Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide

Major depressive disorder (MDD) is a substantial burden to patients, families, and society, but many patients cannot be treated adequately. Rodent experiments suggest that the neuropeptide galanin (GAL) and its three G protein-coupled receptors, GAL1–3, are involved in mood regulation. To explore th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-12, Vol.113 (52), p.E8472-E8481
Hauptverfasser:	Barde, Swapnali, Rüegg, Joelle, Prud’homme, Josée, Ekström, Tomas J., Palkovits, Miklos, Turecki, Gustavo, Bagdy, Gyorgy, Ihnatko, Robert, Theodorsson, Elvar, Juhasz, Gabriella, Diaz-Heijtz, Rochellys, Mechawar, Naguib, Hökfelt, Tomas G. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Affect Aged Antidepressants Biological Sciences Brain - metabolism Brain - pathology Brain Mapping Case-Control Studies Depressive Disorder, Major - genetics Depressive Disorder, Major - metabolism DNA Methylation Dorsal Raphe Nucleus - metabolism Female Galanin - genetics Galanin - metabolism Gene Expression Profiling Gene Expression Regulation Humans Locus Coeruleus - metabolism Male Middle Aged Pathogenesis Peptides PNAS Plus Receptor, Galanin, Type 1 - genetics Receptor, Galanin, Type 1 - metabolism Receptor, Galanin, Type 3 - genetics Receptor, Galanin, Type 3 - metabolism Ribonucleic acid RNA Rodents Self control Sex Factors Suicide
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