Impact of cytosine methylation on DNA binding specificities of human transcription factors

The majority of CpG dinucleotides in the human genome are methylated at cytosine bases. However, active gene regulatory elements are generally hypomethylated relative to their flanking regions, and the binding of some transcription factors (TFs) is diminished by methylation of their target sequences...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-05, Vol.356 (6337), p.502-502
Hauptverfasser:	Yin, Yimeng, Morgunova, Ekaterina, Jolma, Arttu, Kaasinen, Eevi, Sahu, Biswajyoti, Khund-Sayeed, Syed, Das, Pratyush K., Kivioja, Teemu, Dave, Kashyap, Zhong, Fan, Nitta, Kazuhiro R., Taipale, Minna, Popov, Alexander, Ginno, Paul A., Domcke, Silvia, Yan, Jian, Schübeler, Dirk, Vinson, Charles, Taipale, Jussi
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Bisulfite CDX2 protein Cell differentiation Cell division Chromatin CpG Islands Crystal structure Cytosine Cytosine - chemistry Deoxyribonucleic acid Differentiation (biology) Dinucleoside Phosphates - chemistry DNA DNA - chemistry DNA Methylation DNA microarrays DNA structure Embryo cells Embryogenesis Enrichment Epigenesis, Genetic Epigenetics ETS protein Evolution Fractions Gene regulation Gene sequencing Gene silencing Genes Genetics Genome, Human Genomes Guanine Heredity Homeobox Humans Hydrophobicity Immunoprecipitation Individualized Instruction Inhibition Ligands Logos Methylation Nucleotide sequence Nucleotides Preferences Protein Binding Protein Domains Proteins Regulatory mechanisms (biology) RESEARCH ARTICLE SUMMARY SELEX Aptamer Technique Stem cells Steric hindrance Structural analysis Structural Analysis (Linguistics) Structural Analysis (Science) Transcription factors Transcription Factors - chemistry Transcription Factors - classification
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