Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes

At the end of protein-coding genes, RNA polymerase (Pol) II undergoes a concerted transition that involves 3′-processing of the pre-mRNA and transcription termination. Here, we present a genome-wide analysis of the 3′-transition in budding yeast. We find that the 3′-transition globally requires the...

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Veröffentlicht in:	Molecular cell 2017-04, Vol.66 (1), p.38-49.e6
Hauptverfasser:	Baejen, Carlo, Andreani, Jessica, Torkler, Phillipp, Battaglia, Sofia, Schwalb, Bjoern, Lidschreiber, Michael, Maier, Kerstin C., Boltendahl, Andrea, Rus, Petra, Esslinger, Stephanie, Söding, Johannes, Cramer, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism DNA, Fungal - genetics DNA, Fungal - metabolism Exoribonucleases - genetics Exoribonucleases - metabolism Models, Genetic mRNA Cleavage and Polyadenylation Factors - genetics mRNA Cleavage and Polyadenylation Factors - metabolism poly-adenylation pre-mRNA 3′-processing Protein Binding RNA 3' End Processing RNA polymerase II RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA Precursors - biosynthesis RNA Precursors - genetics RNA, Fungal - biosynthesis RNA, Fungal - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Torpedo nuclease transcription termination Transcriptional Elongation Factors - genetics Transcriptional Elongation Factors - metabolism
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