Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation

The beneficial health properties of the Mediterranean diet are well recognized. The principle source of fat in Mediterranean diet is extra-virgin olive oil (EVOO). Oleocanthal (OC) is a naturally occurring minor phenolic compound isolated from EVOO, which has shown a potent anti-inflammatory activit...

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Veröffentlicht in:	International journal of oncology 2017-08, Vol.51 (2), p.533-544
Hauptverfasser:	Cusimano, Antonella, Balasus, Daniele, Azzolina, Antonina, Augello, Giuseppa, Emma, Maria R, Di Sano, Caterina, Gramignoli, Roberto, Strom, Stephen C, Mccubrey, James A, Montalto, Giuseppe, Cervello, Melchiorre
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - administration & dosage Aldehydes - chemistry Apoptosis Apoptosis - drug effects Breast cancer Cancer therapies Carcinoma, Hepatocellular - diet therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - pathology Care and treatment Cell growth Cell Proliferation - drug effects Cellular signal transduction Colorectal cancer colorectal carcinoma Colorectal Neoplasms - diet therapy Colorectal Neoplasms - enzymology Colorectal Neoplasms - pathology Cyclooxygenase Inhibitors - administration & dosage Deoxyribonucleic acid Development and progression DNA DNA Damage - drug effects Enzymes extra-virgin olive oil Health aspects Hep G2 Cells Hepatocellular carcinoma Humans Inflammation Kinases Liver Liver cancer Liver Neoplasms - diet therapy Liver Neoplasms - enzymology Liver Neoplasms - pathology Medical prognosis Nonsteroidal anti-inflammatory drugs oleocanthal Olive Oil - administration & dosage Olive Oil - chemistry Phenols (Class of compounds) Phenols - administration & dosage Phenols - chemistry Phosphorylation Polyphenols Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Studies
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