Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation

Although previous studies suggested that the expression of FMS-like tyrosine kinase 3 (Flt3) initiates downstream of mouse hematopoietic stem cells (HSCs), internal tandem duplications ( ITDs) have recently been suggested to intrinsically suppress HSCs. Herein, single-cell interrogation found mRNA e...

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Veröffentlicht in:	The Journal of experimental medicine 2017-07, Vol.214 (7), p.2005-2021
Hauptverfasser:	Mead, Adam J, Neo, Wen Hao, Barkas, Nikolaos, Matsuoka, Sahoko, Giustacchini, Alice, Facchini, Raffaella, Thongjuea, Supat, Jamieson, Lauren, Booth, Christopher A G, Fordham, Nicholas, Di Genua, Cristina, Atkinson, Deborah, Chowdhury, Onima, Repapi, Emmanouela, Gray, Nicki, Kharazi, Shabnam, Clark, Sally-Ann, Bouriez, Tiphaine, Woll, Petter, Suda, Toshio, Nerlov, Claus, Jacobsen, Sten Eirik W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone Marrow Transplantation Cell Proliferation - genetics Cells, Cultured Etanercept - pharmacology Flt3 protein fms-Like Tyrosine Kinase 3 - genetics Gene expression Gene Expression Profiling - methods Hematopoietic stem cells Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Interrogation Kinases Leukemia Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mesenchyme Mice Mice, Inbred C57BL Mice, Transgenic Mutation Myeloid leukemia Myeloproliferation Protein-tyrosine kinase Reservoirs Reverse Transcriptase Polymerase Chain Reaction Single-Cell Analysis - methods Stem Cell Niche - genetics Stem cell transplantation Stem cells Stromal cells Tandem Repeat Sequences - genetics Transplantation Tumor necrosis factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tyrosine
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