Six years without pholcodine; Norwegians are significantly less IgE‐sensitized and clinically more tolerant to neuromuscular blocking agents

Background As a strong inducer of IgE antibodies to substituted ammonium ion epitopes (QAI), pholcodine (PHO) is a postulated cause of allergic anaphylaxis to neuromuscular blocking agents (NMBAs). Three years after withdrawal of PHO in Norway, a significant reduction in IgE sensitization and anaphy...

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Veröffentlicht in:	Allergy (Copenhagen) 2017-05, Vol.72 (5), p.813-819
Hauptverfasser:	Pater, G. H., Florvaag, E., Johansson, S. G. O., Irgens, Å., Petersen, M. N. H., Guttormsen, A. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Allergies anaesthesia anaphylaxis Anaphylaxis - epidemiology Anaphylaxis - etiology Anesthesia Child Codeine - adverse effects Codeine - analogs & derivatives Codeine - chemistry Drug Hypersensitivity - epidemiology Drug Hypersensitivity - immunology Female Follow-Up Studies Humans IgE antibodies Immunoglobulin E - blood Immunoglobulin E - immunology Immunoglobulins Male Middle Aged Morpholines - adverse effects Morpholines - chemistry Neuromuscular Blocking Agents - adverse effects Norway - epidemiology pholcodine Population Surveillance Prevalence Safety-Based Drug Withdrawals Young Adult
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