A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

A subset of Kras and p53 mutant cancer cells acts as a Wnt-producing niche for another cancer cell subset, and porcupine inhibition disrupts Wnt secretion in this niche, thereby suppressing proliferative potential and leading to therapeutic benefit. Lung cancer niche drives tumour growth Lung adenoc...

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Veröffentlicht in:	Nature (London) 2017-05, Vol.545 (7654), p.355-359
Hauptverfasser:	Tammela, Tuomas, Sanchez-Rivera, Francisco J., Cetinbas, Naniye Malli, Wu, Katherine, Joshi, Nikhil S., Helenius, Katja, Park, Yoona, Azimi, Roxana, Kerper, Natanya R., Wesselhoeft, R. Alexander, Gu, Xin, Schmidt, Leah, Cornwall-Brady, Milton, Yilmaz, Ömer H., Xue, Wen, Katajisto, Pekka, Bhutkar, Arjun, Jacks, Tyler
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/31 13/89 38 38/109 38/77 42 42/44 631/67/1059/602 631/67/1612/1350 631/67/2329 631/67/71 Adenocarcinoma Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung Animals Anticancer properties Cancer cells Cancer metastasis Cancer research Cell Proliferation - drug effects Disease Progression Drug resistance Female Gene expression Growth factors Heterogeneity Histology Humanities and Social Sciences Humans letter Ligands Lung cancer Lung diseases Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical research Mice multidisciplinary Neoplasm Transplantation Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Perturbation Phenotypes Protein Processing, Post-Translational - drug effects Science Signal transduction Signaling Small Molecule Libraries - pharmacology Stem Cell Niche Stem cell transplantation Stem cells Subpopulations Survival Rate Tumors Wnt protein Wnt Proteins - biosynthesis Wnt Proteins - chemistry Wnt Proteins - metabolism Wnt Signaling Pathway
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