Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings
To assess the risk of psychiatric disorders in Ehlers-Danlos syndrome (EDS) and hypermobility syndrome. Nationwide population-based matched cohort study. EDS, hypermobility syndrome and psychiatric disorders were identified through Swedish national registries. Individuals with EDS (n = 1,771) were m...
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| creator | Cederlöf, Martin Larsson, Henrik Lichtenstein, Paul Almqvist, Catarina Serlachius, Eva Ludvigsson, Jonas F |
| description | To assess the risk of psychiatric disorders in Ehlers-Danlos syndrome (EDS) and hypermobility syndrome.
Nationwide population-based matched cohort study. EDS, hypermobility syndrome and psychiatric disorders were identified through Swedish national registries. Individuals with EDS (n = 1,771) were matched with comparison individuals (n = 17,710). Further, siblings to individuals with EDS who did not have an EDS diagnosis themselves were compared with matched comparison siblings. Using conditional logistic regression, risk of autism spectrum disorder (ASD), bipolar disorder, attention deficit hyperactivity disorder (ADHD), depression, attempted suicide, suicide and schizophrenia were estimated. The same analyses were conducted in individuals with hypermobility syndrome (n = 10,019) and their siblings.
EDS was associated with ASD: risk ratio (RR) 7.4, 95 % confidence interval (95 % CI) 5.2-10.7; bipolar disorder: RR 2.7, CI 1.5-4.7; ADHD: RR 5.6, CI 4.2-7.4; depression: RR 3.4, 95 % CI 2.9-4.1; and attempted suicide: RR 2.1, 95 % CI 1.7-2.7, but not with suicide or schizophrenia. EDS siblings were at increased risk of ADHD: RR 2.1, 95 % CI 1.4-3.3; depression: RR 1.5, 95 % CI 1.1-1.8; and suicide attempt: RR 1.8, 95 % CI 1.4-2.3. Similar results were observed for individuals with hypermobility syndrome and their siblings.
Individuals with EDS and hypermobility syndrome are at increased risks of being diagnosed with psychiatric disorders. These risk increases may have a genetic and/or early environmental background as suggested by evidence showing that siblings to patients have elevated risks of certain psychiatric disorders. |
| doi_str_mv | 10.1186/s12888-016-0922-6 |
| format | Article |
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Nationwide population-based matched cohort study. EDS, hypermobility syndrome and psychiatric disorders were identified through Swedish national registries. Individuals with EDS (n = 1,771) were matched with comparison individuals (n = 17,710). Further, siblings to individuals with EDS who did not have an EDS diagnosis themselves were compared with matched comparison siblings. Using conditional logistic regression, risk of autism spectrum disorder (ASD), bipolar disorder, attention deficit hyperactivity disorder (ADHD), depression, attempted suicide, suicide and schizophrenia were estimated. The same analyses were conducted in individuals with hypermobility syndrome (n = 10,019) and their siblings.
EDS was associated with ASD: risk ratio (RR) 7.4, 95 % confidence interval (95 % CI) 5.2-10.7; bipolar disorder: RR 2.7, CI 1.5-4.7; ADHD: RR 5.6, CI 4.2-7.4; depression: RR 3.4, 95 % CI 2.9-4.1; and attempted suicide: RR 2.1, 95 % CI 1.7-2.7, but not with suicide or schizophrenia. EDS siblings were at increased risk of ADHD: RR 2.1, 95 % CI 1.4-3.3; depression: RR 1.5, 95 % CI 1.1-1.8; and suicide attempt: RR 1.8, 95 % CI 1.4-2.3. Similar results were observed for individuals with hypermobility syndrome and their siblings.
Individuals with EDS and hypermobility syndrome are at increased risks of being diagnosed with psychiatric disorders. These risk increases may have a genetic and/or early environmental background as suggested by evidence showing that siblings to patients have elevated risks of certain psychiatric disorders.</description><identifier>ISSN: 1471-244X</identifier><identifier>EISSN: 1471-244X</identifier><identifier>DOI: 10.1186/s12888-016-0922-6</identifier><identifier>PMID: 27377649</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Aged, 80 and over ; Anxiety ; Autism ; Behavior disorders ; Bipolar disorder ; Care and treatment ; Child & adolescent psychiatry ; Cohort Studies ; Cohort study ; Comorbidity ; Confidence intervals ; Connective tissues ; Consent ; Diagnosis ; Ehlers-Danlos syndrome ; Ehlers-Danlos Syndrome - diagnosis ; Ehlers-Danlos Syndrome - epidemiology ; Epidemiology ; Ethics ; Female ; Genetic aspects ; Health aspects ; Health risk assessment ; Humans ; Hypermobility syndrome ; Joint Instability - epidemiology ; Logistic Models ; Male ; Mental Disorders - epidemiology ; Mental illness ; Middle Aged ; Odds Ratio ; Patients ; Physical therapy ; Physiological aspects ; Psychiatric disorders ; Psychiatry ; Psykiatri ; Registries ; Risk factors ; Schizophrenia ; Siblings ; Siblings - psychology ; Studies ; Suicides & suicide attempts ; Sweden - epidemiology ; Syndrome ; Therapeutics, Physiological</subject><ispartof>BMC PSYCHIATRY, 2016-07, Vol.16 (1), p.207-207, Article 207</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-6e1f9eecbe887a4cb0bff31de292a55213f7cccf03d9a976c82b2dd5ea400a153</citedby><cites>FETCH-LOGICAL-c530t-6e1f9eecbe887a4cb0bff31de292a55213f7cccf03d9a976c82b2dd5ea400a153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932739/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932739/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27377649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51459$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:133855559$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Cederlöf, Martin</creatorcontrib><creatorcontrib>Larsson, Henrik</creatorcontrib><creatorcontrib>Lichtenstein, Paul</creatorcontrib><creatorcontrib>Almqvist, Catarina</creatorcontrib><creatorcontrib>Serlachius, Eva</creatorcontrib><creatorcontrib>Ludvigsson, Jonas F</creatorcontrib><title>Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings</title><title>BMC PSYCHIATRY</title><addtitle>BMC Psychiatry</addtitle><description>To assess the risk of psychiatric disorders in Ehlers-Danlos syndrome (EDS) and hypermobility syndrome.
Nationwide population-based matched cohort study. EDS, hypermobility syndrome and psychiatric disorders were identified through Swedish national registries. Individuals with EDS (n = 1,771) were matched with comparison individuals (n = 17,710). Further, siblings to individuals with EDS who did not have an EDS diagnosis themselves were compared with matched comparison siblings. Using conditional logistic regression, risk of autism spectrum disorder (ASD), bipolar disorder, attention deficit hyperactivity disorder (ADHD), depression, attempted suicide, suicide and schizophrenia were estimated. The same analyses were conducted in individuals with hypermobility syndrome (n = 10,019) and their siblings.
EDS was associated with ASD: risk ratio (RR) 7.4, 95 % confidence interval (95 % CI) 5.2-10.7; bipolar disorder: RR 2.7, CI 1.5-4.7; ADHD: RR 5.6, CI 4.2-7.4; depression: RR 3.4, 95 % CI 2.9-4.1; and attempted suicide: RR 2.1, 95 % CI 1.7-2.7, but not with suicide or schizophrenia. EDS siblings were at increased risk of ADHD: RR 2.1, 95 % CI 1.4-3.3; depression: RR 1.5, 95 % CI 1.1-1.8; and suicide attempt: RR 1.8, 95 % CI 1.4-2.3. Similar results were observed for individuals with hypermobility syndrome and their siblings.
Individuals with EDS and hypermobility syndrome are at increased risks of being diagnosed with psychiatric disorders. These risk increases may have a genetic and/or early environmental background as suggested by evidence showing that siblings to patients have elevated risks of certain psychiatric disorders.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anxiety</subject><subject>Autism</subject><subject>Behavior disorders</subject><subject>Bipolar disorder</subject><subject>Care and treatment</subject><subject>Child & adolescent psychiatry</subject><subject>Cohort Studies</subject><subject>Cohort study</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Connective tissues</subject><subject>Consent</subject><subject>Diagnosis</subject><subject>Ehlers-Danlos syndrome</subject><subject>Ehlers-Danlos Syndrome - diagnosis</subject><subject>Ehlers-Danlos Syndrome - epidemiology</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypermobility syndrome</subject><subject>Joint Instability - epidemiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental illness</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Patients</subject><subject>Physical therapy</subject><subject>Physiological aspects</subject><subject>Psychiatric disorders</subject><subject>Psychiatry</subject><subject>Psykiatri</subject><subject>Registries</subject><subject>Risk factors</subject><subject>Schizophrenia</subject><subject>Siblings</subject><subject>Siblings - psychology</subject><subject>Studies</subject><subject>Suicides & suicide attempts</subject><subject>Sweden - epidemiology</subject><subject>Syndrome</subject><subject>Therapeutics, Physiological</subject><issn>1471-244X</issn><issn>1471-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNp1kstu1DAUhiMEoqXwAGyQJTYsCNiOndgbpFFbLlIFG0DsLMc-mbhk7NROOsqj8LZ4mKEXJGRbvpzv_L79RfGc4DeEiPptIlQIUWJSl1hSWtYPimPCGlJSxn48vDM-Kp6kdIkxaQQnj4sj2lRNUzN5XPz6rCcX_NZZQGMY5-HPtGx1AotM6EOcUJpmu6DQoTEtpnd6is4g61KIFmJCzudq3bWzsx4S2rqpR-f9kEPlmfZDSCgt3sawARQi6pcR4ia0bnDTchvR3qKpBxdRcu3g_Do9LR51WQ-eHfqT4tv786-nH8uLLx8-na4uSsMrPJU1kE4CmBaEaDQzLW67riIWqKSac0qqrjHGdLiyUsumNoK21FoOmmGsCa9OinKvm7Ywzq0ao9vouKignTos_cwjUBwz3LDMv_4vf-a-r1SI69xmxQnjMuPv9nhmN2AN-Cnq4V7W_Yh3vVqHa8Vklb9pJ_DqIBDD1QxpUhuXDAyD9hDmpIjAtGEEc5HRl_-gl2GOPr9epjjOhVX8llrrAZTzXcj7mp2oWrFaUsGk3GmRPWViSClCd3NkgtXOfWrvPpXdp3buU3XOeXH3rjcZf-1W_QYaLdvY</recordid><startdate>20160704</startdate><enddate>20160704</enddate><creator>Cederlöf, Martin</creator><creator>Larsson, Henrik</creator><creator>Lichtenstein, Paul</creator><creator>Almqvist, Catarina</creator><creator>Serlachius, Eva</creator><creator>Ludvigsson, Jonas F</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>AABEP</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D91</scope><scope>ZZAVC</scope></search><sort><creationdate>20160704</creationdate><title>Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings</title><author>Cederlöf, Martin ; Larsson, Henrik ; Lichtenstein, Paul ; Almqvist, Catarina ; Serlachius, Eva ; Ludvigsson, Jonas F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-6e1f9eecbe887a4cb0bff31de292a55213f7cccf03d9a976c82b2dd5ea400a153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anxiety</topic><topic>Autism</topic><topic>Behavior disorders</topic><topic>Bipolar disorder</topic><topic>Care and treatment</topic><topic>Child & adolescent psychiatry</topic><topic>Cohort Studies</topic><topic>Cohort study</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Connective tissues</topic><topic>Consent</topic><topic>Diagnosis</topic><topic>Ehlers-Danlos syndrome</topic><topic>Ehlers-Danlos Syndrome - diagnosis</topic><topic>Ehlers-Danlos Syndrome - epidemiology</topic><topic>Epidemiology</topic><topic>Ethics</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hypermobility syndrome</topic><topic>Joint Instability - epidemiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Mental Disorders - epidemiology</topic><topic>Mental illness</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Patients</topic><topic>Physical therapy</topic><topic>Physiological aspects</topic><topic>Psychiatric disorders</topic><topic>Psychiatry</topic><topic>Psykiatri</topic><topic>Registries</topic><topic>Risk factors</topic><topic>Schizophrenia</topic><topic>Siblings</topic><topic>Siblings - psychology</topic><topic>Studies</topic><topic>Suicides & suicide attempts</topic><topic>Sweden - epidemiology</topic><topic>Syndrome</topic><topic>Therapeutics, Physiological</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cederlöf, Martin</creatorcontrib><creatorcontrib>Larsson, Henrik</creatorcontrib><creatorcontrib>Lichtenstein, Paul</creatorcontrib><creatorcontrib>Almqvist, Catarina</creatorcontrib><creatorcontrib>Serlachius, Eva</creatorcontrib><creatorcontrib>Ludvigsson, Jonas F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Örebro universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Örebro universitet</collection><collection>SwePub Articles full text</collection><jtitle>BMC PSYCHIATRY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cederlöf, Martin</au><au>Larsson, Henrik</au><au>Lichtenstein, Paul</au><au>Almqvist, Catarina</au><au>Serlachius, Eva</au><au>Ludvigsson, Jonas F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings</atitle><jtitle>BMC PSYCHIATRY</jtitle><addtitle>BMC Psychiatry</addtitle><date>2016-07-04</date><risdate>2016</risdate><volume>16</volume><issue>1</issue><spage>207</spage><epage>207</epage><pages>207-207</pages><artnum>207</artnum><issn>1471-244X</issn><eissn>1471-244X</eissn><abstract>To assess the risk of psychiatric disorders in Ehlers-Danlos syndrome (EDS) and hypermobility syndrome.
Nationwide population-based matched cohort study. EDS, hypermobility syndrome and psychiatric disorders were identified through Swedish national registries. Individuals with EDS (n = 1,771) were matched with comparison individuals (n = 17,710). Further, siblings to individuals with EDS who did not have an EDS diagnosis themselves were compared with matched comparison siblings. Using conditional logistic regression, risk of autism spectrum disorder (ASD), bipolar disorder, attention deficit hyperactivity disorder (ADHD), depression, attempted suicide, suicide and schizophrenia were estimated. The same analyses were conducted in individuals with hypermobility syndrome (n = 10,019) and their siblings.
EDS was associated with ASD: risk ratio (RR) 7.4, 95 % confidence interval (95 % CI) 5.2-10.7; bipolar disorder: RR 2.7, CI 1.5-4.7; ADHD: RR 5.6, CI 4.2-7.4; depression: RR 3.4, 95 % CI 2.9-4.1; and attempted suicide: RR 2.1, 95 % CI 1.7-2.7, but not with suicide or schizophrenia. EDS siblings were at increased risk of ADHD: RR 2.1, 95 % CI 1.4-3.3; depression: RR 1.5, 95 % CI 1.1-1.8; and suicide attempt: RR 1.8, 95 % CI 1.4-2.3. Similar results were observed for individuals with hypermobility syndrome and their siblings.
Individuals with EDS and hypermobility syndrome are at increased risks of being diagnosed with psychiatric disorders. These risk increases may have a genetic and/or early environmental background as suggested by evidence showing that siblings to patients have elevated risks of certain psychiatric disorders.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27377649</pmid><doi>10.1186/s12888-016-0922-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Aged Aged, 80 and over Anxiety Autism Behavior disorders Bipolar disorder Care and treatment Child & adolescent psychiatry Cohort Studies Cohort study Comorbidity Confidence intervals Connective tissues Consent Diagnosis Ehlers-Danlos syndrome Ehlers-Danlos Syndrome - diagnosis Ehlers-Danlos Syndrome - epidemiology Epidemiology Ethics Female Genetic aspects Health aspects Health risk assessment Humans Hypermobility syndrome Joint Instability - epidemiology Logistic Models Male Mental Disorders - epidemiology Mental illness Middle Aged Odds Ratio Patients Physical therapy Physiological aspects Psychiatric disorders Psychiatry Psykiatri Registries Risk factors Schizophrenia Siblings Siblings - psychology Studies Suicides & suicide attempts Sweden - epidemiology Syndrome Therapeutics, Physiological |
| title | Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings |
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