G‐CSF mobilized peripheral blood stem cell collection for allogeneic transplantation in healthy donors: Analysis of factors affecting yield

Mobilized PBSC are the main source for allogeneic HSCT. We aimed to evaluate factors that affect CD34+ cell yield including the donor's age, gender, BSA, processed blood volume and the method of G‐CSF dose calculation. Data from 170 healthy donors were analyzed. The concentration of CD34+ cells...

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Veröffentlicht in:	Journal of clinical apheresis 2017-12, Vol.32 (6), p.384-391
Hauptverfasser:	Machaczka, Maciej, Hägglund, Hans, Staver, Emma, Joks, Monika, Hassan, Moustapha, Wahlin, Björn Engelbrekt, Axdorph Nygell, Ulla
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Antigens, CD34 - analysis Antigens, CD34 - drug effects Blood collection Dose-Response Relationship, Drug Female G-CSF Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte Colony-Stimulating Factor - therapeutic use healthy donors Healthy Volunteers Hematopoietic Stem Cell Mobilization - methods Humans Male Medicin och hälsovetenskap Middle Aged mobilization PBSC donation Peripheral Blood Stem Cell Transplantation - methods Peripheral Blood Stem Cells Sex Factors Transplantation, Homologous Young Adult
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Zusammenfassung:	Mobilized PBSC are the main source for allogeneic HSCT. We aimed to evaluate factors that affect CD34+ cell yield including the donor's age, gender, BSA, processed blood volume and the method of G‐CSF dose calculation. Data from 170 healthy donors were analyzed. The concentration of CD34+ cells in the peripheral blood (PB) and the processed volume of blood were significantly correlated to CD34+ cells yield (P
ISSN:	0733-2459 1098-1101 1098-1101
DOI:	10.1002/jca.21524