Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes

To characterize the mutational patterns of acute lymphoblastic leukemia (ALL) we performed deep next generation sequencing of 872 cancer genes in 172 diagnostic and 24 relapse samples from 172 pediatric ALL patients. We found an overall greater mutational burden and more driver mutations in T-cell A...

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Veröffentlicht in:	ONCOTARGET 2016, Vol.7 (39), p.64071-64088
Hauptverfasser:	Lindqvist, C Mårten, Lundmark, Anders, Nordlund, Jessica, Freyhult, Eva, Ekman, Diana, Carlsson Almlöf, Jonas, Raine, Amanda, Övernäs, Elin, Abrahamsson, Jonas, Frost, Britt-Marie, Grandér, Dan, Heyman, Mats, Palle, Josefine, Forestier, Erik, Lönnerholm, Gudmar, Berglund, Eva C, Syvänen, Ann-Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukemia Adaptor Proteins, Signal Transducing Child Child, Preschool clonal evolution Cohort Studies DNA Mutational Analysis DNA-Binding Proteins E1A-Associated p300 Protein - genetics Epigenesis, Genetic High-Throughput Nucleotide Sequencing Humans Immunophenotyping Infant Intracellular Signaling Peptides and Proteins Mutation Neoplasm Recurrence, Local - genetics Nuclear Proteins - genetics Oncogene Proteins, Fusion - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Proteins - genetics Recurrence relapse Remission Induction Research Paper Sequence Analysis, DNA somatic mutation targeted next generation sequencing Transcription Factors - genetics Translocation, Genetic
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