Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus

Objectives: The development of microvascular complications in diabetes is a complex process in which endothelial dysfunction is important. Emerging evidence suggests that arginase is a key mediator of endothelial dysfunction in type 2 diabetes mellitus by reciprocally regulating nitric oxide bioavai...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2016-11, Vol.101 (11), p.3952-3958
Hauptverfasser:	Kövamees, Oskar, Shemyakin, Alexey, Checa, Antonio, Wheelock, Craig E, Lundberg, Jon O, Östenson, Claes-Göran, Pernow, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Aged Arginase - antagonists & inhibitors Arginase - metabolism Arginine - adverse effects Arginine - analogs & derivatives Arginine - therapeutic use Cardiovascular Agents - adverse effects Cardiovascular Agents - therapeutic use Diabetes Mellitus, Type 2 - complications Diabetic Angiopathies - blood Diabetic Angiopathies - drug therapy Diabetic Angiopathies - metabolism Diabetic Angiopathies - physiopathology Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Enzyme Inhibitors - adverse effects Enzyme Inhibitors - therapeutic use Female Humans Laser-Doppler Flowmetry Male Microvessels - drug effects Microvessels - physiopathology Middle Aged Nitroprusside - pharmacology Ornithine - blood Peripheral Vascular Diseases - complications Peripheral Vascular Diseases - drug therapy Peripheral Vascular Diseases - metabolism Peripheral Vascular Diseases - physiopathology Severity of Illness Index Vascular Resistance - drug effects Vasodilation - drug effects Vasodilator Agents - pharmacology
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