IGFBP3 and MAPK/ERK signaling mediates melatonin‐induced antitumor activity in prostate cancer

Treatment of prostate cancer (PCa), a leading cause of cancer among males, lacks successful strategies especially in advanced, hormone‐refractory stages. Some clinical studies have shown an increase in neuroendocrine‐like cells parallel to the tumor progression but their exact role is a matter of de...

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Veröffentlicht in:	Journal of pineal research 2017-01, Vol.62 (1), p.np-n/a
Hauptverfasser:	Mayo, Juan C., Hevia, David, Quiros‐Gonzalez, Isabel, Rodriguez‐Garcia, Aida, Gonzalez‐Menendez, Pedro, Cepas, Vanesa, Gonzalez‐Pola, Iván, Sainz, Rosa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology androgen signaling Animals Cell Differentiation - drug effects Cell Line, Tumor Disease Models, Animal Enzyme-Linked Immunosorbent Assay Humans IGFBP3 Immunoblotting Insulin-Like Growth Factor Binding Protein 3 - metabolism Male MAP Kinase Signaling System - physiology melatonin Melatonin - metabolism Melatonin - pharmacology Mice Mice, Transgenic Microscopy, Confocal Mitogen-Activated Protein Kinase Kinases - metabolism Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology transgenic adenocarcinoma of the mouse prostate mice
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