Major Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children
Hair is a commonly used exposure biomarker for metals and other trace elements, but concern has been raised regarding its appropriateness for assessing the internal dose. The aim of the present study was to evaluate children's hair as biomarker of internal dose for toxic (As, Mn, Cd, Pb) and es...
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| Veröffentlicht in: | Environmental health perspectives 2017-06, Vol.125 (6), p.067021-067021 |
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| creator | Skröder, Helena Kippler, Maria Nermell, Barbro Tofail, Fahmida Levi, Michael Rahman, Syed Moshfiqur Raqib, Rubhana Vahter, Marie |
| description | Hair is a commonly used exposure biomarker for metals and other trace elements, but concern has been raised regarding its appropriateness for assessing the internal dose.
The aim of the present study was to evaluate children's hair as biomarker of internal dose for toxic (As, Mn, Cd, Pb) and essential elements (Mg, Ca, Fe, Co, Cu, Zn, Se, Mo).
In 207 children (9-10 years of age), originating from a population-based cohort in rural Bangladesh, we measured concentrations of the selected elements in hair ( closest to the scalp) using ICP-MS. We compared these with previously measured concentrations in erythrocytes, urine, and water. For a subset of children (n=19), we analyzed four consecutive 2 cm pieces of hair.
There were strong associations between hair As and the other biomarkers (erythrocytes:
=0.73, p |
| doi_str_mv | 10.1289/EHP1239 |
| format | Article |
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The aim of the present study was to evaluate children's hair as biomarker of internal dose for toxic (As, Mn, Cd, Pb) and essential elements (Mg, Ca, Fe, Co, Cu, Zn, Se, Mo).
In 207 children (9-10 years of age), originating from a population-based cohort in rural Bangladesh, we measured concentrations of the selected elements in hair ( closest to the scalp) using ICP-MS. We compared these with previously measured concentrations in erythrocytes, urine, and water. For a subset of children (n=19), we analyzed four consecutive 2 cm pieces of hair.
There were strong associations between hair As and the other biomarkers (erythrocytes:
=0.73, p<0.001; urine: rS=0.66, p<0.001); and water (
=0.60, p<0.001); and there were significant correlations between Se in hair and erythrocytes (overall
=0.38, p<0.001), and urine (
=0.29, p<0.001). Hair Co and Mo showed weak correlations with concentrations in erythrocytes. Hair Mn was not associated with Mn in erythrocytes, urine, or water, and the geometric mean concentration increased almost five times from the 2 cm closest to the head to the 7th–8th cm (p<0.001). Also Mg, Ca, Co, Cd, and Pb increased from the scalp outward (>50% higher in 7th–8th cm compared with 1st–2nd cm, p<0.001).
Hair was found to be a useful exposure biomarker of absorbed As and Se only. Of all measured elements, hair Mn seemed the least reflective of internal dose. https://doi.org/10.1289/EHP1239.]]></description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/EHP1239</identifier><identifier>PMID: 28669939</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Acids ; Age ; Analysis ; Arsenic ; Bangladesh ; Bioindicators ; Biological markers ; Biomarkers ; Biomarkers - analysis ; Cadmium ; Child ; Children ; Children & youth ; Cognitive ability ; Copper ; Drinking water ; Environmental Exposure - analysis ; Environmental Exposure - statistics & numerical data ; Environmental Pollutants - analysis ; Erythrocytes ; Exposure ; Female ; Hair ; Hair - chemistry ; Hair analysis ; Humans ; Iron ; Laboratories ; Lead ; Magnesium ; Male ; Manganese ; Metals ; Pregnancy ; Quality control ; Scalp ; Seafood ; Selenium ; Set theory ; Surveillance ; Trace elements ; Trace Elements - analysis ; Trace metals ; Urine ; Zinc</subject><ispartof>Environmental health perspectives, 2017-06, Vol.125 (6), p.067021-067021</ispartof><rights>COPYRIGHT 2017 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Jun 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c705t-aab24d39de98ca0919bad756a9a5df7cb0b7fb5165544025ac544f451d7b8f003</citedby><cites>FETCH-LOGICAL-c705t-aab24d39de98ca0919bad756a9a5df7cb0b7fb5165544025ac544f451d7b8f003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743543/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743543/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28669939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:140516313$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Skröder, Helena</creatorcontrib><creatorcontrib>Kippler, Maria</creatorcontrib><creatorcontrib>Nermell, Barbro</creatorcontrib><creatorcontrib>Tofail, Fahmida</creatorcontrib><creatorcontrib>Levi, Michael</creatorcontrib><creatorcontrib>Rahman, Syed Moshfiqur</creatorcontrib><creatorcontrib>Raqib, Rubhana</creatorcontrib><creatorcontrib>Vahter, Marie</creatorcontrib><title>Major Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description><![CDATA[Hair is a commonly used exposure biomarker for metals and other trace elements, but concern has been raised regarding its appropriateness for assessing the internal dose.
The aim of the present study was to evaluate children's hair as biomarker of internal dose for toxic (As, Mn, Cd, Pb) and essential elements (Mg, Ca, Fe, Co, Cu, Zn, Se, Mo).
In 207 children (9-10 years of age), originating from a population-based cohort in rural Bangladesh, we measured concentrations of the selected elements in hair ( closest to the scalp) using ICP-MS. We compared these with previously measured concentrations in erythrocytes, urine, and water. For a subset of children (n=19), we analyzed four consecutive 2 cm pieces of hair.
There were strong associations between hair As and the other biomarkers (erythrocytes:
=0.73, p<0.001; urine: rS=0.66, p<0.001); and water (
=0.60, p<0.001); and there were significant correlations between Se in hair and erythrocytes (overall
=0.38, p<0.001), and urine (
=0.29, p<0.001). Hair Co and Mo showed weak correlations with concentrations in erythrocytes. Hair Mn was not associated with Mn in erythrocytes, urine, or water, and the geometric mean concentration increased almost five times from the 2 cm closest to the head to the 7th–8th cm (p<0.001). Also Mg, Ca, Co, Cd, and Pb increased from the scalp outward (>50% higher in 7th–8th cm compared with 1st–2nd cm, p<0.001).
Hair was found to be a useful exposure biomarker of absorbed As and Se only. Of all measured elements, hair Mn seemed the least reflective of internal dose. https://doi.org/10.1289/EHP1239.]]></description><subject>Acids</subject><subject>Age</subject><subject>Analysis</subject><subject>Arsenic</subject><subject>Bangladesh</subject><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Cadmium</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cognitive ability</subject><subject>Copper</subject><subject>Drinking water</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Environmental Pollutants - analysis</subject><subject>Erythrocytes</subject><subject>Exposure</subject><subject>Female</subject><subject>Hair</subject><subject>Hair - chemistry</subject><subject>Hair analysis</subject><subject>Humans</subject><subject>Iron</subject><subject>Laboratories</subject><subject>Lead</subject><subject>Magnesium</subject><subject>Male</subject><subject>Manganese</subject><subject>Metals</subject><subject>Pregnancy</subject><subject>Quality control</subject><subject>Scalp</subject><subject>Seafood</subject><subject>Selenium</subject><subject>Set theory</subject><subject>Surveillance</subject><subject>Trace elements</subject><subject>Trace Elements - analysis</subject><subject>Trace 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Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children</title><author>Skröder, Helena ; Kippler, Maria ; Nermell, Barbro ; Tofail, Fahmida ; Levi, Michael ; Rahman, Syed Moshfiqur ; Raqib, Rubhana ; Vahter, Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c705t-aab24d39de98ca0919bad756a9a5df7cb0b7fb5165544025ac544f451d7b8f003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acids</topic><topic>Age</topic><topic>Analysis</topic><topic>Arsenic</topic><topic>Bangladesh</topic><topic>Bioindicators</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Cadmium</topic><topic>Child</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cognitive ability</topic><topic>Copper</topic><topic>Drinking water</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Exposure - statistics & numerical data</topic><topic>Environmental Pollutants - analysis</topic><topic>Erythrocytes</topic><topic>Exposure</topic><topic>Female</topic><topic>Hair</topic><topic>Hair - chemistry</topic><topic>Hair analysis</topic><topic>Humans</topic><topic>Iron</topic><topic>Laboratories</topic><topic>Lead</topic><topic>Magnesium</topic><topic>Male</topic><topic>Manganese</topic><topic>Metals</topic><topic>Pregnancy</topic><topic>Quality control</topic><topic>Scalp</topic><topic>Seafood</topic><topic>Selenium</topic><topic>Set theory</topic><topic>Surveillance</topic><topic>Trace elements</topic><topic>Trace Elements - analysis</topic><topic>Trace metals</topic><topic>Urine</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skröder, Helena</creatorcontrib><creatorcontrib>Kippler, Maria</creatorcontrib><creatorcontrib>Nermell, 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perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skröder, Helena</au><au>Kippler, Maria</au><au>Nermell, Barbro</au><au>Tofail, Fahmida</au><au>Levi, Michael</au><au>Rahman, Syed Moshfiqur</au><au>Raqib, Rubhana</au><au>Vahter, Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>125</volume><issue>6</issue><spage>067021</spage><epage>067021</epage><pages>067021-067021</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract><![CDATA[Hair is a commonly used exposure biomarker for metals and other trace elements, but concern has been raised regarding its appropriateness for assessing the internal dose.
The aim of the present study was to evaluate children's hair as biomarker of internal dose for toxic (As, Mn, Cd, Pb) and essential elements (Mg, Ca, Fe, Co, Cu, Zn, Se, Mo).
In 207 children (9-10 years of age), originating from a population-based cohort in rural Bangladesh, we measured concentrations of the selected elements in hair ( closest to the scalp) using ICP-MS. We compared these with previously measured concentrations in erythrocytes, urine, and water. For a subset of children (n=19), we analyzed four consecutive 2 cm pieces of hair.
There were strong associations between hair As and the other biomarkers (erythrocytes:
=0.73, p<0.001; urine: rS=0.66, p<0.001); and water (
=0.60, p<0.001); and there were significant correlations between Se in hair and erythrocytes (overall
=0.38, p<0.001), and urine (
=0.29, p<0.001). Hair Co and Mo showed weak correlations with concentrations in erythrocytes. Hair Mn was not associated with Mn in erythrocytes, urine, or water, and the geometric mean concentration increased almost five times from the 2 cm closest to the head to the 7th–8th cm (p<0.001). Also Mg, Ca, Co, Cd, and Pb increased from the scalp outward (>50% higher in 7th–8th cm compared with 1st–2nd cm, p<0.001).
Hair was found to be a useful exposure biomarker of absorbed As and Se only. Of all measured elements, hair Mn seemed the least reflective of internal dose. https://doi.org/10.1289/EHP1239.]]></abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>28669939</pmid><doi>10.1289/EHP1239</doi><tpages>67021(-67019)</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2017-06, Vol.125 (6), p.067021-067021 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_495696 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; SWEPUB Freely available online; PubMed Central Open Access; Jstor Complete Legacy; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acids Age Analysis Arsenic Bangladesh Bioindicators Biological markers Biomarkers Biomarkers - analysis Cadmium Child Children Children & youth Cognitive ability Copper Drinking water Environmental Exposure - analysis Environmental Exposure - statistics & numerical data Environmental Pollutants - analysis Erythrocytes Exposure Female Hair Hair - chemistry Hair analysis Humans Iron Laboratories Lead Magnesium Male Manganese Metals Pregnancy Quality control Scalp Seafood Selenium Set theory Surveillance Trace elements Trace Elements - analysis Trace metals Urine Zinc |
| title | Major Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T23%3A50%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Major%20Limitations%20in%20Using%20Element%20Concentrations%20in%20Hair%20as%20Biomarkers%20of%20Exposure%20to%20Toxic%20and%20Essential%20Trace%20Elements%20in%20Children&rft.jtitle=Environmental%20health%20perspectives&rft.au=Skr%C3%B6der,%20Helena&rft.date=2017-06-01&rft.volume=125&rft.issue=6&rft.spage=067021&rft.epage=067021&rft.pages=067021-067021&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/EHP1239&rft_dat=%3Cgale_swepu%3EA498846746%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2042688267&rft_id=info:pmid/28669939&rft_galeid=A498846746&rfr_iscdi=true |