Gene expression elucidates functional impact of polygenic risk for schizophrenia

The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of subjects with schizophrenia ( N = 258) and control subjects ( N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, they found that ∼20% of schizophrenia loci have variants that...

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Veröffentlicht in:	Nature neuroscience 2016-11, Vol.19 (11), p.1442-1453
Hauptverfasser:	Fromer, Menachem, Roussos, Panos, Sieberts, Solveig K, Johnson, Jessica S, Kavanagh, David H, Perumal, Thanneer M, Ruderfer, Douglas M, Oh, Edwin C, Topol, Aaron, Shah, Hardik R, Klei, Lambertus L, Kramer, Robin, Pinto, Dalila, Gümüş, Zeynep H, Cicek, A Ercument, Dang, Kristen K, Browne, Andrew, Lu, Cong, Xie, Lu, Readhead, Ben, Stahl, Eli A, Xiao, Jianqiu, Parvizi, Mahsa, Hamamsy, Tymor, Fullard, John F, Wang, Ying-Chih, Mahajan, Milind C, Derry, Jonathan M J, Dudley, Joel T, Hemby, Scott E, Logsdon, Benjamin A, Talbot, Konrad, Raj, Towfique, Bennett, David A, De Jager, Philip L, Zhu, Jun, Zhang, Bin, Sullivan, Patrick F, Chess, Andrew, Purcell, Shaun M, Shinobu, Leslie A, Mangravite, Lara M, Toyoshiba, Hiroyoshi, Gur, Raquel E, Hahn, Chang-Gyu, Lewis, David A, Haroutunian, Vahram, Peters, Mette A, Lipska, Barbara K, Buxbaum, Joseph D, Schadt, Eric E, Hirai, Keisuke, Roeder, Kathryn, Brennand, Kristen J, Katsanis, Nicholas, Domenici, Enrico, Devlin, Bernie, Sklar, Pamela
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 38/22 38/39 45/100 45/43 45/91 631/208/199 631/208/212 631/378/2583 64/116 692/699/476/1799 706/648/697/129 Alzheimer's disease Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biology Biomedicine Brain - metabolism Brain research Consortia Danio rerio Disease Female Gene expression Gene Expression Regulation - genetics Gene loci Genetic aspects Genetic Predisposition to Disease Genetics Genome-Wide Association Study Genomics Health risk assessment Humans Male Medicine Mental disorders Multifactorial Inheritance - genetics Neurobiology Neurosciences Pharmaceutical industry Physiological aspects Polymorphism, Single Nucleotide Psychiatry Risk Risk factors Schizophrenia Schizophrenia - genetics
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