Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells

The mTOR pathway is a critical determinant of cell persistence and growth wherein mTOR complex 1 (mTORC1) mediates a balance between growth factor stimuli and nutrient availability. Amino acids or glucose facilitates mTORC1 activation by inducing RagA GTPase recruitment of mTORC1 to the lysosomal ou...

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Veröffentlicht in:	The Journal of clinical investigation 2017-04, Vol.127 (4), p.1405-1413
Hauptverfasser:	Kalaitzidis, Demetrios, Lee, Dongjun, Efeyan, Alejo, Kfoury, Youmna, Nayyar, Naema, Sykes, David B, Mercier, Francois E, Papazian, Ani, Baryawno, Ninib, Victora, Gabriel D, Neuberg, Donna, Sabatini, David M, Scadden, David T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Amino Acids - physiology Anemia Animals Biomedical research Blood Cell Differentiation Cells, Cultured Cellular signal transduction Cloning Experiments Flow cytometry Gene expression Genetic aspects Growth Health aspects Hematopoietic stem cells Hematopoietic Stem Cells - physiology Homeostasis Hospitals Kinases Mechanistic Target of Rapamycin Complex 1 Medicin och hälsovetenskap Mice, Inbred C57BL Mice, Transgenic Microscopy Monomeric GTP-Binding Proteins - metabolism Multiprotein Complexes - metabolism Neutrophils Phosphotransferases Ragas Rodents Software Spleen Stem cells Stress, Physiological TOR Serine-Threonine Kinases - metabolism Transplants & implants
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