Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4

Type 2 diabetic (T2D) patients often develop early cognitive and sensorimotor impairments. The pathophysiological mechanisms behind these problems are largely unknown. Recent studies demonstrate that dysfunctional γ-aminobutyric acid (GABAergic) neurons are involved in age-related cognitive decline....

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Veröffentlicht in:	Bioscience reports 2016-12, Vol.36 (6), p.e00421-e00421
Hauptverfasser:	Larsson, Martin, Lietzau, Grazyna, Nathanson, David, Östenson, Claes-Göran, Mallard, Carina, Johansson, Maria E, Nyström, Thomas, Patrone, Cesare, Darsalia, Vladimer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Medicine Calbindin 2 - metabolism Calbindins - metabolism Corpus Striatum - metabolism Corpus Striatum - physiopathology Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology GABAergic Neurons - metabolism GABAergic Neurons - physiology gamma-Aminobutyric Acid - metabolism Glucagon-Like Peptide-1 Receptor - metabolism Glutamate Decarboxylase - metabolism Medicin och hälsovetenskap Medicinska grundvetenskaper Neocortex - metabolism Neocortex - physiopathology Original Paper Original Papers Parvalbumins - metabolism Peptides - metabolism Rats Rats, Wistar Venoms - metabolism
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