Serum periostin relates to type‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish GA(2)LEN
Background Periostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma re...
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| Veröffentlicht in: | Allergy (Copenhagen) 2017-11, Vol.72 (11), p.1753-1760 |
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| creator | James, A. Janson, C. Malinovschi, A. Holweg, C. Alving, K. Ono, J. Ohta, S. Ek, A. Middelveld, R. Dahlén, B. Forsberg, B. Izuhara, K. Dahlén, S.‐E. |
| description | Background
Periostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear.
Aim
To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics.
Methods
Serum periostin was examined by ELISA in 1100 subjects aged 17‐76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil‐derived neurotoxin (U‐EDN), and serum eosinophil cationic protein (S‐ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life.
Results
Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U‐EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma.
Conclusion
We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype‐specific biomarker in asthma. |
| doi_str_mv | 10.1111/all.13181 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_497629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1951411542</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5321-39502a3a7582feebde13d73d8182e0d1b5e93ef9451114d826477a4629401d643</originalsourceid><addsrcrecordid>eNp9kstu1DAUhi0EokNhwQsgS2yoRFpfJzG7UVsKUgSLAlvLMz6ZSUni4ItGs-MBWPQZ-ySYyVBWxRtbR9__LY5_hF5SckrzOTNdd0o5regjNKNcVYVSSj5GM0KJLITk1RF6FsINIaRkijxFR6zK1JzLGfp1DT71eATfuhDbAXvoTISAo8NxN8Ldz1uG26HpTN-b2LoBm8HiLg1r3KRhtZ_klAlx05t3-MJEgxvvehw3gDvj14BHN6Zun82ypQlg8cptnI_4egu2DRt8tXjDTurLT8_Rk8Z0AV4c7mP09f3ll_MPRf356uP5oi5WkjNacCUJM9yUsmINwNIC5bbktqIVA2LpUoLi0Cgh83KErdhclKURc6YEoXYu-DEqJm_YwpiWevRtb_xOO9Pqw-h7foEWqsypzL99kL9ovy2082udkuZclbz8r_4f3idNOZ_0ryd-9O5HghD1jUt-yBvQVEkqKJWCZepkolbeheChufdSov_UQOca6H0NMvvqYEzLHuw9-fffM3A2Adu2g93DJr2o60n5G9l3vlk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1951411542</pqid></control><display><type>article</type><title>Serum periostin relates to type‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish GA(2)LEN</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>James, A. ; Janson, C. ; Malinovschi, A. ; Holweg, C. ; Alving, K. ; Ono, J. ; Ohta, S. ; Ek, A. ; Middelveld, R. ; Dahlén, B. ; Forsberg, B. ; Izuhara, K. ; Dahlén, S.‐E.</creator><creatorcontrib>James, A. ; Janson, C. ; Malinovschi, A. ; Holweg, C. ; Alving, K. ; Ono, J. ; Ohta, S. ; Ek, A. ; Middelveld, R. ; Dahlén, B. ; Forsberg, B. ; Izuhara, K. ; Dahlén, S.‐E.</creatorcontrib><description>Background
Periostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear.
Aim
To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics.
Methods
Serum periostin was examined by ELISA in 1100 subjects aged 17‐76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil‐derived neurotoxin (U‐EDN), and serum eosinophil cationic protein (S‐ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life.
Results
Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U‐EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma.
Conclusion
We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype‐specific biomarker in asthma.</description><identifier>ISSN: 0105-4538</identifier><identifier>ISSN: 1398-9995</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/all.13181</identifier><identifier>PMID: 28398635</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Allergies ; Asthma ; Asthma - blood ; Asthma - epidemiology ; Asthma - pathology ; Asthma - physiopathology ; Biomarkers ; Body mass ; Body mass index ; Case-Control Studies ; Cell Adhesion Molecules - blood ; Enzyme-linked immunosorbent assay ; Eosinophil cationic protein ; Eosinophil-derived neurotoxin ; Humans ; Immunoglobulin E ; Inflammation ; Inflammation - etiology ; Lung - pathology ; Lung - physiopathology ; Lungs ; Middle Aged ; periostin ; Quality of life ; Respiratory function ; Rhinitis ; Rhinosinusitis ; Sinusitis ; Smoking ; Sweden ; Young Adult</subject><ispartof>Allergy (Copenhagen), 2017-11, Vol.72 (11), p.1753-1760</ispartof><rights>2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5321-39502a3a7582feebde13d73d8182e0d1b5e93ef9451114d826477a4629401d643</citedby><cites>FETCH-LOGICAL-c5321-39502a3a7582feebde13d73d8182e0d1b5e93ef9451114d826477a4629401d643</cites><orcidid>0000-0003-2698-8419</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fall.13181$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fall.13181$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28398635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133629$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339737$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:136864857$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>James, A.</creatorcontrib><creatorcontrib>Janson, C.</creatorcontrib><creatorcontrib>Malinovschi, A.</creatorcontrib><creatorcontrib>Holweg, C.</creatorcontrib><creatorcontrib>Alving, K.</creatorcontrib><creatorcontrib>Ono, J.</creatorcontrib><creatorcontrib>Ohta, S.</creatorcontrib><creatorcontrib>Ek, A.</creatorcontrib><creatorcontrib>Middelveld, R.</creatorcontrib><creatorcontrib>Dahlén, B.</creatorcontrib><creatorcontrib>Forsberg, B.</creatorcontrib><creatorcontrib>Izuhara, K.</creatorcontrib><creatorcontrib>Dahlén, S.‐E.</creatorcontrib><title>Serum periostin relates to type‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish GA(2)LEN</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background
Periostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear.
Aim
To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics.
Methods
Serum periostin was examined by ELISA in 1100 subjects aged 17‐76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil‐derived neurotoxin (U‐EDN), and serum eosinophil cationic protein (S‐ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life.
Results
Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U‐EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma.
Conclusion
We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype‐specific biomarker in asthma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - epidemiology</subject><subject>Asthma - pathology</subject><subject>Asthma - physiopathology</subject><subject>Biomarkers</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Eosinophil cationic protein</subject><subject>Eosinophil-derived neurotoxin</subject><subject>Humans</subject><subject>Immunoglobulin E</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Lung - pathology</subject><subject>Lung - physiopathology</subject><subject>Lungs</subject><subject>Middle Aged</subject><subject>periostin</subject><subject>Quality of life</subject><subject>Respiratory function</subject><subject>Rhinitis</subject><subject>Rhinosinusitis</subject><subject>Sinusitis</subject><subject>Smoking</subject><subject>Sweden</subject><subject>Young Adult</subject><issn>0105-4538</issn><issn>1398-9995</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kstu1DAUhi0EokNhwQsgS2yoRFpfJzG7UVsKUgSLAlvLMz6ZSUni4ItGs-MBWPQZ-ySYyVBWxRtbR9__LY5_hF5SckrzOTNdd0o5regjNKNcVYVSSj5GM0KJLITk1RF6FsINIaRkijxFR6zK1JzLGfp1DT71eATfuhDbAXvoTISAo8NxN8Ldz1uG26HpTN-b2LoBm8HiLg1r3KRhtZ_klAlx05t3-MJEgxvvehw3gDvj14BHN6Zun82ypQlg8cptnI_4egu2DRt8tXjDTurLT8_Rk8Z0AV4c7mP09f3ll_MPRf356uP5oi5WkjNacCUJM9yUsmINwNIC5bbktqIVA2LpUoLi0Cgh83KErdhclKURc6YEoXYu-DEqJm_YwpiWevRtb_xOO9Pqw-h7foEWqsypzL99kL9ovy2082udkuZclbz8r_4f3idNOZ_0ryd-9O5HghD1jUt-yBvQVEkqKJWCZepkolbeheChufdSov_UQOca6H0NMvvqYEzLHuw9-fffM3A2Adu2g93DJr2o60n5G9l3vlk</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>James, A.</creator><creator>Janson, C.</creator><creator>Malinovschi, A.</creator><creator>Holweg, C.</creator><creator>Alving, K.</creator><creator>Ono, J.</creator><creator>Ohta, S.</creator><creator>Ek, A.</creator><creator>Middelveld, R.</creator><creator>Dahlén, B.</creator><creator>Forsberg, B.</creator><creator>Izuhara, K.</creator><creator>Dahlén, S.‐E.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D93</scope><scope>DF2</scope><orcidid>https://orcid.org/0000-0003-2698-8419</orcidid></search><sort><creationdate>201711</creationdate><title>Serum periostin relates to type‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish GA(2)LEN</title><author>James, A. ; Janson, C. ; Malinovschi, A. ; Holweg, C. ; Alving, K. ; Ono, J. ; Ohta, S. ; Ek, A. ; Middelveld, R. ; Dahlén, B. ; Forsberg, B. ; Izuhara, K. ; Dahlén, S.‐E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5321-39502a3a7582feebde13d73d8182e0d1b5e93ef9451114d826477a4629401d643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Allergies</topic><topic>Asthma</topic><topic>Asthma - blood</topic><topic>Asthma - epidemiology</topic><topic>Asthma - pathology</topic><topic>Asthma - physiopathology</topic><topic>Biomarkers</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Case-Control Studies</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Eosinophil cationic protein</topic><topic>Eosinophil-derived neurotoxin</topic><topic>Humans</topic><topic>Immunoglobulin E</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Lung - pathology</topic><topic>Lung - physiopathology</topic><topic>Lungs</topic><topic>Middle Aged</topic><topic>periostin</topic><topic>Quality of life</topic><topic>Respiratory function</topic><topic>Rhinitis</topic><topic>Rhinosinusitis</topic><topic>Sinusitis</topic><topic>Smoking</topic><topic>Sweden</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>James, A.</creatorcontrib><creatorcontrib>Janson, C.</creatorcontrib><creatorcontrib>Malinovschi, A.</creatorcontrib><creatorcontrib>Holweg, C.</creatorcontrib><creatorcontrib>Alving, K.</creatorcontrib><creatorcontrib>Ono, J.</creatorcontrib><creatorcontrib>Ohta, S.</creatorcontrib><creatorcontrib>Ek, A.</creatorcontrib><creatorcontrib>Middelveld, R.</creatorcontrib><creatorcontrib>Dahlén, B.</creatorcontrib><creatorcontrib>Forsberg, B.</creatorcontrib><creatorcontrib>Izuhara, K.</creatorcontrib><creatorcontrib>Dahlén, S.‐E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>James, A.</au><au>Janson, C.</au><au>Malinovschi, A.</au><au>Holweg, C.</au><au>Alving, K.</au><au>Ono, J.</au><au>Ohta, S.</au><au>Ek, A.</au><au>Middelveld, R.</au><au>Dahlén, B.</au><au>Forsberg, B.</au><au>Izuhara, K.</au><au>Dahlén, S.‐E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum periostin relates to type‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish GA(2)LEN</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2017-11</date><risdate>2017</risdate><volume>72</volume><issue>11</issue><spage>1753</spage><epage>1760</epage><pages>1753-1760</pages><issn>0105-4538</issn><issn>1398-9995</issn><eissn>1398-9995</eissn><abstract>Background
Periostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear.
Aim
To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics.
Methods
Serum periostin was examined by ELISA in 1100 subjects aged 17‐76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil‐derived neurotoxin (U‐EDN), and serum eosinophil cationic protein (S‐ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life.
Results
Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U‐EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma.
Conclusion
We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype‐specific biomarker in asthma.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>28398635</pmid><doi>10.1111/all.13181</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2698-8419</orcidid></addata></record> |
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| ispartof | Allergy (Copenhagen), 2017-11, Vol.72 (11), p.1753-1760 |
| issn | 0105-4538 1398-9995 1398-9995 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Allergies Asthma Asthma - blood Asthma - epidemiology Asthma - pathology Asthma - physiopathology Biomarkers Body mass Body mass index Case-Control Studies Cell Adhesion Molecules - blood Enzyme-linked immunosorbent assay Eosinophil cationic protein Eosinophil-derived neurotoxin Humans Immunoglobulin E Inflammation Inflammation - etiology Lung - pathology Lung - physiopathology Lungs Middle Aged periostin Quality of life Respiratory function Rhinitis Rhinosinusitis Sinusitis Smoking Sweden Young Adult |
| title | Serum periostin relates to type‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish GA(2)LEN |
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