Co-morbidity after oesophageal cancer surgery and recovery of health-related quality of life
Background Although health‐related quality of life (HRQoL) recovers after surgery for oesophageal cancer in most long‐term survivors, one in seven patients experiences a deterioration in HRQoL for reasons yet unknown. The aim of this study was to assess whether co‐morbidities diagnosed after surgery...
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| Veröffentlicht in: | British journal of surgery 2016-11, Vol.103 (12), p.1665-1675 |
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| container_title | British journal of surgery |
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| creator | Backemar, L. Wikman, A. Djärv, T. Johar, A. Lagergren, P. |
| description | Background
Although health‐related quality of life (HRQoL) recovers after surgery for oesophageal cancer in most long‐term survivors, one in seven patients experiences a deterioration in HRQoL for reasons yet unknown. The aim of this study was to assess whether co‐morbidities diagnosed after surgery influence recovery of HRQoL.
Methods
Patients who underwent surgery for cancer of the oesophagus or gastro‐oesophageal junction in Sweden between 2001 and 2005 were included. HRQoL was assessed by means of the European Organization for Research and Treatment of Cancer QLQ‐C30 and QLQ‐OES18 questionnaires. Repeated‐measures ANOVA was used to assess mean differences in HRQoL scores between three co‐morbidity status groups (healthy, stable and increased) over time. Probabilities of deterioration in HRQoL were calculated based on marginal probabilities from logistic regression models.
Results
At 5 years' follow‐up, 153 (24·8 per cent) of 616 patients were alive and 137 responded to at least two of three questionnaires. The healthy and increased co‐morbidity groups showed deterioration in almost all aspects of HRQoL at 6 months after surgery compared with baseline. The increased co‐morbidity group also deteriorated in several aspects from 3 to 5 years after surgery. Patients with an increase in co‐morbidity did not have a significantly increased probability of deterioration in HRQoL over time compared with healthy or stable patients, except with respect to cognitive function, loss of appetite, choking and coughing.
Conclusion
Patients with an increase in co‐morbidities after oesophagectomy experience long‐term deterioration in HRQoL.
Deterioration in quality of life with increasing comorbidity |
| doi_str_mv | 10.1002/bjs.10248 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_502955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1834998170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5268-6e8de89ae7dcd6cf3a3ba5d080208e682148f68faae9c3c823aa7f8975abe31f3</originalsourceid><addsrcrecordid>eNp90ktvEzEQAGALUdFQOPAH0EpcOLCtH-vHHkuAQtUCohAuSNbs7mzidBOn9i4l_x6nCamEBCePx59Hfgwhzxg9ZpTyk2oeU8AL84CMmFAy50yZh2REKdU5E1wckscxzillgkr-iBxyLQtZajMiP8Y-X_hQucb16wzaHkPmMfrVDKYIXVbDsk6pOIQphgSWTRaw9j83E99ms2T6WR6wgx6b7GaAblMnrXSuxSfkoIUu4tPdeES-vXv7dfw-v_h09mF8epHXkiuTKzQNmhJQN3Wj6laAqEA21FBODSrDWWFaZVoALGtRGy4AdGtKLaFCwVpxRPJt3XiLq6Gyq-AWENbWg7O71HWK0ErKSymTf_VP_8ZNTq0PUzsMtqBUGpb4yy1fBX8zYOztwsUauw6W6IdomRFFWRqmaaIv_qJzP4RlurzlVEgtmaTqf2pTq9BGKZHU850aqgU2-1P--bwETrbg1nW43q8zajddYVNX2LuusK_Pr-6C-4dyscdf-x0Qrq3SQkv7_eOZnVxOrsrJl8_2XPwG14y4-g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1834478663</pqid></control><display><type>article</type><title>Co-morbidity after oesophageal cancer surgery and recovery of health-related quality of life</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Backemar, L. ; Wikman, A. ; Djärv, T. ; Johar, A. ; Lagergren, P.</creator><creatorcontrib>Backemar, L. ; Wikman, A. ; Djärv, T. ; Johar, A. ; Lagergren, P.</creatorcontrib><description>Background
Although health‐related quality of life (HRQoL) recovers after surgery for oesophageal cancer in most long‐term survivors, one in seven patients experiences a deterioration in HRQoL for reasons yet unknown. The aim of this study was to assess whether co‐morbidities diagnosed after surgery influence recovery of HRQoL.
Methods
Patients who underwent surgery for cancer of the oesophagus or gastro‐oesophageal junction in Sweden between 2001 and 2005 were included. HRQoL was assessed by means of the European Organization for Research and Treatment of Cancer QLQ‐C30 and QLQ‐OES18 questionnaires. Repeated‐measures ANOVA was used to assess mean differences in HRQoL scores between three co‐morbidity status groups (healthy, stable and increased) over time. Probabilities of deterioration in HRQoL were calculated based on marginal probabilities from logistic regression models.
Results
At 5 years' follow‐up, 153 (24·8 per cent) of 616 patients were alive and 137 responded to at least two of three questionnaires. The healthy and increased co‐morbidity groups showed deterioration in almost all aspects of HRQoL at 6 months after surgery compared with baseline. The increased co‐morbidity group also deteriorated in several aspects from 3 to 5 years after surgery. Patients with an increase in co‐morbidity did not have a significantly increased probability of deterioration in HRQoL over time compared with healthy or stable patients, except with respect to cognitive function, loss of appetite, choking and coughing.
Conclusion
Patients with an increase in co‐morbidities after oesophagectomy experience long‐term deterioration in HRQoL.
Deterioration in quality of life with increasing comorbidity</description><identifier>ISSN: 0007-1323</identifier><identifier>ISSN: 1365-2168</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.10248</identifier><identifier>PMID: 27545978</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - surgery ; Adult ; Aged ; Cancer ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - surgery ; Comorbidity ; Esophageal cancer ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - surgery ; Esophagectomy - mortality ; Esophagogastric Junction - surgery ; Female ; Humans ; Male ; Middle Aged ; Morbidity ; Quality of Life ; Surgery ; Sweden - epidemiology</subject><ispartof>British journal of surgery, 2016-11, Vol.103 (12), p.1665-1675</ispartof><rights>2016 BJS Society Ltd Published by John Wiley & Sons Ltd</rights><rights>2016 BJS Society Ltd Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 BJS Society Ltd. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5268-6e8de89ae7dcd6cf3a3ba5d080208e682148f68faae9c3c823aa7f8975abe31f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.10248$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.10248$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27545978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-400581$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:134651475$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Backemar, L.</creatorcontrib><creatorcontrib>Wikman, A.</creatorcontrib><creatorcontrib>Djärv, T.</creatorcontrib><creatorcontrib>Johar, A.</creatorcontrib><creatorcontrib>Lagergren, P.</creatorcontrib><title>Co-morbidity after oesophageal cancer surgery and recovery of health-related quality of life</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background
Although health‐related quality of life (HRQoL) recovers after surgery for oesophageal cancer in most long‐term survivors, one in seven patients experiences a deterioration in HRQoL for reasons yet unknown. The aim of this study was to assess whether co‐morbidities diagnosed after surgery influence recovery of HRQoL.
Methods
Patients who underwent surgery for cancer of the oesophagus or gastro‐oesophageal junction in Sweden between 2001 and 2005 were included. HRQoL was assessed by means of the European Organization for Research and Treatment of Cancer QLQ‐C30 and QLQ‐OES18 questionnaires. Repeated‐measures ANOVA was used to assess mean differences in HRQoL scores between three co‐morbidity status groups (healthy, stable and increased) over time. Probabilities of deterioration in HRQoL were calculated based on marginal probabilities from logistic regression models.
Results
At 5 years' follow‐up, 153 (24·8 per cent) of 616 patients were alive and 137 responded to at least two of three questionnaires. The healthy and increased co‐morbidity groups showed deterioration in almost all aspects of HRQoL at 6 months after surgery compared with baseline. The increased co‐morbidity group also deteriorated in several aspects from 3 to 5 years after surgery. Patients with an increase in co‐morbidity did not have a significantly increased probability of deterioration in HRQoL over time compared with healthy or stable patients, except with respect to cognitive function, loss of appetite, choking and coughing.
Conclusion
Patients with an increase in co‐morbidities after oesophagectomy experience long‐term deterioration in HRQoL.
Deterioration in quality of life with increasing comorbidity</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Comorbidity</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy - mortality</subject><subject>Esophagogastric Junction - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Quality of Life</subject><subject>Surgery</subject><subject>Sweden - epidemiology</subject><issn>0007-1323</issn><issn>1365-2168</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90ktvEzEQAGALUdFQOPAH0EpcOLCtH-vHHkuAQtUCohAuSNbs7mzidBOn9i4l_x6nCamEBCePx59Hfgwhzxg9ZpTyk2oeU8AL84CMmFAy50yZh2REKdU5E1wckscxzillgkr-iBxyLQtZajMiP8Y-X_hQucb16wzaHkPmMfrVDKYIXVbDsk6pOIQphgSWTRaw9j83E99ms2T6WR6wgx6b7GaAblMnrXSuxSfkoIUu4tPdeES-vXv7dfw-v_h09mF8epHXkiuTKzQNmhJQN3Wj6laAqEA21FBODSrDWWFaZVoALGtRGy4AdGtKLaFCwVpxRPJt3XiLq6Gyq-AWENbWg7O71HWK0ErKSymTf_VP_8ZNTq0PUzsMtqBUGpb4yy1fBX8zYOztwsUauw6W6IdomRFFWRqmaaIv_qJzP4RlurzlVEgtmaTqf2pTq9BGKZHU850aqgU2-1P--bwETrbg1nW43q8zajddYVNX2LuusK_Pr-6C-4dyscdf-x0Qrq3SQkv7_eOZnVxOrsrJl8_2XPwG14y4-g</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Backemar, L.</creator><creator>Wikman, A.</creator><creator>Djärv, T.</creator><creator>Johar, A.</creator><creator>Lagergren, P.</creator><general>John Wiley & Sons, Ltd</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>201611</creationdate><title>Co-morbidity after oesophageal cancer surgery and recovery of health-related quality of life</title><author>Backemar, L. ; Wikman, A. ; Djärv, T. ; Johar, A. ; Lagergren, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5268-6e8de89ae7dcd6cf3a3ba5d080208e682148f68faae9c3c823aa7f8975abe31f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Comorbidity</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy - mortality</topic><topic>Esophagogastric Junction - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Quality of Life</topic><topic>Surgery</topic><topic>Sweden - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Backemar, L.</creatorcontrib><creatorcontrib>Wikman, A.</creatorcontrib><creatorcontrib>Djärv, T.</creatorcontrib><creatorcontrib>Johar, A.</creatorcontrib><creatorcontrib>Lagergren, P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Backemar, L.</au><au>Wikman, A.</au><au>Djärv, T.</au><au>Johar, A.</au><au>Lagergren, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-morbidity after oesophageal cancer surgery and recovery of health-related quality of life</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2016-11</date><risdate>2016</risdate><volume>103</volume><issue>12</issue><spage>1665</spage><epage>1675</epage><pages>1665-1675</pages><issn>0007-1323</issn><issn>1365-2168</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Background
Although health‐related quality of life (HRQoL) recovers after surgery for oesophageal cancer in most long‐term survivors, one in seven patients experiences a deterioration in HRQoL for reasons yet unknown. The aim of this study was to assess whether co‐morbidities diagnosed after surgery influence recovery of HRQoL.
Methods
Patients who underwent surgery for cancer of the oesophagus or gastro‐oesophageal junction in Sweden between 2001 and 2005 were included. HRQoL was assessed by means of the European Organization for Research and Treatment of Cancer QLQ‐C30 and QLQ‐OES18 questionnaires. Repeated‐measures ANOVA was used to assess mean differences in HRQoL scores between three co‐morbidity status groups (healthy, stable and increased) over time. Probabilities of deterioration in HRQoL were calculated based on marginal probabilities from logistic regression models.
Results
At 5 years' follow‐up, 153 (24·8 per cent) of 616 patients were alive and 137 responded to at least two of three questionnaires. The healthy and increased co‐morbidity groups showed deterioration in almost all aspects of HRQoL at 6 months after surgery compared with baseline. The increased co‐morbidity group also deteriorated in several aspects from 3 to 5 years after surgery. Patients with an increase in co‐morbidity did not have a significantly increased probability of deterioration in HRQoL over time compared with healthy or stable patients, except with respect to cognitive function, loss of appetite, choking and coughing.
Conclusion
Patients with an increase in co‐morbidities after oesophagectomy experience long‐term deterioration in HRQoL.
Deterioration in quality of life with increasing comorbidity</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>27545978</pmid><doi>10.1002/bjs.10248</doi><tpages>11</tpages></addata></record> |
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| ispartof | British journal of surgery, 2016-11, Vol.103 (12), p.1665-1675 |
| issn | 0007-1323 1365-2168 1365-2168 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adenocarcinoma - mortality Adenocarcinoma - surgery Adult Aged Cancer Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - surgery Comorbidity Esophageal cancer Esophageal Neoplasms - mortality Esophageal Neoplasms - surgery Esophagectomy - mortality Esophagogastric Junction - surgery Female Humans Male Middle Aged Morbidity Quality of Life Surgery Sweden - epidemiology |
| title | Co-morbidity after oesophageal cancer surgery and recovery of health-related quality of life |
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