Staphylococcus aureus enterotoxin sensitization is associated with allergic poly‐sensitization and allergic multimorbidity in adolescents
Background Staphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been associated with allergic diseases. From the Tromsø Study Fit Futures 2, we have previously shown an association between S. aureus carriage and severe allergic disease and allergic multim...
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| Veröffentlicht in: | Allergy (Copenhagen) 2017-10, Vol.72 (10), p.1548-1555 |
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| creator | Sørensen, M. Klingenberg, C. Wickman, M. Sollid, J. U. E. Furberg, A‐S. Bachert, C. Bousquet, J. |
| description | Background
Staphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been associated with allergic diseases. From the Tromsø Study Fit Futures 2, we have previously shown an association between S. aureus carriage and severe allergic disease and allergic multimorbidity. However, the role of S. aureus carriage and SE sensitization on allergic multimorbidity and allergic sensitization is unclear.
Objective
To study associations of both nasal S. aureus carriage and SE sensitization to allergic disease and allergic sensitization.
Methods
A cross‐sectional study of a school‐based cohort in late adolescence (aged 18‐19 years: The Tromsø Study Fit Futures 2). Self‐reported allergic diseases were assessed using the Mechanisms of the Development of ALLergy questionnaire (MeDALL). Participants were tested for nasal S. aureus carriage, serum total IgE and specific IgE to SEs, and food and inhalant allergens.
Results
A total of 868 participants were studied. Sensitization to at least one food or inhalant allergen was found in 319 of 765 (41.7%), and to at least one SE in 173 of 656 (26.2%) participants. SE sensitization, but not S. aureus carriage, was associated with poly‐sensitization to food and inhalant allergens. SE‐sensitized participants had higher median specific IgE to inhalant allergens (41.4 kUA/L, IQR 10.1‐118.4) compared to non‐SE‐sensitized participants (18.0 kUA/L, IQR 5.5‐48.6, P=.004), but not to food allergens. SE sensitization was associated with allergic multimorbidity.
Conclusion
Sensitization to SEs may play a role in the development of allergen poly‐sensitization and allergic multimorbidity. |
| doi_str_mv | 10.1111/all.13175 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_497824</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1884462976</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4255-8a9f333bb9a63229c69542b57285d6acb3fda8eb65ab328c9f261980a87ff5c13</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EokNhwQugSGxgkda_ib0cVUCRIrEA1pbjOIyLEwfb6RBW7NnwjDwJHjK0KhLeXOvq8zn3-gDwFMEzlM-5cu4MEVSze2CDiOClEILdBxuIICspI_wEPIrxCkJYYwEfghPMSc0JpRvw431S025xXnut51ioOZhczJhM8Ml_tWMRzRhtst9Usn4sbGZi9NqqZLpib9OuyPYmfLK6mLxbfn3_efeBGrtbYphdsoMPre1sWoqsrjrvTNTZMD4GD3rlonlyrKfg4-tXHy4uy-bdm7cX26bUFDNWciV6QkjbClURjIWuBKO4ZTXmrKuUbknfKW7aiqmWYK5FjyskOFS87numETkF5aob92aaWzkFO6iwSK-sPLY-55uRVNQc08y_XPmdcnfgy20jDz2I6qomgl4ftF-s7BT8l9nEJAebt3NOjcbPUSLOKa2wqKuMPv8HvfJzGPPmEgnCCedC4FtzHXyMwfQ3EyAoD-nL_LnyT_qZfXZUnNvBdDfk37gzcL4Ce-vM8n8luW2aVfI3Jmm9sA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1938388992</pqid></control><display><type>article</type><title>Staphylococcus aureus enterotoxin sensitization is associated with allergic poly‐sensitization and allergic multimorbidity in adolescents</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><creator>Sørensen, M. ; Klingenberg, C. ; Wickman, M. ; Sollid, J. U. E. ; Furberg, A‐S. ; Bachert, C. ; Bousquet, J.</creator><creatorcontrib>Sørensen, M. ; Klingenberg, C. ; Wickman, M. ; Sollid, J. U. E. ; Furberg, A‐S. ; Bachert, C. ; Bousquet, J.</creatorcontrib><description>Background
Staphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been associated with allergic diseases. From the Tromsø Study Fit Futures 2, we have previously shown an association between S. aureus carriage and severe allergic disease and allergic multimorbidity. However, the role of S. aureus carriage and SE sensitization on allergic multimorbidity and allergic sensitization is unclear.
Objective
To study associations of both nasal S. aureus carriage and SE sensitization to allergic disease and allergic sensitization.
Methods
A cross‐sectional study of a school‐based cohort in late adolescence (aged 18‐19 years: The Tromsø Study Fit Futures 2). Self‐reported allergic diseases were assessed using the Mechanisms of the Development of ALLergy questionnaire (MeDALL). Participants were tested for nasal S. aureus carriage, serum total IgE and specific IgE to SEs, and food and inhalant allergens.
Results
A total of 868 participants were studied. Sensitization to at least one food or inhalant allergen was found in 319 of 765 (41.7%), and to at least one SE in 173 of 656 (26.2%) participants. SE sensitization, but not S. aureus carriage, was associated with poly‐sensitization to food and inhalant allergens. SE‐sensitized participants had higher median specific IgE to inhalant allergens (41.4 kUA/L, IQR 10.1‐118.4) compared to non‐SE‐sensitized participants (18.0 kUA/L, IQR 5.5‐48.6, P=.004), but not to food allergens. SE sensitization was associated with allergic multimorbidity.
Conclusion
Sensitization to SEs may play a role in the development of allergen poly‐sensitization and allergic multimorbidity.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/all.13175</identifier><identifier>PMID: 28378344</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adolescents ; Age Factors ; Allergens ; Allergens - immunology ; Allergic disease ; Allergic diseases ; Allergic multimorbidity ; Allergies ; Allergology ; Antigens, Bacterial - immunology ; Carrier State ; Comorbidity ; Cross Reactions - immunology ; Cross-Sectional Studies ; Enterotoxins ; Enterotoxins - immunology ; Female ; Food ; Food allergies ; Gram-positive bacteria ; Humans ; Hypersensitivity - epidemiology ; Hypersensitivity - immunology ; Immunization ; Immunoglobulin E ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Immunology ; Life Sciences ; Male ; Multimorbidity ; Odds Ratio ; Poly‐sensitization ; Prevalence ; Staphylococcus aureus ; Staphylococcus aureus - immunology ; Staphylococcus aureus Enterotoxins ; Teenagers</subject><ispartof>Allergy (Copenhagen), 2017-10, Vol.72 (10), p.1548-1555</ispartof><rights>2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4255-8a9f333bb9a63229c69542b57285d6acb3fda8eb65ab328c9f261980a87ff5c13</citedby><cites>FETCH-LOGICAL-c4255-8a9f333bb9a63229c69542b57285d6acb3fda8eb65ab328c9f261980a87ff5c13</cites><orcidid>0000-0003-4742-1665 ; 0000-0002-0581-4789</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fall.13175$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fall.13175$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,777,781,882,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28378344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01767394$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:136744533$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Sørensen, M.</creatorcontrib><creatorcontrib>Klingenberg, C.</creatorcontrib><creatorcontrib>Wickman, M.</creatorcontrib><creatorcontrib>Sollid, J. U. E.</creatorcontrib><creatorcontrib>Furberg, A‐S.</creatorcontrib><creatorcontrib>Bachert, C.</creatorcontrib><creatorcontrib>Bousquet, J.</creatorcontrib><title>Staphylococcus aureus enterotoxin sensitization is associated with allergic poly‐sensitization and allergic multimorbidity in adolescents</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background
Staphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been associated with allergic diseases. From the Tromsø Study Fit Futures 2, we have previously shown an association between S. aureus carriage and severe allergic disease and allergic multimorbidity. However, the role of S. aureus carriage and SE sensitization on allergic multimorbidity and allergic sensitization is unclear.
Objective
To study associations of both nasal S. aureus carriage and SE sensitization to allergic disease and allergic sensitization.
Methods
A cross‐sectional study of a school‐based cohort in late adolescence (aged 18‐19 years: The Tromsø Study Fit Futures 2). Self‐reported allergic diseases were assessed using the Mechanisms of the Development of ALLergy questionnaire (MeDALL). Participants were tested for nasal S. aureus carriage, serum total IgE and specific IgE to SEs, and food and inhalant allergens.
Results
A total of 868 participants were studied. Sensitization to at least one food or inhalant allergen was found in 319 of 765 (41.7%), and to at least one SE in 173 of 656 (26.2%) participants. SE sensitization, but not S. aureus carriage, was associated with poly‐sensitization to food and inhalant allergens. SE‐sensitized participants had higher median specific IgE to inhalant allergens (41.4 kUA/L, IQR 10.1‐118.4) compared to non‐SE‐sensitized participants (18.0 kUA/L, IQR 5.5‐48.6, P=.004), but not to food allergens. SE sensitization was associated with allergic multimorbidity.
Conclusion
Sensitization to SEs may play a role in the development of allergen poly‐sensitization and allergic multimorbidity.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Age Factors</subject><subject>Allergens</subject><subject>Allergens - immunology</subject><subject>Allergic disease</subject><subject>Allergic diseases</subject><subject>Allergic multimorbidity</subject><subject>Allergies</subject><subject>Allergology</subject><subject>Antigens, Bacterial - immunology</subject><subject>Carrier State</subject><subject>Comorbidity</subject><subject>Cross Reactions - immunology</subject><subject>Cross-Sectional Studies</subject><subject>Enterotoxins</subject><subject>Enterotoxins - immunology</subject><subject>Female</subject><subject>Food</subject><subject>Food allergies</subject><subject>Gram-positive bacteria</subject><subject>Humans</subject><subject>Hypersensitivity - epidemiology</subject><subject>Hypersensitivity - immunology</subject><subject>Immunization</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Multimorbidity</subject><subject>Odds Ratio</subject><subject>Poly‐sensitization</subject><subject>Prevalence</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - immunology</subject><subject>Staphylococcus aureus Enterotoxins</subject><subject>Teenagers</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EokNhwQugSGxgkda_ib0cVUCRIrEA1pbjOIyLEwfb6RBW7NnwjDwJHjK0KhLeXOvq8zn3-gDwFMEzlM-5cu4MEVSze2CDiOClEILdBxuIICspI_wEPIrxCkJYYwEfghPMSc0JpRvw431S025xXnut51ioOZhczJhM8Ml_tWMRzRhtst9Usn4sbGZi9NqqZLpib9OuyPYmfLK6mLxbfn3_efeBGrtbYphdsoMPre1sWoqsrjrvTNTZMD4GD3rlonlyrKfg4-tXHy4uy-bdm7cX26bUFDNWciV6QkjbClURjIWuBKO4ZTXmrKuUbknfKW7aiqmWYK5FjyskOFS87numETkF5aob92aaWzkFO6iwSK-sPLY-55uRVNQc08y_XPmdcnfgy20jDz2I6qomgl4ftF-s7BT8l9nEJAebt3NOjcbPUSLOKa2wqKuMPv8HvfJzGPPmEgnCCedC4FtzHXyMwfQ3EyAoD-nL_LnyT_qZfXZUnNvBdDfk37gzcL4Ce-vM8n8luW2aVfI3Jmm9sA</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Sørensen, M.</creator><creator>Klingenberg, C.</creator><creator>Wickman, M.</creator><creator>Sollid, J. U. E.</creator><creator>Furberg, A‐S.</creator><creator>Bachert, C.</creator><creator>Bousquet, J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0003-4742-1665</orcidid><orcidid>https://orcid.org/0000-0002-0581-4789</orcidid></search><sort><creationdate>201710</creationdate><title>Staphylococcus aureus enterotoxin sensitization is associated with allergic poly‐sensitization and allergic multimorbidity in adolescents</title><author>Sørensen, M. ; Klingenberg, C. ; Wickman, M. ; Sollid, J. U. E. ; Furberg, A‐S. ; Bachert, C. ; Bousquet, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4255-8a9f333bb9a63229c69542b57285d6acb3fda8eb65ab328c9f261980a87ff5c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Age Factors</topic><topic>Allergens</topic><topic>Allergens - immunology</topic><topic>Allergic disease</topic><topic>Allergic diseases</topic><topic>Allergic multimorbidity</topic><topic>Allergies</topic><topic>Allergology</topic><topic>Antigens, Bacterial - immunology</topic><topic>Carrier State</topic><topic>Comorbidity</topic><topic>Cross Reactions - immunology</topic><topic>Cross-Sectional Studies</topic><topic>Enterotoxins</topic><topic>Enterotoxins - immunology</topic><topic>Female</topic><topic>Food</topic><topic>Food allergies</topic><topic>Gram-positive bacteria</topic><topic>Humans</topic><topic>Hypersensitivity - epidemiology</topic><topic>Hypersensitivity - immunology</topic><topic>Immunization</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Multimorbidity</topic><topic>Odds Ratio</topic><topic>Poly‐sensitization</topic><topic>Prevalence</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - immunology</topic><topic>Staphylococcus aureus Enterotoxins</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sørensen, M.</creatorcontrib><creatorcontrib>Klingenberg, C.</creatorcontrib><creatorcontrib>Wickman, M.</creatorcontrib><creatorcontrib>Sollid, J. U. E.</creatorcontrib><creatorcontrib>Furberg, A‐S.</creatorcontrib><creatorcontrib>Bachert, C.</creatorcontrib><creatorcontrib>Bousquet, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sørensen, M.</au><au>Klingenberg, C.</au><au>Wickman, M.</au><au>Sollid, J. U. E.</au><au>Furberg, A‐S.</au><au>Bachert, C.</au><au>Bousquet, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Staphylococcus aureus enterotoxin sensitization is associated with allergic poly‐sensitization and allergic multimorbidity in adolescents</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2017-10</date><risdate>2017</risdate><volume>72</volume><issue>10</issue><spage>1548</spage><epage>1555</epage><pages>1548-1555</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><abstract>Background
Staphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been associated with allergic diseases. From the Tromsø Study Fit Futures 2, we have previously shown an association between S. aureus carriage and severe allergic disease and allergic multimorbidity. However, the role of S. aureus carriage and SE sensitization on allergic multimorbidity and allergic sensitization is unclear.
Objective
To study associations of both nasal S. aureus carriage and SE sensitization to allergic disease and allergic sensitization.
Methods
A cross‐sectional study of a school‐based cohort in late adolescence (aged 18‐19 years: The Tromsø Study Fit Futures 2). Self‐reported allergic diseases were assessed using the Mechanisms of the Development of ALLergy questionnaire (MeDALL). Participants were tested for nasal S. aureus carriage, serum total IgE and specific IgE to SEs, and food and inhalant allergens.
Results
A total of 868 participants were studied. Sensitization to at least one food or inhalant allergen was found in 319 of 765 (41.7%), and to at least one SE in 173 of 656 (26.2%) participants. SE sensitization, but not S. aureus carriage, was associated with poly‐sensitization to food and inhalant allergens. SE‐sensitized participants had higher median specific IgE to inhalant allergens (41.4 kUA/L, IQR 10.1‐118.4) compared to non‐SE‐sensitized participants (18.0 kUA/L, IQR 5.5‐48.6, P=.004), but not to food allergens. SE sensitization was associated with allergic multimorbidity.
Conclusion
Sensitization to SEs may play a role in the development of allergen poly‐sensitization and allergic multimorbidity.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>28378344</pmid><doi>10.1111/all.13175</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4742-1665</orcidid><orcidid>https://orcid.org/0000-0002-0581-4789</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content |
| subjects | Adolescent Adolescents Age Factors Allergens Allergens - immunology Allergic disease Allergic diseases Allergic multimorbidity Allergies Allergology Antigens, Bacterial - immunology Carrier State Comorbidity Cross Reactions - immunology Cross-Sectional Studies Enterotoxins Enterotoxins - immunology Female Food Food allergies Gram-positive bacteria Humans Hypersensitivity - epidemiology Hypersensitivity - immunology Immunization Immunoglobulin E Immunoglobulin E - blood Immunoglobulin E - immunology Immunology Life Sciences Male Multimorbidity Odds Ratio Poly‐sensitization Prevalence Staphylococcus aureus Staphylococcus aureus - immunology Staphylococcus aureus Enterotoxins Teenagers |
| title | Staphylococcus aureus enterotoxin sensitization is associated with allergic poly‐sensitization and allergic multimorbidity in adolescents |
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