No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis
In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosom...
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| Veröffentlicht in: | Scientific reports 2016-10, Vol.6 (1), p.35278-35278, Article 35278 |
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| creator | Loley, Christina Alver, Maris Assimes, Themistocles L. Bjonnes, Andrew Goel, Anuj Gustafsson, Stefan Hernesniemi, Jussi Hopewell, Jemma C. Kanoni, Stavroula Kleber, Marcus E. Lau, King Wai Lu, Yingchang Lyytikäinen, Leo-Pekka Nelson, Christopher P. Nikpay, Majid Qu, Liming Salfati, Elias Scholz, Markus Tukiainen, Taru Willenborg, Christina Won, Hong-Hee Zeng, Lingyao Zhang, Weihua Anand, Sonia S. Beutner, Frank Bottinger, Erwin P. Clarke, Robert Dedoussis, George Do, Ron Esko, Tõnu Eskola, Markku Farrall, Martin Gauguier, Dominique Giedraitis, Vilmantas Granger, Christopher B. Hall, Alistair S. Hamsten, Anders Hazen, Stanley L. Huang, Jie Kähönen, Mika Kyriakou, Theodosios Laaksonen, Reijo Lind, Lars Lindgren, Cecilia Magnusson, Patrik K. E. Marouli, Eirini Mihailov, Evelin Morris, Andrew P. Nikus, Kjell Pedersen, Nancy Rallidis, Loukianos Salomaa, Veikko Shah, Svati H. Stewart, Alexandre F. R. Thompson, John R. Zalloua, Pierre A. Chambers, John C. Collins, Rory Ingelsson, Erik Iribarren, Carlos Karhunen, Pekka J. Kooner, Jaspal S. Lehtimäki, Terho Loos, Ruth J. F. März, Winfried McPherson, Ruth Metspalu, Andres Reilly, Muredach P. Ripatti, Samuli Sanghera, Dharambir K. Thiery, Joachim Watkins, Hugh Deloukas, Panos Kathiresan, Sekar Samani, Nilesh J. Schunkert, Heribert Erdmann, Jeanette König, Inke R. |
| description | In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the role of X-chromosomal variants in CAD. To fill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000 CAD cases and 58,000 controls from 35 international study cohorts. For quality control, sex-specific filters were used to adequately take the special structure of X-chromosomal data into account. For single study analyses, several logistic regression models were calculated allowing for inactivation of one female X-chromosome, adjusting for sex and investigating interactions between sex and genetic variants. Then, meta-analyses including all 35 studies were conducted using random effects models. None of the investigated models revealed genome-wide significant associations for any variant. Although we analyzed the largest-to-date sample, currently available methods were not able to detect any associations of X-chromosomal variants with CAD. |
| doi_str_mv | 10.1038/srep35278 |
| format | Article |
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E. ; Marouli, Eirini ; Mihailov, Evelin ; Morris, Andrew P. ; Nikus, Kjell ; Pedersen, Nancy ; Rallidis, Loukianos ; Salomaa, Veikko ; Shah, Svati H. ; Stewart, Alexandre F. R. ; Thompson, John R. ; Zalloua, Pierre A. ; Chambers, John C. ; Collins, Rory ; Ingelsson, Erik ; Iribarren, Carlos ; Karhunen, Pekka J. ; Kooner, Jaspal S. ; Lehtimäki, Terho ; Loos, Ruth J. F. ; März, Winfried ; McPherson, Ruth ; Metspalu, Andres ; Reilly, Muredach P. ; Ripatti, Samuli ; Sanghera, Dharambir K. ; Thiery, Joachim ; Watkins, Hugh ; Deloukas, Panos ; Kathiresan, Sekar ; Samani, Nilesh J. ; Schunkert, Heribert ; Erdmann, Jeanette ; König, Inke R.</creator><creatorcontrib>Loley, Christina ; Alver, Maris ; Assimes, Themistocles L. ; Bjonnes, Andrew ; Goel, Anuj ; Gustafsson, Stefan ; Hernesniemi, Jussi ; Hopewell, Jemma C. ; Kanoni, Stavroula ; Kleber, Marcus E. ; Lau, King Wai ; Lu, Yingchang ; Lyytikäinen, Leo-Pekka ; Nelson, Christopher P. ; Nikpay, Majid ; Qu, Liming ; Salfati, Elias ; Scholz, Markus ; Tukiainen, Taru ; Willenborg, Christina ; Won, Hong-Hee ; Zeng, Lingyao ; Zhang, Weihua ; Anand, Sonia S. ; Beutner, Frank ; Bottinger, Erwin P. ; Clarke, Robert ; Dedoussis, George ; Do, Ron ; Esko, Tõnu ; Eskola, Markku ; Farrall, Martin ; Gauguier, Dominique ; Giedraitis, Vilmantas ; Granger, Christopher B. ; Hall, Alistair S. ; Hamsten, Anders ; Hazen, Stanley L. ; Huang, Jie ; Kähönen, Mika ; Kyriakou, Theodosios ; Laaksonen, Reijo ; Lind, Lars ; Lindgren, Cecilia ; Magnusson, Patrik K. E. ; Marouli, Eirini ; Mihailov, Evelin ; Morris, Andrew P. ; Nikus, Kjell ; Pedersen, Nancy ; Rallidis, Loukianos ; Salomaa, Veikko ; Shah, Svati H. ; Stewart, Alexandre F. R. ; Thompson, John R. ; Zalloua, Pierre A. ; Chambers, John C. ; Collins, Rory ; Ingelsson, Erik ; Iribarren, Carlos ; Karhunen, Pekka J. ; Kooner, Jaspal S. ; Lehtimäki, Terho ; Loos, Ruth J. F. ; März, Winfried ; McPherson, Ruth ; Metspalu, Andres ; Reilly, Muredach P. ; Ripatti, Samuli ; Sanghera, Dharambir K. ; Thiery, Joachim ; Watkins, Hugh ; Deloukas, Panos ; Kathiresan, Sekar ; Samani, Nilesh J. ; Schunkert, Heribert ; Erdmann, Jeanette ; König, Inke R.</creatorcontrib><description>In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the role of X-chromosomal variants in CAD. To fill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000 CAD cases and 58,000 controls from 35 international study cohorts. For quality control, sex-specific filters were used to adequately take the special structure of X-chromosomal data into account. For single study analyses, several logistic regression models were calculated allowing for inactivation of one female X-chromosome, adjusting for sex and investigating interactions between sex and genetic variants. Then, meta-analyses including all 35 studies were conducted using random effects models. None of the investigated models revealed genome-wide significant associations for any variant. Although we analyzed the largest-to-date sample, currently available methods were not able to detect any associations of X-chromosomal variants with CAD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep35278</identifier><identifier>PMID: 27731410</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/205/2138 ; 692/4019 ; Cardiovascular disease ; Chromosomes ; Chromosomes, Human, X ; Cohort Studies ; Coronary artery ; Coronary Artery Disease - genetics ; Coronary vessels ; Female ; Females ; Filters ; Genetic variance ; Genome-wide association studies ; Genomes ; Heart diseases ; Humanities and Social Sciences ; Humans ; Inactivation ; International studies ; Internationality ; Male ; Medicin och hälsovetenskap ; Meta-analysis ; multidisciplinary ; Quality control ; Regression analysis ; Science ; Sex ; Statistical analysis ; Studies ; X chromosomes</subject><ispartof>Scientific reports, 2016-10, Vol.6 (1), p.35278-35278, Article 35278</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Oct 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-c7399e460e1c36782fbf64385da319246082260878db2222e7a481fb558744e33</citedby><cites>FETCH-LOGICAL-c563t-c7399e460e1c36782fbf64385da319246082260878db2222e7a481fb558744e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059659/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059659/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,554,729,782,786,866,887,27931,27932,41127,42196,51583,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27731410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-307543$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:134434679$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Loley, Christina</creatorcontrib><creatorcontrib>Alver, Maris</creatorcontrib><creatorcontrib>Assimes, Themistocles L.</creatorcontrib><creatorcontrib>Bjonnes, Andrew</creatorcontrib><creatorcontrib>Goel, Anuj</creatorcontrib><creatorcontrib>Gustafsson, Stefan</creatorcontrib><creatorcontrib>Hernesniemi, Jussi</creatorcontrib><creatorcontrib>Hopewell, Jemma C.</creatorcontrib><creatorcontrib>Kanoni, Stavroula</creatorcontrib><creatorcontrib>Kleber, Marcus E.</creatorcontrib><creatorcontrib>Lau, King Wai</creatorcontrib><creatorcontrib>Lu, Yingchang</creatorcontrib><creatorcontrib>Lyytikäinen, Leo-Pekka</creatorcontrib><creatorcontrib>Nelson, Christopher P.</creatorcontrib><creatorcontrib>Nikpay, Majid</creatorcontrib><creatorcontrib>Qu, Liming</creatorcontrib><creatorcontrib>Salfati, Elias</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>Tukiainen, Taru</creatorcontrib><creatorcontrib>Willenborg, Christina</creatorcontrib><creatorcontrib>Won, Hong-Hee</creatorcontrib><creatorcontrib>Zeng, Lingyao</creatorcontrib><creatorcontrib>Zhang, Weihua</creatorcontrib><creatorcontrib>Anand, Sonia S.</creatorcontrib><creatorcontrib>Beutner, Frank</creatorcontrib><creatorcontrib>Bottinger, Erwin P.</creatorcontrib><creatorcontrib>Clarke, Robert</creatorcontrib><creatorcontrib>Dedoussis, George</creatorcontrib><creatorcontrib>Do, Ron</creatorcontrib><creatorcontrib>Esko, Tõnu</creatorcontrib><creatorcontrib>Eskola, Markku</creatorcontrib><creatorcontrib>Farrall, Martin</creatorcontrib><creatorcontrib>Gauguier, Dominique</creatorcontrib><creatorcontrib>Giedraitis, Vilmantas</creatorcontrib><creatorcontrib>Granger, Christopher B.</creatorcontrib><creatorcontrib>Hall, Alistair S.</creatorcontrib><creatorcontrib>Hamsten, Anders</creatorcontrib><creatorcontrib>Hazen, Stanley L.</creatorcontrib><creatorcontrib>Huang, Jie</creatorcontrib><creatorcontrib>Kähönen, Mika</creatorcontrib><creatorcontrib>Kyriakou, Theodosios</creatorcontrib><creatorcontrib>Laaksonen, Reijo</creatorcontrib><creatorcontrib>Lind, Lars</creatorcontrib><creatorcontrib>Lindgren, Cecilia</creatorcontrib><creatorcontrib>Magnusson, Patrik K. E.</creatorcontrib><creatorcontrib>Marouli, Eirini</creatorcontrib><creatorcontrib>Mihailov, Evelin</creatorcontrib><creatorcontrib>Morris, Andrew P.</creatorcontrib><creatorcontrib>Nikus, Kjell</creatorcontrib><creatorcontrib>Pedersen, Nancy</creatorcontrib><creatorcontrib>Rallidis, Loukianos</creatorcontrib><creatorcontrib>Salomaa, Veikko</creatorcontrib><creatorcontrib>Shah, Svati H.</creatorcontrib><creatorcontrib>Stewart, Alexandre F. R.</creatorcontrib><creatorcontrib>Thompson, John R.</creatorcontrib><creatorcontrib>Zalloua, Pierre A.</creatorcontrib><creatorcontrib>Chambers, John C.</creatorcontrib><creatorcontrib>Collins, Rory</creatorcontrib><creatorcontrib>Ingelsson, Erik</creatorcontrib><creatorcontrib>Iribarren, Carlos</creatorcontrib><creatorcontrib>Karhunen, Pekka J.</creatorcontrib><creatorcontrib>Kooner, Jaspal S.</creatorcontrib><creatorcontrib>Lehtimäki, Terho</creatorcontrib><creatorcontrib>Loos, Ruth J. F.</creatorcontrib><creatorcontrib>März, Winfried</creatorcontrib><creatorcontrib>McPherson, Ruth</creatorcontrib><creatorcontrib>Metspalu, Andres</creatorcontrib><creatorcontrib>Reilly, Muredach P.</creatorcontrib><creatorcontrib>Ripatti, Samuli</creatorcontrib><creatorcontrib>Sanghera, Dharambir K.</creatorcontrib><creatorcontrib>Thiery, Joachim</creatorcontrib><creatorcontrib>Watkins, Hugh</creatorcontrib><creatorcontrib>Deloukas, Panos</creatorcontrib><creatorcontrib>Kathiresan, Sekar</creatorcontrib><creatorcontrib>Samani, Nilesh J.</creatorcontrib><creatorcontrib>Schunkert, Heribert</creatorcontrib><creatorcontrib>Erdmann, Jeanette</creatorcontrib><creatorcontrib>König, Inke R.</creatorcontrib><title>No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the role of X-chromosomal variants in CAD. To fill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000 CAD cases and 58,000 controls from 35 international study cohorts. For quality control, sex-specific filters were used to adequately take the special structure of X-chromosomal data into account. For single study analyses, several logistic regression models were calculated allowing for inactivation of one female X-chromosome, adjusting for sex and investigating interactions between sex and genetic variants. Then, meta-analyses including all 35 studies were conducted using random effects models. None of the investigated models revealed genome-wide significant associations for any variant. Although we analyzed the largest-to-date sample, currently available methods were not able to detect any associations of X-chromosomal variants with CAD.</description><subject>631/208/205/2138</subject><subject>692/4019</subject><subject>Cardiovascular disease</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, X</subject><subject>Cohort Studies</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Females</subject><subject>Filters</subject><subject>Genetic variance</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>Heart diseases</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inactivation</subject><subject>International studies</subject><subject>Internationality</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Meta-analysis</subject><subject>multidisciplinary</subject><subject>Quality control</subject><subject>Regression analysis</subject><subject>Science</subject><subject>Sex</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>X chromosomes</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>D8T</sourceid><recordid>eNp1kktv1DAQxyMEolXpgS-AInEBRMDP2LlUirY8KhW4QMXN8mYnuy6JHeykVb89s93tsgXVB3vk-f3nYU-WPafkHSVcv08RBi6Z0o-yQ0aELBhn7PGefZAdp3RJcElWCVo9zQ6YUpwKSg6z-DXkdUqhcXZ0weehzWchBm_jTV7HEfA4dQlsgvzajav8ZzFbxdCHFHrb5Rc2OuvHlDuPsn6IsAKf3BXkZx61_jYmcl9gtEWN1k1y6Vn2pLVdguPteZT9-Pjh--xzcf7t09msPi8aWfKxaBSvKhAlAdrwUmnWzttScC0XltOKoUMzhpvSiznDBcoKTdu5lFoJAZwfZcUmbrqGYZqbIboe2zLBOrO9-oUWGEmopmu-epAfYlj8Fd0JKReCi1JVqH37oPbUXdQmxKWZJsOJkmKd6mSDI9vDogE_Rtvdz3jP493KLMMVliqrUq7zvdoGiOH3BGk0vUsNdJ31EKZkqOZSrD-cIfryH_QyTPg1HVIVoaVW6rb51xuqiSHhSLW7Yigx6zkzuzlD9sV-9TvybqoQeLN9DXT5JcS9lP9F-wODut4b</recordid><startdate>20161012</startdate><enddate>20161012</enddate><creator>Loley, Christina</creator><creator>Alver, Maris</creator><creator>Assimes, Themistocles L.</creator><creator>Bjonnes, Andrew</creator><creator>Goel, Anuj</creator><creator>Gustafsson, Stefan</creator><creator>Hernesniemi, Jussi</creator><creator>Hopewell, Jemma C.</creator><creator>Kanoni, Stavroula</creator><creator>Kleber, Marcus E.</creator><creator>Lau, King Wai</creator><creator>Lu, Yingchang</creator><creator>Lyytikäinen, Leo-Pekka</creator><creator>Nelson, Christopher P.</creator><creator>Nikpay, Majid</creator><creator>Qu, Liming</creator><creator>Salfati, Elias</creator><creator>Scholz, Markus</creator><creator>Tukiainen, Taru</creator><creator>Willenborg, Christina</creator><creator>Won, Hong-Hee</creator><creator>Zeng, Lingyao</creator><creator>Zhang, Weihua</creator><creator>Anand, Sonia S.</creator><creator>Beutner, Frank</creator><creator>Bottinger, Erwin P.</creator><creator>Clarke, Robert</creator><creator>Dedoussis, George</creator><creator>Do, Ron</creator><creator>Esko, Tõnu</creator><creator>Eskola, Markku</creator><creator>Farrall, Martin</creator><creator>Gauguier, Dominique</creator><creator>Giedraitis, Vilmantas</creator><creator>Granger, Christopher B.</creator><creator>Hall, Alistair S.</creator><creator>Hamsten, Anders</creator><creator>Hazen, Stanley L.</creator><creator>Huang, Jie</creator><creator>Kähönen, Mika</creator><creator>Kyriakou, Theodosios</creator><creator>Laaksonen, Reijo</creator><creator>Lind, Lars</creator><creator>Lindgren, Cecilia</creator><creator>Magnusson, Patrik K. 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F.</creator><creator>März, Winfried</creator><creator>McPherson, Ruth</creator><creator>Metspalu, Andres</creator><creator>Reilly, Muredach P.</creator><creator>Ripatti, Samuli</creator><creator>Sanghera, Dharambir K.</creator><creator>Thiery, Joachim</creator><creator>Watkins, Hugh</creator><creator>Deloukas, Panos</creator><creator>Kathiresan, Sekar</creator><creator>Samani, Nilesh J.</creator><creator>Schunkert, Heribert</creator><creator>Erdmann, Jeanette</creator><creator>König, Inke R.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>ACNBI</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DF2</scope><scope>ZZAVC</scope></search><sort><creationdate>20161012</creationdate><title>No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis</title><author>Loley, Christina ; Alver, Maris ; Assimes, Themistocles L. ; Bjonnes, Andrew ; Goel, Anuj ; Gustafsson, Stefan ; Hernesniemi, Jussi ; Hopewell, Jemma C. ; Kanoni, Stavroula ; Kleber, Marcus E. ; Lau, King Wai ; Lu, Yingchang ; Lyytikäinen, Leo-Pekka ; Nelson, Christopher P. ; Nikpay, Majid ; Qu, Liming ; Salfati, Elias ; Scholz, Markus ; Tukiainen, Taru ; Willenborg, Christina ; Won, Hong-Hee ; Zeng, Lingyao ; Zhang, Weihua ; Anand, Sonia S. ; Beutner, Frank ; Bottinger, Erwin P. ; Clarke, Robert ; Dedoussis, George ; Do, Ron ; Esko, Tõnu ; Eskola, Markku ; Farrall, Martin ; Gauguier, Dominique ; Giedraitis, Vilmantas ; Granger, Christopher B. ; Hall, Alistair S. ; Hamsten, Anders ; Hazen, Stanley L. ; Huang, Jie ; Kähönen, Mika ; Kyriakou, Theodosios ; Laaksonen, Reijo ; Lind, Lars ; Lindgren, Cecilia ; Magnusson, Patrik K. E. ; Marouli, Eirini ; Mihailov, Evelin ; Morris, Andrew P. ; Nikus, Kjell ; Pedersen, Nancy ; Rallidis, Loukianos ; Salomaa, Veikko ; Shah, Svati H. ; Stewart, Alexandre F. R. ; Thompson, John R. ; Zalloua, Pierre A. ; Chambers, John C. ; Collins, Rory ; Ingelsson, Erik ; Iribarren, Carlos ; Karhunen, Pekka J. ; Kooner, Jaspal S. ; Lehtimäki, Terho ; Loos, Ruth J. F. ; März, Winfried ; McPherson, Ruth ; Metspalu, Andres ; Reilly, Muredach P. ; Ripatti, Samuli ; Sanghera, Dharambir K. ; Thiery, Joachim ; Watkins, Hugh ; Deloukas, Panos ; Kathiresan, Sekar ; Samani, Nilesh J. ; Schunkert, Heribert ; Erdmann, Jeanette ; König, Inke R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-c7399e460e1c36782fbf64385da319246082260878db2222e7a481fb558744e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/208/205/2138</topic><topic>692/4019</topic><topic>Cardiovascular disease</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, X</topic><topic>Cohort Studies</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary vessels</topic><topic>Female</topic><topic>Females</topic><topic>Filters</topic><topic>Genetic variance</topic><topic>Genome-wide association studies</topic><topic>Genomes</topic><topic>Heart diseases</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Inactivation</topic><topic>International studies</topic><topic>Internationality</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Meta-analysis</topic><topic>multidisciplinary</topic><topic>Quality control</topic><topic>Regression analysis</topic><topic>Science</topic><topic>Sex</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>X chromosomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loley, Christina</creatorcontrib><creatorcontrib>Alver, Maris</creatorcontrib><creatorcontrib>Assimes, Themistocles L.</creatorcontrib><creatorcontrib>Bjonnes, Andrew</creatorcontrib><creatorcontrib>Goel, Anuj</creatorcontrib><creatorcontrib>Gustafsson, Stefan</creatorcontrib><creatorcontrib>Hernesniemi, Jussi</creatorcontrib><creatorcontrib>Hopewell, Jemma C.</creatorcontrib><creatorcontrib>Kanoni, Stavroula</creatorcontrib><creatorcontrib>Kleber, Marcus E.</creatorcontrib><creatorcontrib>Lau, King Wai</creatorcontrib><creatorcontrib>Lu, Yingchang</creatorcontrib><creatorcontrib>Lyytikäinen, Leo-Pekka</creatorcontrib><creatorcontrib>Nelson, Christopher P.</creatorcontrib><creatorcontrib>Nikpay, Majid</creatorcontrib><creatorcontrib>Qu, Liming</creatorcontrib><creatorcontrib>Salfati, Elias</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>Tukiainen, Taru</creatorcontrib><creatorcontrib>Willenborg, Christina</creatorcontrib><creatorcontrib>Won, Hong-Hee</creatorcontrib><creatorcontrib>Zeng, Lingyao</creatorcontrib><creatorcontrib>Zhang, Weihua</creatorcontrib><creatorcontrib>Anand, Sonia S.</creatorcontrib><creatorcontrib>Beutner, Frank</creatorcontrib><creatorcontrib>Bottinger, Erwin P.</creatorcontrib><creatorcontrib>Clarke, Robert</creatorcontrib><creatorcontrib>Dedoussis, George</creatorcontrib><creatorcontrib>Do, Ron</creatorcontrib><creatorcontrib>Esko, Tõnu</creatorcontrib><creatorcontrib>Eskola, Markku</creatorcontrib><creatorcontrib>Farrall, Martin</creatorcontrib><creatorcontrib>Gauguier, Dominique</creatorcontrib><creatorcontrib>Giedraitis, Vilmantas</creatorcontrib><creatorcontrib>Granger, Christopher B.</creatorcontrib><creatorcontrib>Hall, Alistair S.</creatorcontrib><creatorcontrib>Hamsten, Anders</creatorcontrib><creatorcontrib>Hazen, Stanley L.</creatorcontrib><creatorcontrib>Huang, Jie</creatorcontrib><creatorcontrib>Kähönen, Mika</creatorcontrib><creatorcontrib>Kyriakou, Theodosios</creatorcontrib><creatorcontrib>Laaksonen, Reijo</creatorcontrib><creatorcontrib>Lind, Lars</creatorcontrib><creatorcontrib>Lindgren, Cecilia</creatorcontrib><creatorcontrib>Magnusson, Patrik K. 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F.</creatorcontrib><creatorcontrib>März, Winfried</creatorcontrib><creatorcontrib>McPherson, Ruth</creatorcontrib><creatorcontrib>Metspalu, Andres</creatorcontrib><creatorcontrib>Reilly, Muredach P.</creatorcontrib><creatorcontrib>Ripatti, Samuli</creatorcontrib><creatorcontrib>Sanghera, Dharambir K.</creatorcontrib><creatorcontrib>Thiery, Joachim</creatorcontrib><creatorcontrib>Watkins, Hugh</creatorcontrib><creatorcontrib>Deloukas, Panos</creatorcontrib><creatorcontrib>Kathiresan, Sekar</creatorcontrib><creatorcontrib>Samani, Nilesh J.</creatorcontrib><creatorcontrib>Schunkert, Heribert</creatorcontrib><creatorcontrib>Erdmann, Jeanette</creatorcontrib><creatorcontrib>König, Inke R.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loley, Christina</au><au>Alver, Maris</au><au>Assimes, Themistocles L.</au><au>Bjonnes, Andrew</au><au>Goel, Anuj</au><au>Gustafsson, Stefan</au><au>Hernesniemi, Jussi</au><au>Hopewell, Jemma C.</au><au>Kanoni, Stavroula</au><au>Kleber, Marcus E.</au><au>Lau, King Wai</au><au>Lu, Yingchang</au><au>Lyytikäinen, Leo-Pekka</au><au>Nelson, Christopher P.</au><au>Nikpay, Majid</au><au>Qu, Liming</au><au>Salfati, Elias</au><au>Scholz, Markus</au><au>Tukiainen, Taru</au><au>Willenborg, Christina</au><au>Won, Hong-Hee</au><au>Zeng, Lingyao</au><au>Zhang, Weihua</au><au>Anand, Sonia S.</au><au>Beutner, Frank</au><au>Bottinger, Erwin P.</au><au>Clarke, Robert</au><au>Dedoussis, George</au><au>Do, Ron</au><au>Esko, Tõnu</au><au>Eskola, Markku</au><au>Farrall, Martin</au><au>Gauguier, Dominique</au><au>Giedraitis, Vilmantas</au><au>Granger, Christopher B.</au><au>Hall, Alistair S.</au><au>Hamsten, Anders</au><au>Hazen, Stanley L.</au><au>Huang, Jie</au><au>Kähönen, Mika</au><au>Kyriakou, Theodosios</au><au>Laaksonen, Reijo</au><au>Lind, Lars</au><au>Lindgren, Cecilia</au><au>Magnusson, Patrik K. E.</au><au>Marouli, Eirini</au><au>Mihailov, Evelin</au><au>Morris, Andrew P.</au><au>Nikus, Kjell</au><au>Pedersen, Nancy</au><au>Rallidis, Loukianos</au><au>Salomaa, Veikko</au><au>Shah, Svati H.</au><au>Stewart, Alexandre F. R.</au><au>Thompson, John R.</au><au>Zalloua, Pierre A.</au><au>Chambers, John C.</au><au>Collins, Rory</au><au>Ingelsson, Erik</au><au>Iribarren, Carlos</au><au>Karhunen, Pekka J.</au><au>Kooner, Jaspal S.</au><au>Lehtimäki, Terho</au><au>Loos, Ruth J. F.</au><au>März, Winfried</au><au>McPherson, Ruth</au><au>Metspalu, Andres</au><au>Reilly, Muredach P.</au><au>Ripatti, Samuli</au><au>Sanghera, Dharambir K.</au><au>Thiery, Joachim</au><au>Watkins, Hugh</au><au>Deloukas, Panos</au><au>Kathiresan, Sekar</au><au>Samani, Nilesh J.</au><au>Schunkert, Heribert</au><au>Erdmann, Jeanette</au><au>König, Inke R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-10-12</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>35278</spage><epage>35278</epage><pages>35278-35278</pages><artnum>35278</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the role of X-chromosomal variants in CAD. To fill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000 CAD cases and 58,000 controls from 35 international study cohorts. For quality control, sex-specific filters were used to adequately take the special structure of X-chromosomal data into account. For single study analyses, several logistic regression models were calculated allowing for inactivation of one female X-chromosome, adjusting for sex and investigating interactions between sex and genetic variants. Then, meta-analyses including all 35 studies were conducted using random effects models. None of the investigated models revealed genome-wide significant associations for any variant. Although we analyzed the largest-to-date sample, currently available methods were not able to detect any associations of X-chromosomal variants with CAD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27731410</pmid><doi>10.1038/srep35278</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/208/205/2138 692/4019 Cardiovascular disease Chromosomes Chromosomes, Human, X Cohort Studies Coronary artery Coronary Artery Disease - genetics Coronary vessels Female Females Filters Genetic variance Genome-wide association studies Genomes Heart diseases Humanities and Social Sciences Humans Inactivation International studies Internationality Male Medicin och hälsovetenskap Meta-analysis multidisciplinary Quality control Regression analysis Science Sex Statistical analysis Studies X chromosomes |
| title | No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis |
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