Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease

Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials soon. Most of the approaches currently under development involve transplantation of immature progenitors that subsequently undergo phenotypic and functional maturation in vivo, and predicting the long-term graf...

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Veröffentlicht in:	Cell stem cell 2017-01, Vol.20 (1), p.135-148
Hauptverfasser:	Kirkeby, Agnete, Nolbrant, Sara, Tiklova, Katarina, Heuer, Andreas, Kee, Nigel, Cardoso, Tiago, Ottosson, Daniella Rylander, Lelos, Mariah J., Rifes, Pedro, Dunnett, Stephen B., Grealish, Shane, Perlmann, Thomas, Parmar, Malin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Medicine Biomarkers - metabolism Cell Differentiation - drug effects Cell Lineage - drug effects Cells, Cultured Clinical Medicine Clinical Progress diencephalon Dopamine - metabolism dopaminergic neurons Dopaminergic Neurons - cytology Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Extracellular Matrix - drug effects Extracellular Matrix - metabolism Female FGF8 Fibroblast Growth Factor 8 - metabolism GMP good manufacturing practice hESCs human embryonic stem cells Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - drug effects Human Embryonic Stem Cells - transplantation Humans Klinisk medicin Laminin - pharmacology Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Mesencephalon - metabolism MHB midbrain-hindbrain boundary Neurologi Neurology Neurosciences Neurovetenskaper Parkinson Disease - therapy Parkinson's disease Rats, Sprague-Dawley Reproducibility of Results Sequence Analysis, RNA Stem Cell Transplantation STN subthalamic nucleus Subthalamic Nucleus - cytology Subthalamic Nucleus - metabolism Time Factors Translational Research, Biomedical transplantation Treatment Outcome ventral midbrain
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