Expression of sex steroid hormone receptors in human skeletal muscle during the menstrual cycle
Aim Variations in sex hormone levels during the menstrual cycle may affect neuromuscular performance and the risk of sustaining musculoskeletal injury in women. The aim of this study was to investigate mRNA and protein levels for sex steroid hormone receptors in skeletal muscle in three distinct pha...
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| Veröffentlicht in: | Acta Physiologica 2017-02, Vol.219 (2), p.486-493 |
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| creator | Ekenros, L. Papoutsi, Z. Fridén, C. Dahlman Wright, K. Lindén Hirschberg, A. |
| description | Aim
Variations in sex hormone levels during the menstrual cycle may affect neuromuscular performance and the risk of sustaining musculoskeletal injury in women. The aim of this study was to investigate mRNA and protein levels for sex steroid hormone receptors in skeletal muscle in three distinct phases of the menstrual cycle.
Methods
Fifteen, healthy women with regular menstrual cycles participated in the study. Muscle biopsies from the vastus lateralis were obtained in three hormonally verified phases of the menstrual cycle for each individual, that is the follicular phase, the ovulatory phase and the luteal phase. mRNA and protein levels of oestrogen (ERα and ERβ), progesterone (PR) and androgen (AR) receptors were analysed.
Results
There was an overall significant variation in mRNA and protein levels of ERα and PR across the menstrual cycle. mRNA and protein levels of ERα were highest in the follicular phase when oestradiol levels were low, whereas protein levels of PR were highest in the luteal phase when progesterone levels were high. mRNA levels of PR were highest in the ovulatory phase. No significant variation in AR levels was detected across the menstrual cycle. ERβ levels were very low in all three phases of the menstrual cycle.
Conclusion
Significant variations in mRNA and protein levels of ERα and PR were detected in skeletal muscle during three confirmed phases of the menstrual cycle. These results may have an impact on effects of muscular training and sports injuries in women. |
| doi_str_mv | 10.1111/apha.12757 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_503708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4309435341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5317-c09e81795936c0ad8528a37523c138465ee5a3d57caaaa379aca375dc3485b143</originalsourceid><addsrcrecordid>eNqN0kFrFDEUB_Agii21Fz-ABLyIODUvmUwyx6WtrVDQg3oN2czb7rQzkzGZ0O63N9NZ9yAo5pKQ9-NPeHmEvAZ2Bnl9tOPWngFXUj0jx6BKXYCC6vnhzPQROY3xjjEGHETJ-UtyxFUptNb1MTGXj2PAGFs_UL-hER9pnDD4tqFbH3o_IA3ocJx8iLQd6Db1dqDxHjucbEf7FF2HtEmhHW7ptEXa4xCnkHLN7XLpFXmxsV3E0_1-Qr5_uvx2fl3cfLn6fL66KZwUoArHatSgalmLyjHbaMm1FUpy4UDospKI0opGKmfzEqq2bi43TpRarqEUJ6RYcuMDjmltxtD2NuyMt63ZX93nExrJRO5J9h_-6i_aHyvjw61JyQiogfHM3y18DP5nwjiZvo0Ou84O6FM0oCstOFRc_wflleKaCZHp2z_onU9hyH2aAzlXtapm9X5RLvgYA24OjwVm5hkw8wyYpxnI-M0-Mq17bA70949nAAt4aDvc_SPKrL5er5bQX0eUu5k</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1862279763</pqid></control><display><type>article</type><title>Expression of sex steroid hormone receptors in human skeletal muscle during the menstrual cycle</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ekenros, L. ; Papoutsi, Z. ; Fridén, C. ; Dahlman Wright, K. ; Lindén Hirschberg, A.</creator><creatorcontrib>Ekenros, L. ; Papoutsi, Z. ; Fridén, C. ; Dahlman Wright, K. ; Lindén Hirschberg, A.</creatorcontrib><description>Aim
Variations in sex hormone levels during the menstrual cycle may affect neuromuscular performance and the risk of sustaining musculoskeletal injury in women. The aim of this study was to investigate mRNA and protein levels for sex steroid hormone receptors in skeletal muscle in three distinct phases of the menstrual cycle.
Methods
Fifteen, healthy women with regular menstrual cycles participated in the study. Muscle biopsies from the vastus lateralis were obtained in three hormonally verified phases of the menstrual cycle for each individual, that is the follicular phase, the ovulatory phase and the luteal phase. mRNA and protein levels of oestrogen (ERα and ERβ), progesterone (PR) and androgen (AR) receptors were analysed.
Results
There was an overall significant variation in mRNA and protein levels of ERα and PR across the menstrual cycle. mRNA and protein levels of ERα were highest in the follicular phase when oestradiol levels were low, whereas protein levels of PR were highest in the luteal phase when progesterone levels were high. mRNA levels of PR were highest in the ovulatory phase. No significant variation in AR levels was detected across the menstrual cycle. ERβ levels were very low in all three phases of the menstrual cycle.
Conclusion
Significant variations in mRNA and protein levels of ERα and PR were detected in skeletal muscle during three confirmed phases of the menstrual cycle. These results may have an impact on effects of muscular training and sports injuries in women.</description><identifier>ISSN: 1748-1708</identifier><identifier>ISSN: 1748-1716</identifier><identifier>EISSN: 1748-1716</identifier><identifier>DOI: 10.1111/apha.12757</identifier><identifier>PMID: 27438889</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; androgen receptor ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Menstrual Cycle - physiology ; Menstruation ; Muscle, Skeletal - metabolism ; Musculoskeletal system ; oestrogen receptor-alpha ; oestrogen receptor-beta ; Polymerase Chain Reaction ; progesterone receptor ; Proteins ; Receptors, Androgen - analysis ; Receptors, Androgen - biosynthesis ; Receptors, Estrogen - analysis ; Receptors, Estrogen - biosynthesis ; Receptors, Progesterone - analysis ; Receptors, Progesterone - biosynthesis ; skeletal muscle ; Sports injuries ; Young Adult</subject><ispartof>Acta Physiologica, 2017-02, Vol.219 (2), p.486-493</ispartof><rights>2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd</rights><rights>2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5317-c09e81795936c0ad8528a37523c138465ee5a3d57caaaa379aca375dc3485b143</citedby><cites>FETCH-LOGICAL-c5317-c09e81795936c0ad8528a37523c138465ee5a3d57caaaa379aca375dc3485b143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapha.12757$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapha.12757$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27438889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-319102$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:135189731$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ekenros, L.</creatorcontrib><creatorcontrib>Papoutsi, Z.</creatorcontrib><creatorcontrib>Fridén, C.</creatorcontrib><creatorcontrib>Dahlman Wright, K.</creatorcontrib><creatorcontrib>Lindén Hirschberg, A.</creatorcontrib><title>Expression of sex steroid hormone receptors in human skeletal muscle during the menstrual cycle</title><title>Acta Physiologica</title><addtitle>Acta Physiol (Oxf)</addtitle><description>Aim
Variations in sex hormone levels during the menstrual cycle may affect neuromuscular performance and the risk of sustaining musculoskeletal injury in women. The aim of this study was to investigate mRNA and protein levels for sex steroid hormone receptors in skeletal muscle in three distinct phases of the menstrual cycle.
Methods
Fifteen, healthy women with regular menstrual cycles participated in the study. Muscle biopsies from the vastus lateralis were obtained in three hormonally verified phases of the menstrual cycle for each individual, that is the follicular phase, the ovulatory phase and the luteal phase. mRNA and protein levels of oestrogen (ERα and ERβ), progesterone (PR) and androgen (AR) receptors were analysed.
Results
There was an overall significant variation in mRNA and protein levels of ERα and PR across the menstrual cycle. mRNA and protein levels of ERα were highest in the follicular phase when oestradiol levels were low, whereas protein levels of PR were highest in the luteal phase when progesterone levels were high. mRNA levels of PR were highest in the ovulatory phase. No significant variation in AR levels was detected across the menstrual cycle. ERβ levels were very low in all three phases of the menstrual cycle.
Conclusion
Significant variations in mRNA and protein levels of ERα and PR were detected in skeletal muscle during three confirmed phases of the menstrual cycle. These results may have an impact on effects of muscular training and sports injuries in women.</description><subject>Adult</subject><subject>androgen receptor</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Menstrual Cycle - physiology</subject><subject>Menstruation</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Musculoskeletal system</subject><subject>oestrogen receptor-alpha</subject><subject>oestrogen receptor-beta</subject><subject>Polymerase Chain Reaction</subject><subject>progesterone receptor</subject><subject>Proteins</subject><subject>Receptors, Androgen - analysis</subject><subject>Receptors, Androgen - biosynthesis</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Estrogen - biosynthesis</subject><subject>Receptors, Progesterone - analysis</subject><subject>Receptors, Progesterone - biosynthesis</subject><subject>skeletal muscle</subject><subject>Sports injuries</subject><subject>Young Adult</subject><issn>1748-1708</issn><issn>1748-1716</issn><issn>1748-1716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0kFrFDEUB_Agii21Fz-ABLyIODUvmUwyx6WtrVDQg3oN2czb7rQzkzGZ0O63N9NZ9yAo5pKQ9-NPeHmEvAZ2Bnl9tOPWngFXUj0jx6BKXYCC6vnhzPQROY3xjjEGHETJ-UtyxFUptNb1MTGXj2PAGFs_UL-hER9pnDD4tqFbH3o_IA3ocJx8iLQd6Db1dqDxHjucbEf7FF2HtEmhHW7ptEXa4xCnkHLN7XLpFXmxsV3E0_1-Qr5_uvx2fl3cfLn6fL66KZwUoArHatSgalmLyjHbaMm1FUpy4UDospKI0opGKmfzEqq2bi43TpRarqEUJ6RYcuMDjmltxtD2NuyMt63ZX93nExrJRO5J9h_-6i_aHyvjw61JyQiogfHM3y18DP5nwjiZvo0Ou84O6FM0oCstOFRc_wflleKaCZHp2z_onU9hyH2aAzlXtapm9X5RLvgYA24OjwVm5hkw8wyYpxnI-M0-Mq17bA70949nAAt4aDvc_SPKrL5er5bQX0eUu5k</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Ekenros, L.</creator><creator>Papoutsi, Z.</creator><creator>Fridén, C.</creator><creator>Dahlman Wright, K.</creator><creator>Lindén Hirschberg, A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TS</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>201702</creationdate><title>Expression of sex steroid hormone receptors in human skeletal muscle during the menstrual cycle</title><author>Ekenros, L. ; Papoutsi, Z. ; Fridén, C. ; Dahlman Wright, K. ; Lindén Hirschberg, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5317-c09e81795936c0ad8528a37523c138465ee5a3d57caaaa379aca375dc3485b143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>androgen receptor</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Menstrual Cycle - physiology</topic><topic>Menstruation</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Musculoskeletal system</topic><topic>oestrogen receptor-alpha</topic><topic>oestrogen receptor-beta</topic><topic>Polymerase Chain Reaction</topic><topic>progesterone receptor</topic><topic>Proteins</topic><topic>Receptors, Androgen - analysis</topic><topic>Receptors, Androgen - biosynthesis</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Estrogen - biosynthesis</topic><topic>Receptors, Progesterone - analysis</topic><topic>Receptors, Progesterone - biosynthesis</topic><topic>skeletal muscle</topic><topic>Sports injuries</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ekenros, L.</creatorcontrib><creatorcontrib>Papoutsi, Z.</creatorcontrib><creatorcontrib>Fridén, C.</creatorcontrib><creatorcontrib>Dahlman Wright, K.</creatorcontrib><creatorcontrib>Lindén Hirschberg, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Acta Physiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ekenros, L.</au><au>Papoutsi, Z.</au><au>Fridén, C.</au><au>Dahlman Wright, K.</au><au>Lindén Hirschberg, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of sex steroid hormone receptors in human skeletal muscle during the menstrual cycle</atitle><jtitle>Acta Physiologica</jtitle><addtitle>Acta Physiol (Oxf)</addtitle><date>2017-02</date><risdate>2017</risdate><volume>219</volume><issue>2</issue><spage>486</spage><epage>493</epage><pages>486-493</pages><issn>1748-1708</issn><issn>1748-1716</issn><eissn>1748-1716</eissn><abstract>Aim
Variations in sex hormone levels during the menstrual cycle may affect neuromuscular performance and the risk of sustaining musculoskeletal injury in women. The aim of this study was to investigate mRNA and protein levels for sex steroid hormone receptors in skeletal muscle in three distinct phases of the menstrual cycle.
Methods
Fifteen, healthy women with regular menstrual cycles participated in the study. Muscle biopsies from the vastus lateralis were obtained in three hormonally verified phases of the menstrual cycle for each individual, that is the follicular phase, the ovulatory phase and the luteal phase. mRNA and protein levels of oestrogen (ERα and ERβ), progesterone (PR) and androgen (AR) receptors were analysed.
Results
There was an overall significant variation in mRNA and protein levels of ERα and PR across the menstrual cycle. mRNA and protein levels of ERα were highest in the follicular phase when oestradiol levels were low, whereas protein levels of PR were highest in the luteal phase when progesterone levels were high. mRNA levels of PR were highest in the ovulatory phase. No significant variation in AR levels was detected across the menstrual cycle. ERβ levels were very low in all three phases of the menstrual cycle.
Conclusion
Significant variations in mRNA and protein levels of ERα and PR were detected in skeletal muscle during three confirmed phases of the menstrual cycle. These results may have an impact on effects of muscular training and sports injuries in women.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27438889</pmid><doi>10.1111/apha.12757</doi><tpages>8</tpages></addata></record> |
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| ispartof | Acta Physiologica, 2017-02, Vol.219 (2), p.486-493 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult androgen receptor Enzyme-Linked Immunosorbent Assay Female Humans Menstrual Cycle - physiology Menstruation Muscle, Skeletal - metabolism Musculoskeletal system oestrogen receptor-alpha oestrogen receptor-beta Polymerase Chain Reaction progesterone receptor Proteins Receptors, Androgen - analysis Receptors, Androgen - biosynthesis Receptors, Estrogen - analysis Receptors, Estrogen - biosynthesis Receptors, Progesterone - analysis Receptors, Progesterone - biosynthesis skeletal muscle Sports injuries Young Adult |
| title | Expression of sex steroid hormone receptors in human skeletal muscle during the menstrual cycle |
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