Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study
Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities...
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| Veröffentlicht in: | Environmental health perspectives 2017-05, Vol.125 (5), p.057003 |
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| description | Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown.
We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities and behavior.
We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry.
The median W-Mn was 0.20 mg/L (range 0.001–6.6) during pregnancy and 0.34mg/L ( |
| doi_str_mv | 10.1289/EHP631 |
| format | Article |
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We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities and behavior.
We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry.
The median W-Mn was 0.20 mg/L (range 0.001–6.6) during pregnancy and 0.34mg/L (<0.001–8.7) at 10 y. In multivariable-adjusted linear regression analyses, restricted to children with low arsenic (As) exposure, none of the W-Mn exposures was associated with the children’s cognitive abilities. Stratifying by gender (p for interaction in general <0.081) showed that prenatal W-Mn (3 mg/L) was positively associated with cognitive ability measures in girls but not in boys. W-Mn at all time points was associated with an increased risk of conduct problems, particularly in boys (range 24–43% per mg/L). At the same time, the prenatal W-Mn was associated with a decreased risk of emotional problems [odds ratio (OR)=0.39 (95% CI: 0.19, 0.82)] in boys. In girls, W-Mn was mainly associated with low prosocial scores [prenatal W-Mn: OR=1.48 (95% CI: 1.06, 1.88)].
Elevated prenatal W-Mn exposure was positively associated with cognitive function in girls, whereas boys appeared to be unaffected. Early life W-Mn exposure appeared to adversely affect children's behavior. https://doi.org/10.1289/EHP631.</description><identifier>ISSN: 0091-6765</identifier><identifier>ISSN: 1552-9924</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/EHP631</identifier><identifier>PMID: 28564632</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Age ; Arsenic ; Bangladesh - epidemiology ; Behavior ; Caregivers ; Child ; Children ; Children & youth ; Cognition & reasoning ; Cognition - drug effects ; Cognitive ability ; Cognitive disorders ; Cohort analysis ; Cohort Studies ; Conduct Disorder - chemically induced ; Data collection ; Drinking water ; Drinking Water - adverse effects ; Drinking Water - chemistry ; Education ; Exposure ; Families & family life ; Female ; Fetuses ; Girls ; Health aspects ; Health risk assessment ; Humans ; Inductively coupled plasma mass spectrometry ; Intelligence ; Intelligence Tests ; Male ; Manganese ; Manganese - adverse effects ; Manganese compounds ; Mass spectrometry ; Mass spectroscopy ; Medicin och hälsovetenskap ; Mothers ; Neurodevelopment ; Pregnancy ; Prenatal experience ; Prenatal Exposure Delayed Effects - chemically induced ; Prospective Studies ; Regression analysis ; Risk factors ; Sex Factors ; Studies ; Womens health</subject><ispartof>Environmental health perspectives, 2017-05, Vol.125 (5), p.057003</ispartof><rights>COPYRIGHT 2017 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences May 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-9b88c5f981e08929501b01afe8854267fc9aed53bda793e1a9d6ddf5b99f0993</citedby><cites>FETCH-LOGICAL-c550t-9b88c5f981e08929501b01afe8854267fc9aed53bda793e1a9d6ddf5b99f0993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726374/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726374/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,553,728,781,785,865,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28564632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:136877957$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahman, Syed Moshfiqur</creatorcontrib><creatorcontrib>Kippler, Maria</creatorcontrib><creatorcontrib>Tofail, Fahmida</creatorcontrib><creatorcontrib>Bölte, Sven</creatorcontrib><creatorcontrib>Hamadani, Jena Derakhshani</creatorcontrib><creatorcontrib>Vahter, Marie</creatorcontrib><title>Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown.
We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities and behavior.
We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry.
The median W-Mn was 0.20 mg/L (range 0.001–6.6) during pregnancy and 0.34mg/L (<0.001–8.7) at 10 y. In multivariable-adjusted linear regression analyses, restricted to children with low arsenic (As) exposure, none of the W-Mn exposures was associated with the children’s cognitive abilities. Stratifying by gender (p for interaction in general <0.081) showed that prenatal W-Mn (3 mg/L) was positively associated with cognitive ability measures in girls but not in boys. W-Mn at all time points was associated with an increased risk of conduct problems, particularly in boys (range 24–43% per mg/L). At the same time, the prenatal W-Mn was associated with a decreased risk of emotional problems [odds ratio (OR)=0.39 (95% CI: 0.19, 0.82)] in boys. In girls, W-Mn was mainly associated with low prosocial scores [prenatal W-Mn: OR=1.48 (95% CI: 1.06, 1.88)].
Elevated prenatal W-Mn exposure was positively associated with cognitive function in girls, whereas boys appeared to be unaffected. Early life W-Mn exposure appeared to adversely affect children's behavior. https://doi.org/10.1289/EHP631.</description><subject>Age</subject><subject>Arsenic</subject><subject>Bangladesh - epidemiology</subject><subject>Behavior</subject><subject>Caregivers</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cognition & reasoning</subject><subject>Cognition - drug effects</subject><subject>Cognitive ability</subject><subject>Cognitive disorders</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Conduct Disorder - chemically induced</subject><subject>Data collection</subject><subject>Drinking water</subject><subject>Drinking Water - adverse effects</subject><subject>Drinking Water - chemistry</subject><subject>Education</subject><subject>Exposure</subject><subject>Families & family life</subject><subject>Female</subject><subject>Fetuses</subject><subject>Girls</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Inductively coupled plasma mass spectrometry</subject><subject>Intelligence</subject><subject>Intelligence Tests</subject><subject>Male</subject><subject>Manganese</subject><subject>Manganese - adverse effects</subject><subject>Manganese compounds</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicin och hälsovetenskap</subject><subject>Mothers</subject><subject>Neurodevelopment</subject><subject>Pregnancy</subject><subject>Prenatal experience</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Sex Factors</subject><subject>Studies</subject><subject>Womens health</subject><issn>0091-6765</issn><issn>1552-9924</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>D8T</sourceid><recordid>eNp1kkFv1DAQhS0EokuBn4AsIXEL2HHs2ByQwlIoUhGVqIQ4WU4ySdym9tZ2FvXfY7rblh44zWj8vaeR5yH0kpK3tJTq3dHxqWD0EVpRzstCqbJ6jFaEKFqIWvAD9CzGc0IIlUI8RQel5KISrFwh_8240TiIgK3Dn4J1F9aN-KdJELBxPV770dlkt4Cb1s65g3gz_wiT2VqfoYQpwb_AhIj9gJsR3uMGnwYfN9DdCNd-8iHhH2npr5-jJ4OZI7zY10N09vnobH1cnHz_8nXdnBQd5yQVqpWy44OSFIhUpeKEtoSaAaTkVSnqoVMGes7a3tSKATWqF30_8FapgSjFDlGxs42_YbO0ehPspQnX2hur96OL3IGulKg4z7z6L78Jvr8X3QopE7KuFa-z9sNOm4FL6DtwKZj5ocWDF2cnPfqt5nUpWF1lg9d7g-CvFohJn_sluPw9uiSM1ZyWnGTqzY4azQx6AjOnKfp5Sda7qJtKSVmJuqL3YJdvEAMMd6tQov-GRe_CksFX_y5-h92mg_0BggO6ZA</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Rahman, 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in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study</title><author>Rahman, Syed Moshfiqur ; Kippler, Maria ; Tofail, Fahmida ; Bölte, Sven ; Hamadani, Jena Derakhshani ; Vahter, Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-9b88c5f981e08929501b01afe8854267fc9aed53bda793e1a9d6ddf5b99f0993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Arsenic</topic><topic>Bangladesh - epidemiology</topic><topic>Behavior</topic><topic>Caregivers</topic><topic>Child</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cognition & reasoning</topic><topic>Cognition - drug effects</topic><topic>Cognitive ability</topic><topic>Cognitive disorders</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Conduct Disorder - chemically induced</topic><topic>Data 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perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahman, Syed Moshfiqur</au><au>Kippler, Maria</au><au>Tofail, Fahmida</au><au>Bölte, Sven</au><au>Hamadani, Jena Derakhshani</au><au>Vahter, Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>125</volume><issue>5</issue><spage>057003</spage><pages>057003-</pages><issn>0091-6765</issn><issn>1552-9924</issn><eissn>1552-9924</eissn><abstract>Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown.
We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities and behavior.
We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry.
The median W-Mn was 0.20 mg/L (range 0.001–6.6) during pregnancy and 0.34mg/L (<0.001–8.7) at 10 y. In multivariable-adjusted linear regression analyses, restricted to children with low arsenic (As) exposure, none of the W-Mn exposures was associated with the children’s cognitive abilities. Stratifying by gender (p for interaction in general <0.081) showed that prenatal W-Mn (3 mg/L) was positively associated with cognitive ability measures in girls but not in boys. W-Mn at all time points was associated with an increased risk of conduct problems, particularly in boys (range 24–43% per mg/L). At the same time, the prenatal W-Mn was associated with a decreased risk of emotional problems [odds ratio (OR)=0.39 (95% CI: 0.19, 0.82)] in boys. In girls, W-Mn was mainly associated with low prosocial scores [prenatal W-Mn: OR=1.48 (95% CI: 1.06, 1.88)].
Elevated prenatal W-Mn exposure was positively associated with cognitive function in girls, whereas boys appeared to be unaffected. Early life W-Mn exposure appeared to adversely affect children's behavior. https://doi.org/10.1289/EHP631.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>28564632</pmid><doi>10.1289/EHP631</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2017-05, Vol.125 (5), p.057003 |
| issn | 0091-6765 1552-9924 1552-9924 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_496455 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; PubMed Central Open Access; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Age Arsenic Bangladesh - epidemiology Behavior Caregivers Child Children Children & youth Cognition & reasoning Cognition - drug effects Cognitive ability Cognitive disorders Cohort analysis Cohort Studies Conduct Disorder - chemically induced Data collection Drinking water Drinking Water - adverse effects Drinking Water - chemistry Education Exposure Families & family life Female Fetuses Girls Health aspects Health risk assessment Humans Inductively coupled plasma mass spectrometry Intelligence Intelligence Tests Male Manganese Manganese - adverse effects Manganese compounds Mass spectrometry Mass spectroscopy Medicin och hälsovetenskap Mothers Neurodevelopment Pregnancy Prenatal experience Prenatal Exposure Delayed Effects - chemically induced Prospective Studies Regression analysis Risk factors Sex Factors Studies Womens health |
| title | Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T16%3A21%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Manganese%20in%20Drinking%20Water%20and%20Cognitive%20Abilities%20and%20Behavior%20at%2010%20Years%20of%20Age:%20A%20Prospective%20Cohort%20Study&rft.jtitle=Environmental%20health%20perspectives&rft.au=Rahman,%20Syed%20Moshfiqur&rft.date=2017-05-01&rft.volume=125&rft.issue=5&rft.spage=057003&rft.pages=057003-&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/EHP631&rft_dat=%3Cgale_swepu%3EA498846741%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2033751250&rft_id=info:pmid/28564632&rft_galeid=A498846741&rfr_iscdi=true |