United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)
Background There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic p...
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| Veröffentlicht in: | United European Gastroenterology Journal 2017-03, Vol.5 (2), p.153-199 |
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| creator | Löhr, J Matthias Dominguez-Munoz, Enrique Rosendahl, Jonas Besselink, Marc Mayerle, Julia Lerch, Markus M Haas, Stephan Akisik, Fatih Kartalis, Nikolaos Iglesias-Garcia, Julio Keller, Jutta Boermeester, Marja Werner, Jens Dumonceau, Jean-Marc Fockens, Paul Drewes, Asbjorn Ceyhan, Gürlap Lindkvist, Björn Drenth, Joost Ewald, Nils Hardt, Philip de Madaria, Enrique Witt, Heiko Schneider, Alexander Manfredi, Riccardo Brøndum, Frøkjer J Rudolf, Sasa Bollen, Thomas Bruno, Marco |
| description | Background
There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed these European guidelines using an evidence-based approach.
Methods
Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers.
Results
The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as ‘strong' and plenary voting revealed ‘strong agreement' for 99 (98%) recommendations.
Conclusions
The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research. |
| doi_str_mv | 10.1177/2050640616684695 |
| format | Article |
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There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed these European guidelines using an evidence-based approach.
Methods
Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers.
Results
The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as ‘strong' and plenary voting revealed ‘strong agreement' for 99 (98%) recommendations.
Conclusions
The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.</description><identifier>ISSN: 2050-6406</identifier><identifier>EISSN: 2050-6414</identifier><identifier>DOI: 10.1177/2050640616684695</identifier><identifier>PMID: 28344786</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Chronic pancreatitis ; Development and Evaluation ; diabetes mellitus ; endoscopic therapy ; evidence‐based ; Gastroenterologi och hepatologi ; Gastroenterology & Hepatology ; Gastroenterology and Hepatology ; Grading of Recommendations Assessment ; guidelines ; pancreatic exocrine insufficiency ; Review</subject><ispartof>United European Gastroenterology Journal, 2017-03, Vol.5 (2), p.153-199</ispartof><rights>Author(s) 2017</rights><rights>2017 The Authors. UEG Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology</rights><rights>Author(s) 2017 2017 United European Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6261-bd7fb52f4de39920110f187cdd651db1507b052711d917c75f891d6a376ea1fc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349368/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349368/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,550,723,776,780,788,881,1411,11541,27899,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1177%2F2050640616684695$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28344786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/253337$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:135458709$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Löhr, J Matthias</creatorcontrib><creatorcontrib>Dominguez-Munoz, Enrique</creatorcontrib><creatorcontrib>Rosendahl, Jonas</creatorcontrib><creatorcontrib>Besselink, Marc</creatorcontrib><creatorcontrib>Mayerle, Julia</creatorcontrib><creatorcontrib>Lerch, Markus M</creatorcontrib><creatorcontrib>Haas, Stephan</creatorcontrib><creatorcontrib>Akisik, Fatih</creatorcontrib><creatorcontrib>Kartalis, Nikolaos</creatorcontrib><creatorcontrib>Iglesias-Garcia, Julio</creatorcontrib><creatorcontrib>Keller, Jutta</creatorcontrib><creatorcontrib>Boermeester, Marja</creatorcontrib><creatorcontrib>Werner, Jens</creatorcontrib><creatorcontrib>Dumonceau, Jean-Marc</creatorcontrib><creatorcontrib>Fockens, Paul</creatorcontrib><creatorcontrib>Drewes, Asbjorn</creatorcontrib><creatorcontrib>Ceyhan, Gürlap</creatorcontrib><creatorcontrib>Lindkvist, Björn</creatorcontrib><creatorcontrib>Drenth, Joost</creatorcontrib><creatorcontrib>Ewald, Nils</creatorcontrib><creatorcontrib>Hardt, Philip</creatorcontrib><creatorcontrib>de Madaria, Enrique</creatorcontrib><creatorcontrib>Witt, Heiko</creatorcontrib><creatorcontrib>Schneider, Alexander</creatorcontrib><creatorcontrib>Manfredi, Riccardo</creatorcontrib><creatorcontrib>Brøndum, Frøkjer J</creatorcontrib><creatorcontrib>Rudolf, Sasa</creatorcontrib><creatorcontrib>Bollen, Thomas</creatorcontrib><creatorcontrib>Bruno, Marco</creatorcontrib><creatorcontrib>HaPanEU/UEG Working Group</creatorcontrib><title>United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)</title><title>United European Gastroenterology Journal</title><addtitle>United European Gastroenterol J</addtitle><description>Background
There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed these European guidelines using an evidence-based approach.
Methods
Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers.
Results
The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as ‘strong' and plenary voting revealed ‘strong agreement' for 99 (98%) recommendations.
Conclusions
The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.</description><subject>Chronic pancreatitis</subject><subject>Development and Evaluation</subject><subject>diabetes mellitus</subject><subject>endoscopic therapy</subject><subject>evidence‐based</subject><subject>Gastroenterologi och hepatologi</subject><subject>Gastroenterology & Hepatology</subject><subject>Gastroenterology and Hepatology</subject><subject>Grading of Recommendations Assessment</subject><subject>guidelines</subject><subject>pancreatic exocrine insufficiency</subject><subject>Review</subject><issn>2050-6406</issn><issn>2050-6414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>D8T</sourceid><recordid>eNqFkk1v1DAQhiMEolXpnRPKsRxC7cSfFySotlukSnBgz5ZjT7IuWTvYSavl1-PVLqsWqeCLZ14_86HxFMVbjD5gzPlljShiBDHMmCBM0hfF6U6qGMHk5dFG7KQ4T-kO5SMEqWvyujipRUMIF-y0-LXybgJbLuYYRtC-XOo0xQB-ghiG0G9LuHcWvIGq1SmD_ZzdwXlIZRdiOa2htE73PiSXSu3tTol63JahK806Bu9MOWpvIujJTZm5uNHftF-s3r8pXnV6SHB-uM-K1fXi-9VNdft1-eXq021lWM1w1VretbTuiIVGyhphjDosuLGWUWxbTBFvEa05xlZibjjthMSW6YYz0LgzzVlR7fOmBxjnVo3RbXTcqqCdOkg_sgWKSIG4-Cffz6PKUj_v-Jo2TcMz_3HPZ3gD1uTZRT08CXv64t1a9eFe0YbIhu0KXhwSxPBzhjSpjUsGhkF7CHNSWAhMiJSSZhTtURNDShG6YxmM1G4r1N9bkUPePW7vGPBnBzIg98CDG2D734RqtVjWn68RYgI_mpXuQd2FOfr8lc838xvxLtKA</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Löhr, J Matthias</creator><creator>Dominguez-Munoz, Enrique</creator><creator>Rosendahl, Jonas</creator><creator>Besselink, Marc</creator><creator>Mayerle, Julia</creator><creator>Lerch, Markus M</creator><creator>Haas, Stephan</creator><creator>Akisik, Fatih</creator><creator>Kartalis, Nikolaos</creator><creator>Iglesias-Garcia, Julio</creator><creator>Keller, Jutta</creator><creator>Boermeester, Marja</creator><creator>Werner, Jens</creator><creator>Dumonceau, Jean-Marc</creator><creator>Fockens, Paul</creator><creator>Drewes, Asbjorn</creator><creator>Ceyhan, Gürlap</creator><creator>Lindkvist, Björn</creator><creator>Drenth, Joost</creator><creator>Ewald, Nils</creator><creator>Hardt, Philip</creator><creator>de Madaria, Enrique</creator><creator>Witt, Heiko</creator><creator>Schneider, Alexander</creator><creator>Manfredi, Riccardo</creator><creator>Brøndum, Frøkjer J</creator><creator>Rudolf, Sasa</creator><creator>Bollen, Thomas</creator><creator>Bruno, Marco</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>201703</creationdate><title>United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)</title><author>Löhr, J Matthias ; Dominguez-Munoz, Enrique ; Rosendahl, Jonas ; Besselink, Marc ; Mayerle, Julia ; Lerch, Markus M ; Haas, Stephan ; Akisik, Fatih ; Kartalis, Nikolaos ; Iglesias-Garcia, Julio ; Keller, Jutta ; Boermeester, Marja ; Werner, Jens ; Dumonceau, Jean-Marc ; Fockens, Paul ; Drewes, Asbjorn ; Ceyhan, Gürlap ; Lindkvist, Björn ; Drenth, Joost ; Ewald, Nils ; Hardt, Philip ; de Madaria, Enrique ; Witt, Heiko ; Schneider, Alexander ; Manfredi, Riccardo ; Brøndum, Frøkjer J ; Rudolf, Sasa ; Bollen, Thomas ; Bruno, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6261-bd7fb52f4de39920110f187cdd651db1507b052711d917c75f891d6a376ea1fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Chronic pancreatitis</topic><topic>Development and Evaluation</topic><topic>diabetes mellitus</topic><topic>endoscopic therapy</topic><topic>evidence‐based</topic><topic>Gastroenterologi och hepatologi</topic><topic>Gastroenterology & Hepatology</topic><topic>Gastroenterology and Hepatology</topic><topic>Grading of Recommendations Assessment</topic><topic>guidelines</topic><topic>pancreatic exocrine insufficiency</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Löhr, J Matthias</creatorcontrib><creatorcontrib>Dominguez-Munoz, Enrique</creatorcontrib><creatorcontrib>Rosendahl, Jonas</creatorcontrib><creatorcontrib>Besselink, Marc</creatorcontrib><creatorcontrib>Mayerle, Julia</creatorcontrib><creatorcontrib>Lerch, Markus M</creatorcontrib><creatorcontrib>Haas, Stephan</creatorcontrib><creatorcontrib>Akisik, Fatih</creatorcontrib><creatorcontrib>Kartalis, Nikolaos</creatorcontrib><creatorcontrib>Iglesias-Garcia, Julio</creatorcontrib><creatorcontrib>Keller, Jutta</creatorcontrib><creatorcontrib>Boermeester, Marja</creatorcontrib><creatorcontrib>Werner, Jens</creatorcontrib><creatorcontrib>Dumonceau, Jean-Marc</creatorcontrib><creatorcontrib>Fockens, Paul</creatorcontrib><creatorcontrib>Drewes, Asbjorn</creatorcontrib><creatorcontrib>Ceyhan, Gürlap</creatorcontrib><creatorcontrib>Lindkvist, Björn</creatorcontrib><creatorcontrib>Drenth, Joost</creatorcontrib><creatorcontrib>Ewald, Nils</creatorcontrib><creatorcontrib>Hardt, Philip</creatorcontrib><creatorcontrib>de Madaria, Enrique</creatorcontrib><creatorcontrib>Witt, Heiko</creatorcontrib><creatorcontrib>Schneider, Alexander</creatorcontrib><creatorcontrib>Manfredi, Riccardo</creatorcontrib><creatorcontrib>Brøndum, Frøkjer J</creatorcontrib><creatorcontrib>Rudolf, Sasa</creatorcontrib><creatorcontrib>Bollen, Thomas</creatorcontrib><creatorcontrib>Bruno, Marco</creatorcontrib><creatorcontrib>HaPanEU/UEG Working Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>United European Gastroenterology Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Löhr, J Matthias</au><au>Dominguez-Munoz, Enrique</au><au>Rosendahl, Jonas</au><au>Besselink, Marc</au><au>Mayerle, Julia</au><au>Lerch, Markus M</au><au>Haas, Stephan</au><au>Akisik, Fatih</au><au>Kartalis, Nikolaos</au><au>Iglesias-Garcia, Julio</au><au>Keller, Jutta</au><au>Boermeester, Marja</au><au>Werner, Jens</au><au>Dumonceau, Jean-Marc</au><au>Fockens, Paul</au><au>Drewes, Asbjorn</au><au>Ceyhan, Gürlap</au><au>Lindkvist, Björn</au><au>Drenth, Joost</au><au>Ewald, Nils</au><au>Hardt, Philip</au><au>de Madaria, Enrique</au><au>Witt, Heiko</au><au>Schneider, Alexander</au><au>Manfredi, Riccardo</au><au>Brøndum, Frøkjer J</au><au>Rudolf, Sasa</au><au>Bollen, Thomas</au><au>Bruno, Marco</au><aucorp>HaPanEU/UEG Working Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)</atitle><jtitle>United European Gastroenterology Journal</jtitle><addtitle>United European Gastroenterol J</addtitle><date>2017-03</date><risdate>2017</risdate><volume>5</volume><issue>2</issue><spage>153</spage><epage>199</epage><pages>153-199</pages><issn>2050-6406</issn><eissn>2050-6414</eissn><abstract>Background
There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed these European guidelines using an evidence-based approach.
Methods
Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers.
Results
The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as ‘strong' and plenary voting revealed ‘strong agreement' for 99 (98%) recommendations.
Conclusions
The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>28344786</pmid><doi>10.1177/2050640616684695</doi><tpages>47</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 2050-6406 |
| ispartof | United European Gastroenterology Journal, 2017-03, Vol.5 (2), p.153-199 |
| issn | 2050-6406 2050-6414 |
| language | eng |
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| source | Wiley Online Library Open Access |
| subjects | Chronic pancreatitis Development and Evaluation diabetes mellitus endoscopic therapy evidence‐based Gastroenterologi och hepatologi Gastroenterology & Hepatology Gastroenterology and Hepatology Grading of Recommendations Assessment guidelines pancreatic exocrine insufficiency Review |
| title | United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) |
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