Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson’s and Alzheimer’s disease

Myeloperoxidase (MPO) is a key enzyme in inflammatory and degenerative processes, although conflicting reports have been presented concerning its expression in the brain. We studied the cellular localization of MPO and compared numbers of MPO cells in various brain regions between neurologically hea...

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Veröffentlicht in:	Cell and tissue research 2017-09, Vol.369 (3), p.445-454
Hauptverfasser:	Gellhaar, Sandra, Sunnemark, Dan, Eriksson, Håkan, Olson, Lars, Galter, Dagmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Aged Aged, 80 and over Alzheimer disease Alzheimer Disease - enzymology Alzheimer Disease - pathology Alzheimer's disease Analysis Animal models Animals Biomedical and Life Sciences Biomedicine Bone marrow Brain Brain - enzymology Brain - pathology Cellular biology Cerebellum Cortex (frontal) Dopamine Enzymes Female frontal lobe Glial fibrillary acidic protein hippocampus Human Genetics Humans Immunoreactivity in situ hybridization Inflammation Localization Macrophages Male Mesencephalon messenger RNA mice Microglia Middle Aged Molecular Medicine Monocytes Movement disorders mRNA Myeloid cells myeloperoxidase Nerve Degeneration - enzymology Nerve Degeneration - pathology Neurodegeneration Neurodegenerative diseases neuroglia Neurons Parenchyma parenchyma (animal tissue) Parkinson disease Parkinson Disease - enzymology Parkinson Disease - pathology Parkinson's disease patients Peroxidase Peroxidase - metabolism Plaques Proteomics Putamen rats Rats, Sprague-Dawley Regular Regular Article β-Amyloid
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