Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes

With very similar 3D structures, the widely expressed β-arrestin isoforms 1 and 2 play at times identical, distinct or even opposing roles in regulating various aspects of G protein-coupled receptors (GPCR) expression and signalling. Recent evidence recognizes the β-arrestin system as a key regulato...

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Veröffentlicht in:	Oncogene 2017-10, Vol.36 (41), p.5734-5744
Hauptverfasser:	Suleymanova, N, Crudden, C, Shibano, T, Worrall, C, Oprea, I, Tica, A, Calin, G A, Girnita, A, Girnita, L
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/109 13/31 13/89 13/95 631/67/1059/602 631/80/83 631/80/86/2368 82/80 82/83 Animals Apoptosis beta-Arrestins - genetics beta-Arrestins - metabolism Cell Biology Gene Expression Regulation, Neoplastic HEK293 Cells Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Mice Neoplasms - genetics Neoplasms - pathology Oncology Original original-article Phosphorylation Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Proteolysis Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Signal Transduction - genetics Tumor Suppressor Protein p53 - genetics
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