Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With...

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Veröffentlicht in:	American journal of human genetics 2016-10, Vol.99 (4), p.903-911
Hauptverfasser:	French, Juliet D., Michailidou, Kyriaki, Nord, Silje, Beesley, Jonathan, Canisus, Sander, Kaufmann, Susanne, Moradi Marjaneh, Mahdi, Lee, Jason S., Dennis, Joe, Bolla, Manjeet K., Wang, Qin, Milne, Roger L., Hopper, John L., Southey, Melissa C., Schmidt, Marjanka K., Lophatananon, Artitaya, Fasching, Peter A., Beckmann, Matthias W., Fletcher, Olivia, Johnson, Nichola, Sawyer, Elinor J., Tomlinson, Ian, Burwinkel, Barbara, Marme, Frederik, Guénel, Pascal, Truong, Thérèse, Flyger, Henrik, Benitez, Javier, González-Neira, Anna, Alonso, M. Rosario, Pita, Guillermo, Neuhausen, Susan L., Anton-Culver, Hoda, Brenner, Hermann, Arndt, Volker, Schmutzler, Rita K., Brauch, Hiltrud, Hamann, Ute, Tessier, Daniel C., Vincent, Daniel, Nevanlinna, Heli, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Dörk, Thilo, Bogdanova, Natalia V., Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Wu, Anna H., Van Den Berg, David, Lambrechts, Diether, Floris, Giuseppe, Chang-Claude, Jenny, Rudolph, Anja, Barile, Monica, Couch, Fergus J., Hallberg, Emily, Giles, Graham G., Le Marchand, Loic, Goldberg, Mark S., Yip, Cheng Har, Zheng, Wei, Winqvist, Robert, Pylkäs, Katri, Andrulis, Irene L., Devilee, Peter, Tollenaar, Rob A.E.M., García-Closas, Montserrat, Figueroa, Jonine, Hall, Per, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Hooning, Maartje J., Koppert, Linetta B., Li, Jingmei, Shu, Xiao-Ou, Cox, Angela, Cross, Simon S., Kang, Daehee, Hartman, Mikael, Chia, Kee Seng, Kabisch, Maria, Torres, Diana, Luccarini, Craig, Conroy, Don M., Jakubowska, Anna, Sangrajrang, Suleeporn, Brennan, Paul, Olswold, Curtis, Slager, Susan, Shen, Chen-Yang, Hou, Ming-Feng, Swerdlow, Anthony, Schoemaker, Minouk J., Pharoah, Paul D.P., Kristensen, Vessela, Dunning, Alison M., Edwards, Stacey L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Case-Control Studies Cell Line, Tumor Chromosomes, Human, Pair 5 - genetics Enhancer Elements, Genetic - genetics Fibroblast Growth Factor 10 - genetics Fibroblast Growth Factor 10 - metabolism Gene expression Genetic Predisposition to Disease - genetics Genetics Genomes Haplotypes - genetics Humans Life Sciences Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Proteins Quantitative Trait Loci - genetics Receptor, Fibroblast Growth Factor, Type 2 - metabolism Receptors, Estrogen - metabolism
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