Guidelines to PET measurements of the target occupancy in the brain for drug development
This guideline summarizes the current view of the European Association of Nuclear Medicine Drug Development Committee. The purpose of this guideline is to guarantee a high standard of PET studies that are aimed at measuring target occupancy in the brain within the framework of development programs o...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2016-11, Vol.43 (12), p.2255-2262 |
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| container_title | European journal of nuclear medicine and molecular imaging |
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| creator | Takano, Akihiro Varrone, Andrea Gulyás, Balázs Salvadori, Piero Gee, Antony Windhorst, Albert Vercouillie, Johnny Bormans, Guy Lammertsma, Adriaan A. Halldin, Christer |
| description | This guideline summarizes the current view of the European Association of Nuclear Medicine Drug Development Committee. The purpose of this guideline is to guarantee a high standard of PET studies that are aimed at measuring target occupancy in the brain within the framework of development programs of drugs that act within the central nervous system (CNS drugs). This guideline is intended to present information specifically adapted to European practice. The information provided should be applied within the context of local conditions and regulations. |
| doi_str_mv | 10.1007/s00259-016-3476-4 |
| format | Article |
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The purpose of this guideline is to guarantee a high standard of PET studies that are aimed at measuring target occupancy in the brain within the framework of development programs of drugs that act within the central nervous system (CNS drugs). This guideline is intended to present information specifically adapted to European practice. The information provided should be applied within the context of local conditions and regulations.</description><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Cardiology</subject><subject>Central Nervous System Agents - administration & dosage</subject><subject>Central Nervous System Agents - pharmacokinetics</subject><subject>Drug Design</subject><subject>Drug Monitoring - standards</subject><subject>Drug therapy</subject><subject>European Union</subject><subject>Guidelines</subject><subject>Imaging</subject><subject>Medical imaging</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Molecular Imaging - standards</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Orthopedics</subject><subject>Positron-Emission Tomography - standards</subject><subject>Practice Guidelines as Topic</subject><subject>Radiology</subject><issn>1619-7070</issn><issn>1619-7089</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>D8T</sourceid><recordid>eNqNkk9rFTEUxYMotlY_gBsJuHEzmv-ZbAQptS0UdFHBXchMbl6nzkzGZKbSb2_G9_pshYKLMJfkd86dmxyEXlPynhKiP2RCmDQVoariQqtKPEGHVFFTaVKbp_takwP0IudrQmjNavMcHTAtqZCsPkTfT5fOQ9-NkPEc8deTSzyAy0uCAcY54xjwfAV4dmkDM45tu0xubG9xN_7Zb5IrVYgJ-7RssIcb6OO0Sl-iZ8H1GV7tvkfo2-eTy-Oz6uLL6fnxp4uqVVLPlWetbBxAUCaQhtZCaEeM4lo3wgfnWwUi6IYYxgjjoJomKBcY8UXkG2X4Eaq2vvkXTEtjp9QNLt3a6Dq72_pRKrCS8DJ-4c2j_JSi_yu6E1IuuGSEy6L9uNUWYADfljGT6x9aPDgZuyu7iTelt9CG02LwbmeQ4s8F8myHLrfQ926EuGRL69KlLMn_A2XaUF0etKBv_0Gv45LGcusrJbmSql570y3VpphzgrD_b0rsGie7jZMtcbJrnKwomjf3B94r7vJTALa7zXI0biDda_2o62__N9gp</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Takano, Akihiro</creator><creator>Varrone, Andrea</creator><creator>Gulyás, Balázs</creator><creator>Salvadori, Piero</creator><creator>Gee, Antony</creator><creator>Windhorst, Albert</creator><creator>Vercouillie, Johnny</creator><creator>Bormans, Guy</creator><creator>Lammertsma, Adriaan A.</creator><creator>Halldin, Christer</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-3034-7721</orcidid></search><sort><creationdate>20161101</creationdate><title>Guidelines to PET measurements of the target occupancy in the brain for drug development</title><author>Takano, Akihiro ; Varrone, Andrea ; Gulyás, Balázs ; Salvadori, Piero ; Gee, Antony ; Windhorst, Albert ; Vercouillie, Johnny ; Bormans, Guy ; Lammertsma, Adriaan A. ; Halldin, Christer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c657t-d2c5baeef69f0b18447a096377b4dfadc6e4f7b0922023e6bbf6af20dbaedb693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Brain</topic><topic>Brain - 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| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2016-11, Vol.43 (12), p.2255-2262 |
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| language | eng |
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| subjects | Brain Brain - metabolism Cardiology Central Nervous System Agents - administration & dosage Central Nervous System Agents - pharmacokinetics Drug Design Drug Monitoring - standards Drug therapy European Union Guidelines Imaging Medical imaging Medicin och hälsovetenskap Medicine Medicine & Public Health Molecular Imaging - standards Nerve Tissue Proteins - metabolism Nuclear Medicine Oncology Orthopedics Positron-Emission Tomography - standards Practice Guidelines as Topic Radiology |
| title | Guidelines to PET measurements of the target occupancy in the brain for drug development |
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