrjgfGXJXiObOd9SXIobycxPsoY85UyadXJwHAL4IU9imDg_DjDJfdO5tnl2QxO7Ce4OxhS7N6KPeRiTa9E3PMZ0l3-R1eDaDJvzc4NcnRz_PTorLi5Pz48OLwqveDkUxkhHRaDcgHFwzQStlZdMSl0HX9ZVidnoSoqqLpUMjIXaKy-0kDVw7jiIDVLMdPMj9OO17VMzdenJRtfYuesOLbAKq2YMefMt36dY_w96D2RCCqGEkhh7MItFYAq1h27Akj9KfLjpmn_2Jj5YaWgljECB3blAivcj5MFOm-yhbV0HccyWaaOV5KUyiO58Qm_jmLD_b1SlJSuVRmpvRvkUM_53WCTDqH0dArsYAmS3l7NfkO9fjsD-vDV41d1AWnryi9oLTii8hg</recordid><startdate>20160615</startdate><enddate>20160615</enddate><creator>Zelenin, Pavel V.</creator><creator>Lyalka, Vladimir F.</creator><creator>Hsu, Li-Ju</creator><creator>Orlovsky, Grigori N.</creator><creator>Deliagina, Tatiana G.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20160615</creationdate><title>Effects of acute spinalization on neurons of postural networks</title><author>Zelenin, Pavel V. ; Lyalka, Vladimir F. ; Hsu, Li-Ju ; Orlovsky, Grigori N. ; Deliagina, Tatiana G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-994a03f029e9aeb130d5c41447dfc6d8602178438d654f11fdc5c3734de22a2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/378/2632/1823</topic><topic>631/378/3920</topic><topic>Animals</topic><topic>Extremities - physiology</topic><topic>Gray Matter - physiology</topic><topic>Humanities and Social Sciences</topic><topic>Interneurons - physiology</topic><topic>Medicin och hälsovetenskap</topic><topic>multidisciplinary</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Postural Balance - physiology</topic><topic>Posture</topic><topic>Posture - physiology</topic><topic>Rabbits</topic><topic>Reflex - physiology</topic><topic>Science</topic><topic>Spinal cord</topic><topic>Spinal Cord - physiology</topic><topic>Spinal Cord Injuries - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zelenin, Pavel V.</creatorcontrib><creatorcontrib>Lyalka, Vladimir F.</creatorcontrib><creatorcontrib>Hsu, Li-Ju</creatorcontrib><creatorcontrib>Orlovsky, Grigori N.</creatorcontrib><creatorcontrib>Deliagina, Tatiana G.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zelenin, Pavel V.</au><au>Lyalka, Vladimir F.</au><au>Hsu, Li-Ju</au><au>Orlovsky, Grigori N.</au><au>Deliagina, Tatiana G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of acute spinalization on neurons of postural networks</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-06-15</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>27372</spage><epage>27372</epage><pages>27372-27372</pages><artnum>27372</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Postural limb reflexes (PLRs) represent a substantial component of postural corrections. Spinalization results in loss of postural functions, including disappearance of PLRs. The aim of the present study was to characterize the effects of acute spinalization on two populations of spinal neurons (F and E) mediating PLRs, which we characterized previously. For this purpose, in decerebrate rabbits spinalized at T12, responses of interneurons from L5 to stimulation causing PLRs before spinalization, were recorded. The results were compared to control data obtained in our previous study. We found that spinalization affected the distribution of F- and E-neurons across the spinal grey matter, caused a significant decrease in their activity, as well as disturbances in processing of posture-related sensory inputs. A two-fold decrease in the proportion of F-neurons in the intermediate grey matter was observed. Location of populations of F- and E-neurons exhibiting significant decrease in their activity was determined. A dramatic decrease of the efficacy of sensory input from the ipsilateral limb to F-neurons and from the contralateral limb to E-neurons was found. These changes in operation of postural networks underlie the loss of postural control after spinalization and represent a starting point for the development of spasticity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27302149</pmid><doi>10.1038/srep27372</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378/2632/1823 631/378/3920 Animals Extremities - physiology Gray Matter - physiology Humanities and Social Sciences Interneurons - physiology Medicin och hälsovetenskap multidisciplinary Neurons Neurons - physiology Postural Balance - physiology Posture Posture - physiology Rabbits Reflex - physiology Science Spinal cord Spinal Cord - physiology Spinal Cord Injuries - physiopathology |
| title | Effects of acute spinalization on neurons of postural networks |
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