Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons

The LIM-homeodomain transcription factors Lmx1a and Lmx1b play critical roles during the development of midbrain dopaminergic progenitors, but their functions in the adult brain remain poorly understood. We show here that sustained expression of Lmx1a and Lmx1b is required for the survival of adult...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-07, Vol.113 (30), p.E4387-E4396
Hauptverfasser:	Doucet-Beaupré, Hélène, Gilbert, Catherine, Profes, Marcos Schaan, Chabrat, Audrey, Pacelli, Consiglia, Giguère, Nicolas, Rioux, Véronique, Charest, Julien, Deng, Qiaolin, Laguna, Ariadna, Ericson, Johan, Perlmann, Thomas, Ang, Siew-Lan, Cicchetti, Francesca, Parent, Martin, Trudeau, Louis-Eric, Lévesque, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Animals Biological Sciences Cell Survival - genetics Developmental stages DNA Damage Dopamine Dopaminergic Neurons - metabolism Gene Expression Regulation, Developmental HEK293 Cells Humans Inactivation LIM-Homeodomain Proteins - deficiency LIM-Homeodomain Proteins - genetics Medicin och hälsovetenskap Mesencephalon - metabolism Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Neurons Oxidative Stress Parkinson's disease PNAS Plus Protein Aggregation, Pathological Transcription Factors - deficiency Transcription Factors - genetics
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