Molecular epidemiology and the evolution of human coxsackievirus A6
Coxsackievirus A6 (CV-A6) is a major aetiologic agent for hand, foot and mouth disease (HFMD) in recent years. HFMD outbreaks associated with CV-A6 resulted from the evolutionary dynamics of CV-A6 and the appearance of novel recombinant forms (RFs). To examine this, 151 variants collected in 2013 an...
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| Veröffentlicht in: | Journal of general virology 2016-12, Vol.97 (12), p.3225-3231 |
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| creator | Puenpa, Jiratchaya Vongpunsawad, Sompong Österback, Riikka Waris, Matti Eriksson, Eva Albert, Jan Midgley, Sofie Fischer, Thea K Eis-Hübinger, Anna M Cabrerizo, María Gaunt, Eleanor Simmonds, Peter Poovorawan, Yong |
| description | Coxsackievirus A6 (CV-A6) is a major aetiologic agent for hand, foot and mouth disease (HFMD) in recent years. HFMD outbreaks associated with CV-A6 resulted from the evolutionary dynamics of CV-A6 and the appearance of novel recombinant forms (RFs). To examine this, 151 variants collected in 2013 and 2014 from Germany, Spain, Sweden, Denmark and Thailand were genotyped for the VP1 capsid and 3Dpol genes. Analysis of the VP1 gene showed an increasing correspondence between CV-A6 genome recombination and sequence divergence (estimated substitution rate of 8.1×10-3 substitutions site-1 year-1 and RF half-life of 3.1 years). Bayesian phylogenetic analysis showed that recent recombination groups (RF-E, -F, -H, -J and -K) shared a common ancestor (RF-A). Thirty-nine full-length genomes of different RFs revealed recombination breakpoints between the 2A-2C and the 5' UTRs. The emergence of new CV-A6 recombination groups has become widespread in Europe and Asia within the last 8 years. |
| doi_str_mv | 10.1099/jgv.0.000619 |
| format | Article |
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HFMD outbreaks associated with CV-A6 resulted from the evolutionary dynamics of CV-A6 and the appearance of novel recombinant forms (RFs). To examine this, 151 variants collected in 2013 and 2014 from Germany, Spain, Sweden, Denmark and Thailand were genotyped for the VP1 capsid and 3Dpol genes. Analysis of the VP1 gene showed an increasing correspondence between CV-A6 genome recombination and sequence divergence (estimated substitution rate of 8.1×10-3 substitutions site-1 year-1 and RF half-life of 3.1 years). Bayesian phylogenetic analysis showed that recent recombination groups (RF-E, -F, -H, -J and -K) shared a common ancestor (RF-A). Thirty-nine full-length genomes of different RFs revealed recombination breakpoints between the 2A-2C and the 5' UTRs. 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HFMD outbreaks associated with CV-A6 resulted from the evolutionary dynamics of CV-A6 and the appearance of novel recombinant forms (RFs). To examine this, 151 variants collected in 2013 and 2014 from Germany, Spain, Sweden, Denmark and Thailand were genotyped for the VP1 capsid and 3Dpol genes. Analysis of the VP1 gene showed an increasing correspondence between CV-A6 genome recombination and sequence divergence (estimated substitution rate of 8.1×10-3 substitutions site-1 year-1 and RF half-life of 3.1 years). Bayesian phylogenetic analysis showed that recent recombination groups (RF-E, -F, -H, -J and -K) shared a common ancestor (RF-A). Thirty-nine full-length genomes of different RFs revealed recombination breakpoints between the 2A-2C and the 5' UTRs. The emergence of new CV-A6 recombination groups has become widespread in Europe and Asia within the last 8 years.</description><subject>Asia - epidemiology</subject><subject>Capsid Proteins - genetics</subject><subject>Enterovirus</subject><subject>Enterovirus - classification</subject><subject>Enterovirus - genetics</subject><subject>Enterovirus - isolation & purification</subject><subject>Europe</subject><subject>Evolution, Molecular</subject><subject>Genotype</subject><subject>Hand, Foot and Mouth Disease - epidemiology</subject><subject>Hand, Foot and Mouth Disease - virology</subject><subject>Humans</subject><subject>Medicin och hälsovetenskap</subject><subject>Molecular Epidemiology</subject><subject>Phylogeny</subject><subject>Picornaviridae</subject><subject>Recombination, Genetic</subject><issn>0022-1317</issn><issn>1465-2099</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNkb1PwzAQxS0EoqWwMaOMDKScv-J4rCq-pCIWmC3bcdq0SV3iptD_nlRpy4TEdKe733s63UPoGsMQg5T38-lmCEMASLA8QX3MEh6TdnGK-gCExJhi0UMXIcwBMGNcnKMeEYkkwFgfjV996WxT6jpyqyJzVeFLP91GeplF65mL3MaXzbrwy8jn0ayp9DKy_jtouyjcpqibEI2SS3SW6zK4q30doI_Hh_fxczx5e3oZjyaxZRzWscwzY0BqI7i2TBhmDEtzZkkuqTRMSyF0whl3QhibSaIhFxkzMqXMgTaYDlDc-YYvt2qMWtVFpeut8rpQ-9Gi7ZziQIDvePknv6p99is6CDFladp-ibTa207bgp-NC2tVFcG6stRL55ugcJqkFBMh2D9QyilPhZAtetehtvYh1C4_3oRB7dJUbZoKVJdmi9_snRtTuewIH-KjPxlOnBs</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Puenpa, Jiratchaya</creator><creator>Vongpunsawad, Sompong</creator><creator>Österback, Riikka</creator><creator>Waris, Matti</creator><creator>Eriksson, Eva</creator><creator>Albert, Jan</creator><creator>Midgley, Sofie</creator><creator>Fischer, Thea K</creator><creator>Eis-Hübinger, Anna M</creator><creator>Cabrerizo, María</creator><creator>Gaunt, Eleanor</creator><creator>Simmonds, Peter</creator><creator>Poovorawan, Yong</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20161201</creationdate><title>Molecular epidemiology and the evolution of human coxsackievirus A6</title><author>Puenpa, Jiratchaya ; Vongpunsawad, Sompong ; Österback, Riikka ; Waris, Matti ; Eriksson, Eva ; Albert, Jan ; Midgley, Sofie ; Fischer, Thea K ; Eis-Hübinger, Anna M ; Cabrerizo, María ; Gaunt, Eleanor ; Simmonds, Peter ; Poovorawan, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-9fdbb09ab75ac47b4bb48f4c2f939b4a977a6545e77bcd92a0f7d4b9834e0ab13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Asia - epidemiology</topic><topic>Capsid Proteins - genetics</topic><topic>Enterovirus</topic><topic>Enterovirus - classification</topic><topic>Enterovirus - genetics</topic><topic>Enterovirus - isolation & purification</topic><topic>Europe</topic><topic>Evolution, Molecular</topic><topic>Genotype</topic><topic>Hand, Foot and Mouth Disease - epidemiology</topic><topic>Hand, Foot and Mouth Disease - virology</topic><topic>Humans</topic><topic>Medicin och hälsovetenskap</topic><topic>Molecular Epidemiology</topic><topic>Phylogeny</topic><topic>Picornaviridae</topic><topic>Recombination, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puenpa, Jiratchaya</creatorcontrib><creatorcontrib>Vongpunsawad, Sompong</creatorcontrib><creatorcontrib>Österback, Riikka</creatorcontrib><creatorcontrib>Waris, Matti</creatorcontrib><creatorcontrib>Eriksson, Eva</creatorcontrib><creatorcontrib>Albert, Jan</creatorcontrib><creatorcontrib>Midgley, Sofie</creatorcontrib><creatorcontrib>Fischer, Thea K</creatorcontrib><creatorcontrib>Eis-Hübinger, Anna M</creatorcontrib><creatorcontrib>Cabrerizo, María</creatorcontrib><creatorcontrib>Gaunt, Eleanor</creatorcontrib><creatorcontrib>Simmonds, Peter</creatorcontrib><creatorcontrib>Poovorawan, Yong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puenpa, Jiratchaya</au><au>Vongpunsawad, Sompong</au><au>Österback, Riikka</au><au>Waris, Matti</au><au>Eriksson, Eva</au><au>Albert, Jan</au><au>Midgley, Sofie</au><au>Fischer, Thea K</au><au>Eis-Hübinger, Anna M</au><au>Cabrerizo, María</au><au>Gaunt, Eleanor</au><au>Simmonds, Peter</au><au>Poovorawan, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular epidemiology and the evolution of human coxsackievirus A6</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>97</volume><issue>12</issue><spage>3225</spage><epage>3231</epage><pages>3225-3231</pages><issn>0022-1317</issn><issn>1465-2099</issn><eissn>1465-2099</eissn><abstract>Coxsackievirus A6 (CV-A6) is a major aetiologic agent for hand, foot and mouth disease (HFMD) in recent years. 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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Alma/SFX Local Collection |
| subjects | Asia - epidemiology Capsid Proteins - genetics Enterovirus Enterovirus - classification Enterovirus - genetics Enterovirus - isolation & purification Europe Evolution, Molecular Genotype Hand, Foot and Mouth Disease - epidemiology Hand, Foot and Mouth Disease - virology Humans Medicin och hälsovetenskap Molecular Epidemiology Phylogeny Picornaviridae Recombination, Genetic |
| title | Molecular epidemiology and the evolution of human coxsackievirus A6 |
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