Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymm...
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| Veröffentlicht in: | Brain imaging and behavior 2017-10, Vol.11 (5), p.1497-1514 |
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| creator | Guadalupe, Tulio Mathias, Samuel R. Whelan, Christopher D. Zwiers, Marcel P. Abe, Yoshinari Agartz, Ingrid Arias-Vásquez, Alejandro Artiges, Eric Ayesa-Arriola, Rosa Baboyan, Vatche G. Barker, Gareth Baune, Bernhard T. Blangero, John Boedhoe, Premika S.W. Bose, Anushree Brem, Silvia Bromberg, Uli Brooks, Samantha Buitelaar, Jan Cannon, Dara M. Cheng, Yuqi Conrod, Patricia J. Conzelmann, Annette Corvin, Aiden Crivello, Fabrice de Zubicaray, Greig I. de Zwarte, Sonja M.C. Deary, Ian J. Doan, Nhat Trung Donohoe, Gary Dørum, Erlend S. Ehrlich, Stefan Espeseth, Thomas Fouche, Jean-Paul Gallinat, Jürgen Garavan, Hugh Gill, Michael Suarez, Andrea Gonzalez Grabe, Hans J. Grotegerd, Dominik Gruber, Oliver Hagenaars, Saskia Hashimoto, Ryota Hauser, Tobias U. Hoogman, Martine Ittermann, Bernd Jahanshad, Neda Jönsson, Erik G. Jurk, Sarah Kahn, Rene S. Kelly, Sinead Kugel, Harald Kwon, Jun Soo Lemaitre, Herve Lochner, Christine Luciano, Michelle Marquand, Andre F. Martin, Nicholas G. Martinot, Jean-Luc Mataix-Cols, David Mather, Karen McMahon, Katie L. Medland, Sarah E. Menchón, José M. Mothersill, Omar Nakao, Tomohiro Narayanaswaamy, Janardhanan C. Opel, Nils Ophoff, Roel Papadopoulos Orfanos, Dimitri Pauli, Paul Paus, Tomáš Poustka, Luise Reddy, Janardhan YC Roiz-Santiáñez, Roberto Roos, Annerine Royle, Natalie A. Sánchez-Juan, Pascual Schumann, Gunter Shumskaya, Elena Smolka, Michael N. Stein, Dan J. Turner, Jessica A. van der Meer, Dennis Veltman, Dick J. Venkatasubramanian, Ganesan Vetter, Nora C. Vuletic, Daniella Walitza, Susanne Walter, Henrik Wen, Wei Westlye, Lars T. Wolfers, Thomas Wright, Margaret J. Xu, Xiufeng Zhao, JingJing Franke, Barbara Thompson, Paul M. Mazoyer, Bernard Fisher, Simon E. |
| description | The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders. |
| doi_str_mv | 10.1007/s11682-016-9629-z |
| format | Article |
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Mathias, Samuel R. ; Whelan, Christopher D. ; Zwiers, Marcel P. ; Abe, Yoshinari ; Agartz, Ingrid ; Arias-Vásquez, Alejandro ; Artiges, Eric ; Ayesa-Arriola, Rosa ; Baboyan, Vatche G. ; Barker, Gareth ; Baune, Bernhard T. ; Blangero, John ; Boedhoe, Premika S.W. ; Bose, Anushree ; Brem, Silvia ; Bromberg, Uli ; Brooks, Samantha ; Buitelaar, Jan ; Cannon, Dara M. ; Cheng, Yuqi ; Conrod, Patricia J. ; Conzelmann, Annette ; Corvin, Aiden ; Crivello, Fabrice ; de Zubicaray, Greig I. ; de Zwarte, Sonja M.C. ; Deary, Ian J. ; Doan, Nhat Trung ; Donohoe, Gary ; Dørum, Erlend S. ; Ehrlich, Stefan ; Espeseth, Thomas ; Fouche, Jean-Paul ; Gallinat, Jürgen ; Garavan, Hugh ; Gill, Michael ; Suarez, Andrea Gonzalez ; Grabe, Hans J. ; Grotegerd, Dominik ; Gruber, Oliver ; Hagenaars, Saskia ; Hashimoto, Ryota ; Hauser, Tobias U. ; Hoogman, Martine ; Ittermann, Bernd ; Jahanshad, Neda ; Jönsson, Erik G. ; Jurk, Sarah ; Kahn, Rene S. ; Kelly, Sinead ; Kugel, Harald ; Kwon, Jun Soo ; Lemaitre, Herve ; Lochner, Christine ; Luciano, Michelle ; Marquand, Andre F. ; Martin, Nicholas G. ; Martinot, Jean-Luc ; Mataix-Cols, David ; Mather, Karen ; McMahon, Katie L. ; Medland, Sarah E. ; Menchón, José M. ; Mothersill, Omar ; Nakao, Tomohiro ; Narayanaswaamy, Janardhanan C. ; Opel, Nils ; Ophoff, Roel ; Papadopoulos Orfanos, Dimitri ; Pauli, Paul ; Paus, Tomáš ; Poustka, Luise ; Reddy, Janardhan YC ; Roiz-Santiáñez, Roberto ; Roos, Annerine ; Royle, Natalie A. ; Sánchez-Juan, Pascual ; Schumann, Gunter ; Shumskaya, Elena ; Smolka, Michael N. ; Stein, Dan J. ; Turner, Jessica A. ; van der Meer, Dennis ; Veltman, Dick J. ; Venkatasubramanian, Ganesan ; Vetter, Nora C. ; Vuletic, Daniella ; Walitza, Susanne ; Walter, Henrik ; Wen, Wei ; Westlye, Lars T. ; Wolfers, Thomas ; Wright, Margaret J. ; Xu, Xiufeng ; Zhao, JingJing ; Franke, Barbara ; Thompson, Paul M. ; Mazoyer, Bernard ; Fisher, Simon E.</creator><creatorcontrib>Guadalupe, Tulio ; Mathias, Samuel R. ; Whelan, Christopher D. ; Zwiers, Marcel P. ; Abe, Yoshinari ; Agartz, Ingrid ; Arias-Vásquez, Alejandro ; Artiges, Eric ; Ayesa-Arriola, Rosa ; Baboyan, Vatche G. ; Barker, Gareth ; Baune, Bernhard T. ; Blangero, John ; Boedhoe, Premika S.W. ; Bose, Anushree ; Brem, Silvia ; Bromberg, Uli ; Brooks, Samantha ; Buitelaar, Jan ; Cannon, Dara M. ; Cheng, Yuqi ; Conrod, Patricia J. ; Conzelmann, Annette ; Corvin, Aiden ; Crivello, Fabrice ; de Zubicaray, Greig I. ; de Zwarte, Sonja M.C. ; Deary, Ian J. ; Doan, Nhat Trung ; Donohoe, Gary ; Dørum, Erlend S. ; Ehrlich, Stefan ; Espeseth, Thomas ; Fouche, Jean-Paul ; Gallinat, Jürgen ; Garavan, Hugh ; Gill, Michael ; Suarez, Andrea Gonzalez ; Grabe, Hans J. ; Grotegerd, Dominik ; Gruber, Oliver ; Hagenaars, Saskia ; Hashimoto, Ryota ; Hauser, Tobias U. ; Hoogman, Martine ; Ittermann, Bernd ; Jahanshad, Neda ; Jönsson, Erik G. ; Jurk, Sarah ; Kahn, Rene S. ; Kelly, Sinead ; Kugel, Harald ; Kwon, Jun Soo ; Lemaitre, Herve ; Lochner, Christine ; Luciano, Michelle ; Marquand, Andre F. ; Martin, Nicholas G. ; Martinot, Jean-Luc ; Mataix-Cols, David ; Mather, Karen ; McMahon, Katie L. ; Medland, Sarah E. ; Menchón, José M. ; Mothersill, Omar ; Nakao, Tomohiro ; Narayanaswaamy, Janardhanan C. ; Opel, Nils ; Ophoff, Roel ; Papadopoulos Orfanos, Dimitri ; Pauli, Paul ; Paus, Tomáš ; Poustka, Luise ; Reddy, Janardhan YC ; Roiz-Santiáñez, Roberto ; Roos, Annerine ; Royle, Natalie A. ; Sánchez-Juan, Pascual ; Schumann, Gunter ; Shumskaya, Elena ; Smolka, Michael N. ; Stein, Dan J. ; Turner, Jessica A. ; van der Meer, Dennis ; Veltman, Dick J. ; Venkatasubramanian, Ganesan ; Vetter, Nora C. ; Vuletic, Daniella ; Walitza, Susanne ; Walter, Henrik ; Wen, Wei ; Westlye, Lars T. ; Wolfers, Thomas ; Wright, Margaret J. ; Xu, Xiufeng ; Zhao, JingJing ; Franke, Barbara ; Thompson, Paul M. ; Mazoyer, Bernard ; Fisher, Simon E.</creatorcontrib><description>The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-016-9629-z</identifier><identifier>PMID: 27738994</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Adult ; Age ; Age factors ; Aged ; Aging - genetics ; Aging - pathology ; Asymmetry ; Basal ganglia ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain - anatomy & histology ; Brain - diagnostic imaging ; Cerebral hemispheres ; Cognition ; Cognitive science ; Female ; Functional Laterality - genetics ; Ganglia ; Gender aspects ; Genetic factors ; Globus pallidus ; Handedness ; Hemispheres ; Hemispheric laterality ; Heritability ; Hippocampus ; Humans ; Magnetic Resonance Imaging ; Male ; Mental disorders ; Meta-analysis ; Meta-Analysis as Topic ; Middle Aged ; Neuropsychology ; Neuroradiology ; Neuroscience ; Neurosciences ; Organ Size ; Original Research ; Psychiatry ; Putamen ; Quantitative Trait, Heritable ; Sex ; Sex Characteristics ; Sex differences ; Systematic review ; Thalamus ; Young Adult</subject><ispartof>Brain imaging and behavior, 2017-10, Vol.11 (5), p.1497-1514</ispartof><rights>The Author(s) 2016</rights><rights>Brain Imaging and Behavior is a copyright of Springer, 2017.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c678t-212e41556ddc589aa868cfd25ec04c543a5a3076febd20259009a565f03d6e013</citedby><cites>FETCH-LOGICAL-c678t-212e41556ddc589aa868cfd25ec04c543a5a3076febd20259009a565f03d6e013</cites><orcidid>0000-0002-6671-858X ; 0000-0003-2348-125X ; 0000-0003-0970-2837 ; 0000-0002-1242-8990 ; 0000-0001-6950-984X ; 0000-0001-9360-6623 ; 0000-0002-9595-3220 ; 0000-0003-4595-1144 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L.</creatorcontrib><creatorcontrib>Medland, Sarah E.</creatorcontrib><creatorcontrib>Menchón, José M.</creatorcontrib><creatorcontrib>Mothersill, Omar</creatorcontrib><creatorcontrib>Nakao, Tomohiro</creatorcontrib><creatorcontrib>Narayanaswaamy, Janardhanan C.</creatorcontrib><creatorcontrib>Opel, Nils</creatorcontrib><creatorcontrib>Ophoff, Roel</creatorcontrib><creatorcontrib>Papadopoulos Orfanos, Dimitri</creatorcontrib><creatorcontrib>Pauli, Paul</creatorcontrib><creatorcontrib>Paus, Tomáš</creatorcontrib><creatorcontrib>Poustka, Luise</creatorcontrib><creatorcontrib>Reddy, Janardhan YC</creatorcontrib><creatorcontrib>Roiz-Santiáñez, Roberto</creatorcontrib><creatorcontrib>Roos, Annerine</creatorcontrib><creatorcontrib>Royle, Natalie A.</creatorcontrib><creatorcontrib>Sánchez-Juan, Pascual</creatorcontrib><creatorcontrib>Schumann, Gunter</creatorcontrib><creatorcontrib>Shumskaya, Elena</creatorcontrib><creatorcontrib>Smolka, Michael N.</creatorcontrib><creatorcontrib>Stein, Dan J.</creatorcontrib><creatorcontrib>Turner, Jessica A.</creatorcontrib><creatorcontrib>van der Meer, Dennis</creatorcontrib><creatorcontrib>Veltman, Dick J.</creatorcontrib><creatorcontrib>Venkatasubramanian, Ganesan</creatorcontrib><creatorcontrib>Vetter, Nora C.</creatorcontrib><creatorcontrib>Vuletic, Daniella</creatorcontrib><creatorcontrib>Walitza, Susanne</creatorcontrib><creatorcontrib>Walter, Henrik</creatorcontrib><creatorcontrib>Wen, Wei</creatorcontrib><creatorcontrib>Westlye, Lars T.</creatorcontrib><creatorcontrib>Wolfers, Thomas</creatorcontrib><creatorcontrib>Wright, Margaret J.</creatorcontrib><creatorcontrib>Xu, Xiufeng</creatorcontrib><creatorcontrib>Zhao, JingJing</creatorcontrib><creatorcontrib>Franke, Barbara</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>Mazoyer, Bernard</creatorcontrib><creatorcontrib>Fisher, Simon E.</creatorcontrib><title>Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><addtitle>Brain Imaging Behav</addtitle><description>The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age factors</subject><subject>Aged</subject><subject>Aging - genetics</subject><subject>Aging - pathology</subject><subject>Asymmetry</subject><subject>Basal ganglia</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain - diagnostic imaging</subject><subject>Cerebral hemispheres</subject><subject>Cognition</subject><subject>Cognitive science</subject><subject>Female</subject><subject>Functional Laterality - genetics</subject><subject>Ganglia</subject><subject>Gender aspects</subject><subject>Genetic factors</subject><subject>Globus pallidus</subject><subject>Handedness</subject><subject>Hemispheres</subject><subject>Hemispheric laterality</subject><subject>Heritability</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Meta-analysis</subject><subject>Meta-Analysis as Topic</subject><subject>Middle Aged</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neuroscience</subject><subject>Neurosciences</subject><subject>Organ Size</subject><subject>Original Research</subject><subject>Psychiatry</subject><subject>Putamen</subject><subject>Quantitative Trait, Heritable</subject><subject>Sex</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Systematic review</subject><subject>Thalamus</subject><subject>Young 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Springer</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-6671-858X</orcidid><orcidid>https://orcid.org/0000-0003-2348-125X</orcidid><orcidid>https://orcid.org/0000-0003-0970-2837</orcidid><orcidid>https://orcid.org/0000-0002-1242-8990</orcidid><orcidid>https://orcid.org/0000-0001-6950-984X</orcidid><orcidid>https://orcid.org/0000-0001-9360-6623</orcidid><orcidid>https://orcid.org/0000-0002-9595-3220</orcidid><orcidid>https://orcid.org/0000-0003-4595-1144</orcidid><orcidid>https://orcid.org/0000-0002-9473-4536</orcidid><orcidid>https://orcid.org/0000-0001-9000-6227</orcidid></search><sort><creationdate>20171001</creationdate><title>Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex</title><author>Guadalupe, Tulio ; Mathias, Samuel R. ; Whelan, Christopher D. ; Zwiers, Marcel P. ; Abe, Yoshinari ; Agartz, Ingrid ; Arias-Vásquez, Alejandro ; Artiges, Eric ; Ayesa-Arriola, Rosa ; Baboyan, Vatche G. ; Barker, Gareth ; Baune, Bernhard T. ; Blangero, John ; Boedhoe, Premika S.W. ; Bose, Anushree ; Brem, Silvia ; Bromberg, Uli ; Brooks, Samantha ; Buitelaar, Jan ; Cannon, Dara M. ; Cheng, Yuqi ; Conrod, Patricia J. ; Conzelmann, Annette ; Corvin, Aiden ; Crivello, Fabrice ; de Zubicaray, Greig I. ; de Zwarte, Sonja M.C. ; Deary, Ian J. ; Doan, Nhat Trung ; Donohoe, Gary ; Dørum, Erlend S. ; Ehrlich, Stefan ; Espeseth, Thomas ; Fouche, Jean-Paul ; Gallinat, Jürgen ; Garavan, Hugh ; Gill, Michael ; Suarez, Andrea Gonzalez ; Grabe, Hans J. ; Grotegerd, Dominik ; Gruber, Oliver ; Hagenaars, Saskia ; Hashimoto, Ryota ; Hauser, Tobias U. ; Hoogman, Martine ; Ittermann, Bernd ; Jahanshad, Neda ; Jönsson, Erik G. ; Jurk, Sarah ; Kahn, Rene S. ; Kelly, Sinead ; Kugel, Harald ; Kwon, Jun Soo ; Lemaitre, Herve ; Lochner, Christine ; Luciano, Michelle ; Marquand, Andre F. ; Martin, Nicholas G. ; Martinot, Jean-Luc ; Mataix-Cols, David ; Mather, Karen ; McMahon, Katie L. ; Medland, Sarah E. ; Menchón, José M. ; Mothersill, Omar ; Nakao, Tomohiro ; Narayanaswaamy, Janardhanan C. ; Opel, Nils ; Ophoff, Roel ; Papadopoulos Orfanos, Dimitri ; Pauli, Paul ; Paus, Tomáš ; Poustka, Luise ; Reddy, Janardhan YC ; Roiz-Santiáñez, Roberto ; Roos, Annerine ; Royle, Natalie A. ; Sánchez-Juan, Pascual ; Schumann, Gunter ; Shumskaya, Elena ; Smolka, Michael N. ; Stein, Dan J. ; Turner, Jessica A. ; van der Meer, Dennis ; Veltman, Dick J. ; Venkatasubramanian, Ganesan ; Vetter, Nora C. ; Vuletic, Daniella ; Walitza, Susanne ; Walter, Henrik ; Wen, Wei ; Westlye, Lars T. ; Wolfers, Thomas ; Wright, Margaret J. ; Xu, Xiufeng ; Zhao, JingJing ; Franke, Barbara ; Thompson, Paul M. ; Mazoyer, Bernard ; Fisher, Simon E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c678t-212e41556ddc589aa868cfd25ec04c543a5a3076febd20259009a565f03d6e013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age factors</topic><topic>Aged</topic><topic>Aging - genetics</topic><topic>Aging - pathology</topic><topic>Asymmetry</topic><topic>Basal ganglia</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Brain - anatomy & histology</topic><topic>Brain - diagnostic imaging</topic><topic>Cerebral hemispheres</topic><topic>Cognition</topic><topic>Cognitive science</topic><topic>Female</topic><topic>Functional Laterality - genetics</topic><topic>Ganglia</topic><topic>Gender aspects</topic><topic>Genetic factors</topic><topic>Globus pallidus</topic><topic>Handedness</topic><topic>Hemispheres</topic><topic>Hemispheric laterality</topic><topic>Heritability</topic><topic>Hippocampus</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Meta-analysis</topic><topic>Meta-Analysis as Topic</topic><topic>Middle Aged</topic><topic>Neuropsychology</topic><topic>Neuroradiology</topic><topic>Neuroscience</topic><topic>Neurosciences</topic><topic>Organ Size</topic><topic>Original Research</topic><topic>Psychiatry</topic><topic>Putamen</topic><topic>Quantitative Trait, Heritable</topic><topic>Sex</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Systematic review</topic><topic>Thalamus</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guadalupe, Tulio</creatorcontrib><creatorcontrib>Mathias, Samuel R.</creatorcontrib><creatorcontrib>Whelan, Christopher 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text</collection><jtitle>Brain imaging and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guadalupe, Tulio</au><au>Mathias, Samuel R.</au><au>Whelan, Christopher D.</au><au>Zwiers, Marcel P.</au><au>Abe, Yoshinari</au><au>Agartz, Ingrid</au><au>Arias-Vásquez, Alejandro</au><au>Artiges, Eric</au><au>Ayesa-Arriola, Rosa</au><au>Baboyan, Vatche G.</au><au>Barker, Gareth</au><au>Baune, Bernhard T.</au><au>Blangero, John</au><au>Boedhoe, Premika S.W.</au><au>Bose, Anushree</au><au>Brem, Silvia</au><au>Bromberg, Uli</au><au>Brooks, Samantha</au><au>Buitelaar, Jan</au><au>Cannon, Dara M.</au><au>Cheng, Yuqi</au><au>Conrod, Patricia J.</au><au>Conzelmann, Annette</au><au>Corvin, Aiden</au><au>Crivello, Fabrice</au><au>de Zubicaray, Greig I.</au><au>de Zwarte, Sonja M.C.</au><au>Deary, Ian J.</au><au>Doan, Nhat Trung</au><au>Donohoe, Gary</au><au>Dørum, Erlend S.</au><au>Ehrlich, Stefan</au><au>Espeseth, Thomas</au><au>Fouche, Jean-Paul</au><au>Gallinat, Jürgen</au><au>Garavan, Hugh</au><au>Gill, Michael</au><au>Suarez, Andrea Gonzalez</au><au>Grabe, Hans J.</au><au>Grotegerd, Dominik</au><au>Gruber, Oliver</au><au>Hagenaars, Saskia</au><au>Hashimoto, Ryota</au><au>Hauser, Tobias U.</au><au>Hoogman, Martine</au><au>Ittermann, Bernd</au><au>Jahanshad, Neda</au><au>Jönsson, Erik G.</au><au>Jurk, Sarah</au><au>Kahn, Rene S.</au><au>Kelly, Sinead</au><au>Kugel, Harald</au><au>Kwon, Jun Soo</au><au>Lemaitre, Herve</au><au>Lochner, Christine</au><au>Luciano, Michelle</au><au>Marquand, Andre F.</au><au>Martin, Nicholas G.</au><au>Martinot, Jean-Luc</au><au>Mataix-Cols, David</au><au>Mather, Karen</au><au>McMahon, Katie L.</au><au>Medland, Sarah E.</au><au>Menchón, José M.</au><au>Mothersill, Omar</au><au>Nakao, Tomohiro</au><au>Narayanaswaamy, Janardhanan C.</au><au>Opel, Nils</au><au>Ophoff, Roel</au><au>Papadopoulos Orfanos, Dimitri</au><au>Pauli, Paul</au><au>Paus, Tomáš</au><au>Poustka, Luise</au><au>Reddy, Janardhan YC</au><au>Roiz-Santiáñez, Roberto</au><au>Roos, Annerine</au><au>Royle, Natalie A.</au><au>Sánchez-Juan, Pascual</au><au>Schumann, Gunter</au><au>Shumskaya, Elena</au><au>Smolka, Michael N.</au><au>Stein, Dan J.</au><au>Turner, Jessica A.</au><au>van der Meer, Dennis</au><au>Veltman, Dick J.</au><au>Venkatasubramanian, Ganesan</au><au>Vetter, Nora C.</au><au>Vuletic, Daniella</au><au>Walitza, Susanne</au><au>Walter, Henrik</au><au>Wen, Wei</au><au>Westlye, Lars T.</au><au>Wolfers, Thomas</au><au>Wright, Margaret J.</au><au>Xu, Xiufeng</au><au>Zhao, JingJing</au><au>Franke, Barbara</au><au>Thompson, Paul M.</au><au>Mazoyer, Bernard</au><au>Fisher, Simon E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><addtitle>Brain Imaging Behav</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>11</volume><issue>5</issue><spage>1497</spage><epage>1514</epage><pages>1497-1514</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><abstract>The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27738994</pmid><doi>10.1007/s11682-016-9629-z</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-6671-858X</orcidid><orcidid>https://orcid.org/0000-0003-2348-125X</orcidid><orcidid>https://orcid.org/0000-0003-0970-2837</orcidid><orcidid>https://orcid.org/0000-0002-1242-8990</orcidid><orcidid>https://orcid.org/0000-0001-6950-984X</orcidid><orcidid>https://orcid.org/0000-0001-9360-6623</orcidid><orcidid>https://orcid.org/0000-0002-9595-3220</orcidid><orcidid>https://orcid.org/0000-0003-4595-1144</orcidid><orcidid>https://orcid.org/0000-0002-9473-4536</orcidid><orcidid>https://orcid.org/0000-0001-9000-6227</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1931-7557 |
| ispartof | Brain imaging and behavior, 2017-10, Vol.11 (5), p.1497-1514 |
| issn | 1931-7557 1931-7565 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_501756 |
| source | MEDLINE; SWEPUB Freely available online; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Age Age factors Aged Aging - genetics Aging - pathology Asymmetry Basal ganglia Biomedical and Life Sciences Biomedicine Brain Brain - anatomy & histology Brain - diagnostic imaging Cerebral hemispheres Cognition Cognitive science Female Functional Laterality - genetics Ganglia Gender aspects Genetic factors Globus pallidus Handedness Hemispheres Hemispheric laterality Heritability Hippocampus Humans Magnetic Resonance Imaging Male Mental disorders Meta-analysis Meta-Analysis as Topic Middle Aged Neuropsychology Neuroradiology Neuroscience Neurosciences Organ Size Original Research Psychiatry Putamen Quantitative Trait, Heritable Sex Sex Characteristics Sex differences Systematic review Thalamus Young Adult |
| title | Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex |
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